Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415150832> ?p ?o ?g. }
- W2415150832 endingPage "44533" @default.
- W2415150832 startingPage "44522" @default.
- W2415150832 abstract "MicroRNAs (miRNAs) have been proved to play crucial roles in tumorigenesis. TGFβ signal pathway abnormality is found in various cancers and correlates with tumor proliferation and metastasis. However, the mechanisms underlying the dys-regulation of TGFβR2 expression in GC have not been investigated yet. In this study, we found that the TGFβR2 protein was clearly repressed in tumor tissues, while miR-130 expression level was dramatically increased in GC tissues. Firefly luciferase activity assay revealed that miR-130 could directly bind to 3'UTR of TGFβR2 mRNA. Meanwhile, miR-130 mimics lead to the decreased TGFβR2 protein levels, while miR-130 inhibitors enhanced TGFβR2 expression in SGC7901 cells. Subsequent functional experiments showed that overexpressed miR-130 could promote proliferation and migration of SGC7901 cells. And siRNA-mediated TGFβR2 down-regulation could simulate the effects of miR-130 mimics on phenotypes of SGC7901 cells. Furthermore, there existed intense relationship between the expression level of miR-130 and epithelial-mesenchymal markers. Our results demonstrated that miR-130 was an oncogene by directly targeting TGFβR2 in GC." @default.
- W2415150832 created "2016-06-24" @default.
- W2415150832 creator A5009956939 @default.
- W2415150832 creator A5021019207 @default.
- W2415150832 creator A5022356244 @default.
- W2415150832 creator A5027367192 @default.
- W2415150832 creator A5027639997 @default.
- W2415150832 creator A5037658093 @default.
- W2415150832 creator A5040697321 @default.
- W2415150832 creator A5043225123 @default.
- W2415150832 creator A5046626172 @default.
- W2415150832 creator A5063650098 @default.
- W2415150832 creator A5067865085 @default.
- W2415150832 date "2016-06-10" @default.
- W2415150832 modified "2023-10-15" @default.
- W2415150832 title "Onco-miR-130 promotes cell proliferation and migration by targeting TGFβR2 in gastric cancer" @default.
- W2415150832 cites W144423133 @default.
- W2415150832 cites W1771120914 @default.
- W2415150832 cites W1809627334 @default.
- W2415150832 cites W1876502538 @default.
- W2415150832 cites W1920303762 @default.
- W2415150832 cites W1936655728 @default.
- W2415150832 cites W1999508205 @default.
- W2415150832 cites W2011785195 @default.
- W2415150832 cites W2017128657 @default.
- W2415150832 cites W2017570593 @default.
- W2415150832 cites W2019876490 @default.
- W2415150832 cites W2024301198 @default.
- W2415150832 cites W2031350461 @default.
- W2415150832 cites W2064292948 @default.
- W2415150832 cites W2076573596 @default.
- W2415150832 cites W2083365530 @default.
- W2415150832 cites W2084414513 @default.
- W2415150832 cites W2097655831 @default.
- W2415150832 cites W2098726705 @default.
- W2415150832 cites W2100444307 @default.
- W2415150832 cites W2108775841 @default.
- W2415150832 cites W2114993186 @default.
- W2415150832 cites W2115590702 @default.
- W2415150832 cites W2119721768 @default.
- W2415150832 cites W2124767573 @default.
- W2415150832 cites W2130229338 @default.
- W2415150832 cites W2141860100 @default.
- W2415150832 cites W2141886767 @default.
- W2415150832 cites W2142806708 @default.
- W2415150832 cites W2144162491 @default.
- W2415150832 cites W2157348113 @default.
- W2415150832 cites W2164733896 @default.
- W2415150832 cites W2177452586 @default.
- W2415150832 cites W2198219779 @default.
- W2415150832 cites W2404457973 @default.
- W2415150832 cites W4211113621 @default.
- W2415150832 doi "https://doi.org/10.18632/oncotarget.9936" @default.
- W2415150832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5190115" @default.
- W2415150832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27304191" @default.
- W2415150832 hasPublicationYear "2016" @default.
- W2415150832 type Work @default.
- W2415150832 sameAs 2415150832 @default.
- W2415150832 citedByCount "52" @default.
- W2415150832 countsByYear W24151508322016 @default.
- W2415150832 countsByYear W24151508322017 @default.
- W2415150832 countsByYear W24151508322018 @default.
- W2415150832 countsByYear W24151508322019 @default.
- W2415150832 countsByYear W24151508322020 @default.
- W2415150832 countsByYear W24151508322021 @default.
- W2415150832 countsByYear W24151508322022 @default.
- W2415150832 countsByYear W24151508322023 @default.
- W2415150832 crossrefType "journal-article" @default.
- W2415150832 hasAuthorship W2415150832A5009956939 @default.
- W2415150832 hasAuthorship W2415150832A5021019207 @default.
- W2415150832 hasAuthorship W2415150832A5022356244 @default.
- W2415150832 hasAuthorship W2415150832A5027367192 @default.
- W2415150832 hasAuthorship W2415150832A5027639997 @default.
- W2415150832 hasAuthorship W2415150832A5037658093 @default.
- W2415150832 hasAuthorship W2415150832A5040697321 @default.
- W2415150832 hasAuthorship W2415150832A5043225123 @default.
- W2415150832 hasAuthorship W2415150832A5046626172 @default.
- W2415150832 hasAuthorship W2415150832A5063650098 @default.
- W2415150832 hasAuthorship W2415150832A5067865085 @default.
- W2415150832 hasBestOaLocation W24151508321 @default.
- W2415150832 hasConcept C104317684 @default.
- W2415150832 hasConcept C111335760 @default.
- W2415150832 hasConcept C118131993 @default.
- W2415150832 hasConcept C121608353 @default.
- W2415150832 hasConcept C145059251 @default.
- W2415150832 hasConcept C173396325 @default.
- W2415150832 hasConcept C2779013556 @default.
- W2415150832 hasConcept C2781018059 @default.
- W2415150832 hasConcept C29537977 @default.
- W2415150832 hasConcept C502942594 @default.
- W2415150832 hasConcept C54009773 @default.
- W2415150832 hasConcept C54355233 @default.
- W2415150832 hasConcept C555283112 @default.
- W2415150832 hasConcept C62112901 @default.
- W2415150832 hasConcept C81885089 @default.
- W2415150832 hasConcept C86803240 @default.
- W2415150832 hasConcept C95444343 @default.
- W2415150832 hasConceptScore W2415150832C104317684 @default.