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- W2415227941 abstract "<h3>Introduction</h3> Whilst alpha feto-protein is secreted by some hepatocellular carcinoma, it is not recommended for diagnosis in current guidelines. It is well recognised as a marker of prognosis in hepatocellular carcinoma and therefore we aimed to determine an appropriate cut-off value that would provide optimal prognostic information for this cancer. <h3>Method</h3> Consecutive patients (n = 432) with valid alpha feto-protein measurements diagnosed with hepatocellular carcinoma during 2005 to 2014 in the Liverpool region, UK were included. The area under the receiver operating characteristic curve of alpha feto-protein by status of patients was used to determine the optimal cut-off. This value was then used to assess overall survival of the study population by type of treatment. The predictive performance of the new cut-off was assessed by its performance in the Hepatoma arterial-embolisation prognostic score of patients treated by trans-arterial chemoembolisation. <h3>Results</h3> Serum alpha feto-protein value, ≥43 ng/mL predicted prognosis (sensitivity 48% / specificity 78%) better than ≥400 ng/mL (sensitivity 28%/specificity 89%). The median survival was 28 months (95% CI: 21–33) in patients with AFP <43 ng/mL and 7 months (95% CI: 5–8) for those whose alpha feto-protein was ≥43 ng/mL. Also, accurate prediction of survival for hepatocellular carcinoma patients receiving loco-regional therapy (34 months vs. 14 months, p < 0.0001) and curative therapy (43 months vs. 15 months, p = 0.001) was obtained. <h3>Conclusion</h3> An alpha feto-protein of ≥43 was defined as the optimal cut-off to aid prognostic predictions. These results require external validation before recommendation for decision making in clinical practice. <h3>Disclosure of interest</h3> None Declared." @default.
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- W2415227941 date "2015-06-01" @default.
- W2415227941 modified "2023-10-16" @default.
- W2415227941 title "PTH-111 Alpha-fetoprotein (afp) in hepatocellular carcinoma (hcc): determination of optimum cut-off value for prognosis" @default.
- W2415227941 doi "https://doi.org/10.1136/gutjnl-2015-309861.999" @default.
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