Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415192268> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2415192268 endingPage "8" @default.
- W2415192268 startingPage "563" @default.
- W2415192268 abstract "Thrombocytopenia is a common problem in cardiovascular patients, and heparin-induced thrombocytopenia (HIT) is therefore frequently suspected. Unfractionated heparin during cardiopulmonary bypass is particularly immunogenic as 25% to 50% post-cardiac surgery patients develop heparin-dependent antibodies but only 1 to 3% will develop HIT. These antibodies recognize a 'self protein', platelet factor 4 (PF4), bound to heparin. Antibodies associated with a high risk of HIT are mainly IgG1 which strongly activate platelets and coagulation, thereby causing thrombocytopenia and thrombosis. A biphasic evolution of platelet count with a secondary decrease after a previous increase following CPB or non-recovery of thrombocytopenia within 6 days post-operatively always requires screening for HIT antibodies. Both functional (platelet activation tests) and immunologic assays (antigen assays) are necessary in every patient to establish the diagnosis of HIT. When the clinical probability of HIT is high, the first requirement is to discontinue heparin, without waiting for results of laboratory investigations. An alternative anticoagulant such as danaparoid sodium (Orgaran) or lepirudin (Refludan) must then be administered since heparin withdrawal alone is insufficient to control the prothrombotic state associated with HIT. The risk of HIT will probably soon decrease due to the wider use of fondaparinux, which does not interact in vitro with PF4, but it could remain significant in patients undergoing cardiac surgery with CPB." @default.
- W2415192268 created "2016-06-24" @default.
- W2415192268 creator A5004622716 @default.
- W2415192268 creator A5013650708 @default.
- W2415192268 creator A5018171524 @default.
- W2415192268 creator A5064229866 @default.
- W2415192268 date "2007-09-26" @default.
- W2415192268 modified "2023-09-26" @default.
- W2415192268 title "Heparin-induced thrombocytopenia: a frequent complication after cardiac surgery." @default.
- W2415192268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17893639" @default.
- W2415192268 hasPublicationYear "2007" @default.
- W2415192268 type Work @default.
- W2415192268 sameAs 2415192268 @default.
- W2415192268 citedByCount "7" @default.
- W2415192268 countsByYear W24151922682012 @default.
- W2415192268 countsByYear W24151922682014 @default.
- W2415192268 countsByYear W24151922682022 @default.
- W2415192268 crossrefType "journal-article" @default.
- W2415192268 hasAuthorship W2415192268A5004622716 @default.
- W2415192268 hasAuthorship W2415192268A5013650708 @default.
- W2415192268 hasAuthorship W2415192268A5018171524 @default.
- W2415192268 hasAuthorship W2415192268A5064229866 @default.
- W2415192268 hasConcept C141071460 @default.
- W2415192268 hasConcept C159973064 @default.
- W2415192268 hasConcept C203014093 @default.
- W2415192268 hasConcept C2776472838 @default.
- W2415192268 hasConcept C2776877702 @default.
- W2415192268 hasConcept C2777292125 @default.
- W2415192268 hasConcept C2777557582 @default.
- W2415192268 hasConcept C2778205648 @default.
- W2415192268 hasConcept C2778789114 @default.
- W2415192268 hasConcept C2778881276 @default.
- W2415192268 hasConcept C2779026020 @default.
- W2415192268 hasConcept C2779612170 @default.
- W2415192268 hasConcept C2780205058 @default.
- W2415192268 hasConcept C2780868729 @default.
- W2415192268 hasConcept C2991741193 @default.
- W2415192268 hasConcept C3018697912 @default.
- W2415192268 hasConcept C42219234 @default.
- W2415192268 hasConcept C71924100 @default.
- W2415192268 hasConcept C81182388 @default.
- W2415192268 hasConcept C89560881 @default.
- W2415192268 hasConceptScore W2415192268C141071460 @default.
- W2415192268 hasConceptScore W2415192268C159973064 @default.
- W2415192268 hasConceptScore W2415192268C203014093 @default.
- W2415192268 hasConceptScore W2415192268C2776472838 @default.
- W2415192268 hasConceptScore W2415192268C2776877702 @default.
- W2415192268 hasConceptScore W2415192268C2777292125 @default.
- W2415192268 hasConceptScore W2415192268C2777557582 @default.
- W2415192268 hasConceptScore W2415192268C2778205648 @default.
- W2415192268 hasConceptScore W2415192268C2778789114 @default.
- W2415192268 hasConceptScore W2415192268C2778881276 @default.
- W2415192268 hasConceptScore W2415192268C2779026020 @default.
- W2415192268 hasConceptScore W2415192268C2779612170 @default.
- W2415192268 hasConceptScore W2415192268C2780205058 @default.
- W2415192268 hasConceptScore W2415192268C2780868729 @default.
- W2415192268 hasConceptScore W2415192268C2991741193 @default.
- W2415192268 hasConceptScore W2415192268C3018697912 @default.
- W2415192268 hasConceptScore W2415192268C42219234 @default.
- W2415192268 hasConceptScore W2415192268C71924100 @default.
- W2415192268 hasConceptScore W2415192268C81182388 @default.
- W2415192268 hasConceptScore W2415192268C89560881 @default.
- W2415192268 hasIssue "6-7" @default.
- W2415192268 hasLocation W24151922681 @default.
- W2415192268 hasOpenAccess W2415192268 @default.
- W2415192268 hasPrimaryLocation W24151922681 @default.
- W2415192268 hasRelatedWork W1992884184 @default.
- W2415192268 hasRelatedWork W2001080845 @default.
- W2415192268 hasRelatedWork W2007877932 @default.
- W2415192268 hasRelatedWork W2009061410 @default.
- W2415192268 hasRelatedWork W2011466864 @default.
- W2415192268 hasRelatedWork W2058043635 @default.
- W2415192268 hasRelatedWork W2067502983 @default.
- W2415192268 hasRelatedWork W2068579130 @default.
- W2415192268 hasRelatedWork W2078762975 @default.
- W2415192268 hasRelatedWork W2115526409 @default.
- W2415192268 hasRelatedWork W2117578213 @default.
- W2415192268 hasRelatedWork W2118531224 @default.
- W2415192268 hasRelatedWork W2120230173 @default.
- W2415192268 hasRelatedWork W2123374799 @default.
- W2415192268 hasRelatedWork W2125322011 @default.
- W2415192268 hasRelatedWork W2153904317 @default.
- W2415192268 hasRelatedWork W2344421872 @default.
- W2415192268 hasRelatedWork W2470137488 @default.
- W2415192268 hasRelatedWork W2511981222 @default.
- W2415192268 hasRelatedWork W74136874 @default.
- W2415192268 hasVolume "100" @default.
- W2415192268 isParatext "false" @default.
- W2415192268 isRetracted "false" @default.
- W2415192268 magId "2415192268" @default.
- W2415192268 workType "article" @default.