FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415146009> ?p ?o ?g. }

• W2415146009 endingPage "1927" @default.
• W2415146009 startingPage "1923" @default.
• W2415146009 abstract "Abstract T-cell prolymphocytic leukemia (T-PLL), a rare form of mature T-cell leukemias, and ataxia telangiectasia clonal proliferation, a related condition occurring in patients suffering from ataxia telangiectasia, have been associated to translocations involving the 14q32.1 or Xq28 regions, where are located the TCL1 and MTCP1 putative oncogenes, respectively. The MTCP1 gene is involved in the t(X;14)(q28;q11) translocation associated with these T-cell proliferations. Alternative splicing generates type A and B transcripts that potentially encode two entirely distinct proteins; type A transcripts code for a small mitochondrial protein, p8MTCP1, and type B transcripts, containing an additional open reading frame, may code for 107 amino-acid protein, p13MTCP1. The recently cloned TCL1 gene, also involved in translocations and inversions associated with T-cell proliferations, codes for a 14-kD protein that displays significant homology with p13MTCP1. We have generated rabbit antisera against this putative p13MTCP1 protein and screened for expression of p13MTCP1 normal lymphoid tissues and 33 cases of immature and mature lymphoid T-cell proliferations using a sensitive Western blot assay. We also investigated the MTCP1 locus configuration by Southern blot analysis. The p13MTCP1 protein was detected in the three T-cell proliferations with MTCP1 rearrangements because of t(X;14) translocations, but neither in normal resting and activated lymphocytes nor in the other T- cell leukemias. Our data support the hypothesis that p13MTCP1 and p14TCL1 form a new protein family that plays a key role in the pathogenesis of T-PLL and related conditions." @default.
• W2415146009 created "2016-06-24" @default.
• W2415146009 creator A5028727344 @default.
• W2415146009 creator A5032557664 @default.
• W2415146009 creator A5044409234 @default.
• W2415146009 creator A5047731088 @default.
• W2415146009 creator A5057098654 @default.
• W2415146009 creator A5059789274 @default.
• W2415146009 creator A5062808434 @default.
• W2415146009 creator A5063006910 @default.
• W2415146009 creator A5066242750 @default.
• W2415146009 creator A5069446179 @default.
• W2415146009 creator A5075327873 @default.
• W2415146009 creator A5079545328 @default.
• W2415146009 creator A5088489013 @default.
• W2415146009 date "1996-03-01" @default.
• W2415146009 modified "2023-10-16" @default.
• W2415146009 title "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations" @default.
• W2415146009 cites W1502045208 @default.
• W2415146009 cites W1516624356 @default.
• W2415146009 cites W1554056275 @default.
• W2415146009 cites W1975085160 @default.
• W2415146009 cites W2059696397 @default.
• W2415146009 cites W2068003706 @default.
• W2415146009 cites W2074189042 @default.
• W2415146009 cites W2087631930 @default.
• W2415146009 cites W2123515007 @default.
• W2415146009 cites W2129856600 @default.
• W2415146009 cites W213585523 @default.
• W2415146009 cites W2144634347 @default.
• W2415146009 cites W2149266265 @default.
• W2415146009 cites W2369302706 @default.
• W2415146009 cites W2401927740 @default.
• W2415146009 cites W2408953747 @default.
• W2415146009 cites W2410638161 @default.
• W2415146009 cites W2411074991 @default.
• W2415146009 cites W2464033706 @default.
• W2415146009 cites W2469139252 @default.
• W2415146009 cites W81018373 @default.
• W2415146009 doi "https://doi.org/10.1182/blood.v87.5.1923.1923" @default.
• W2415146009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8634440" @default.
• W2415146009 hasPublicationYear "1996" @default.
• W2415146009 type Work @default.
• W2415146009 sameAs 2415146009 @default.
• W2415146009 citedByCount "83" @default.
• W2415146009 countsByYear W24151460092012 @default.
• W2415146009 countsByYear W24151460092013 @default.
• W2415146009 countsByYear W24151460092014 @default.
• W2415146009 countsByYear W24151460092015 @default.
• W2415146009 countsByYear W24151460092016 @default.
• W2415146009 countsByYear W24151460092017 @default.
• W2415146009 countsByYear W24151460092018 @default.
• W2415146009 countsByYear W24151460092019 @default.
• W2415146009 countsByYear W24151460092020 @default.
• W2415146009 countsByYear W24151460092021 @default.
• W2415146009 countsByYear W24151460092022 @default.
• W2415146009 crossrefType "journal-article" @default.
• W2415146009 hasAuthorship W2415146009A5028727344 @default.
• W2415146009 hasAuthorship W2415146009A5032557664 @default.
• W2415146009 hasAuthorship W2415146009A5044409234 @default.
• W2415146009 hasAuthorship W2415146009A5047731088 @default.
• W2415146009 hasAuthorship W2415146009A5057098654 @default.
• W2415146009 hasAuthorship W2415146009A5059789274 @default.
• W2415146009 hasAuthorship W2415146009A5062808434 @default.
• W2415146009 hasAuthorship W2415146009A5063006910 @default.
• W2415146009 hasAuthorship W2415146009A5066242750 @default.
• W2415146009 hasAuthorship W2415146009A5069446179 @default.
• W2415146009 hasAuthorship W2415146009A5075327873 @default.
• W2415146009 hasAuthorship W2415146009A5079545328 @default.
• W2415146009 hasAuthorship W2415146009A5088489013 @default.
• W2415146009 hasBestOaLocation W24151460091 @default.
• W2415146009 hasConcept C104317684 @default.
• W2415146009 hasConcept C138626823 @default.
• W2415146009 hasConcept C143425029 @default.
• W2415146009 hasConcept C153911025 @default.
• W2415146009 hasConcept C2776090121 @default.
• W2415146009 hasConcept C2778461978 @default.
• W2415146009 hasConcept C2779486608 @default.
• W2415146009 hasConcept C54355233 @default.
• W2415146009 hasConcept C552990157 @default.
• W2415146009 hasConcept C86803240 @default.
• W2415146009 hasConcept C8891405 @default.
• W2415146009 hasConceptScore W2415146009C104317684 @default.
• W2415146009 hasConceptScore W2415146009C138626823 @default.
• W2415146009 hasConceptScore W2415146009C143425029 @default.
• W2415146009 hasConceptScore W2415146009C153911025 @default.
• W2415146009 hasConceptScore W2415146009C2776090121 @default.
• W2415146009 hasConceptScore W2415146009C2778461978 @default.
• W2415146009 hasConceptScore W2415146009C2779486608 @default.
• W2415146009 hasConceptScore W2415146009C54355233 @default.
• W2415146009 hasConceptScore W2415146009C552990157 @default.
• W2415146009 hasConceptScore W2415146009C86803240 @default.
• W2415146009 hasConceptScore W2415146009C8891405 @default.
• W2415146009 hasIssue "5" @default.
• W2415146009 hasLocation W24151460091 @default.
• W2415146009 hasOpenAccess W2415146009 @default.
• W2415146009 hasPrimaryLocation W24151460091 @default.
• W2415146009 hasRelatedWork W1828691184 @default.

• next