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• W2415193531 abstract "Randomized double-blind placebo controlled studies have consistently demonstrated the safety and effectiveness of selective alpha 1 blockers for the treatment of clinical BPH. Selective alpha 1 blockers relieve the symptoms of prostatism and decrease bladder outlet obstruction. The advantages of this class of drugs for the medical treatment of BPH include the extremely rapid onset of action, statistically and clinically significant effects on relevant outcome measures, adverse experiences that are generally infrequent, mild, and reversible, serum PSA levels are not affected, and hypertension is also effectively treated. The long-term effectiveness of selective alpha 1 blockers has recently been reported. Prostate smooth muscle tension is mediated by the alpha 1a (previously defined as alpha 1c) AR. The pharmaceutical industry is aggressively pursuing development of alpha 1a prostate selective AR antagonists." @default.
• W2415193531 created "2016-06-24" @default.
• W2415193531 creator A5011556876 @default.
• W2415193531 date "1995-05-01" @default.
• W2415193531 modified "2023-10-16" @default.
• W2415193531 title "ALPHA BLOCKADE FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA" @default.
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• W2415193531 doi "https://doi.org/10.1016/s0094-0143(21)00673-x" @default.
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