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- W2415209314 abstract "The mammary tumour virus (MTV) contents of mammary tumours (MT's) of various mouse strains were investigated by means of the indirect immunofluorescence technique and the electron microscopy. Only in acinus-forming, well differentiated MT's MTV-B particles could be observed in high quantity. The release of B particles seems to be correlated with the degree of structural ripeness of the tumor tissue. As to intracytoplasmic A particles such a strong relationship could not be found out. Many A particles were seen in mature adenocarcinomas as well as in acinus-free tumours. Some mammary carcinomas of an extreme low degree of histomorphological differentiation were free of any detectable virus production. The indirect immunofluorescence test was confirmed as a sensitive method for the detection of MTV antigens in MT slices. Using polyvalent anti-MTV sera, obtained after immunization of rabbits with ether-disrupted B particles from tumour tissue or milk, the test system allowed the distinction of A and B particle antigens. Accumulations of B particles were seen as an intercellular fluorescence reaction while clusters of A particles were represented by a granular paranuclear reaction within the tumor cells." @default.
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- W2415209314 date "1974-01-01" @default.
- W2415209314 modified "2023-09-23" @default.
- W2415209314 title "[Correlation between the production of mature mammary tumour virus particles and the histomorphological differentiation of murine mammary tumours]." @default.
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