Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415294704> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2415294704 endingPage "76" @default.
- W2415294704 startingPage "168" @default.
- W2415294704 abstract "Both leukotrienes and their receptor antagonists possess substantial pharmacologic activity in in vitro systems, but their duration of action in vivo is extremely short. The exact mechanism of rapid inactivation of these lipids is unknown, but is likely due to metabolism. Therefore, the metabolic fate of a model antagonist 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid (SK&F 102,081) was elucidated in anesthetized guinea pigs. Following iv administration of [14C]SK&F 102,081 (5 mg/kg), 85% of injected radioactivity was excreted in bile in 1 hr. Approximately 6% of the radioactivity in bile was associated with parent. At least 14 metabolites were present in bile, 2 of which accounted for almost 60% of the excreted radioactivity. Identification of biliary metabolites revealed that metabolism occurred by two major routes, omega-oxidation with subsequent beta-oxidation and acyl glucuronidation at approximately a 4:1 ratio. Since current structure-activity relationships suggest that omega-oxidation results in the loss of pharmacologic activity of SK&F 102,081, the rapid loss in pharmacologic activity observed in vivo may be due to rapid metabolism." @default.
- W2415294704 created "2016-06-24" @default.
- W2415294704 creator A5011887743 @default.
- W2415294704 creator A5014481950 @default.
- W2415294704 creator A5015904916 @default.
- W2415294704 creator A5018150065 @default.
- W2415294704 creator A5027884661 @default.
- W2415294704 creator A5065738888 @default.
- W2415294704 creator A5090309105 @default.
- W2415294704 date "1987-03-01" @default.
- W2415294704 modified "2023-09-23" @default.
- W2415294704 title "In vivo metabolism of the leukotriene receptor antagonist, 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid (SK&F 102,081) in the guinea pig." @default.
- W2415294704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2882973" @default.
- W2415294704 hasPublicationYear "1987" @default.
- W2415294704 type Work @default.
- W2415294704 sameAs 2415294704 @default.
- W2415294704 citedByCount "1" @default.
- W2415294704 crossrefType "journal-article" @default.
- W2415294704 hasAuthorship W2415294704A5011887743 @default.
- W2415294704 hasAuthorship W2415294704A5014481950 @default.
- W2415294704 hasAuthorship W2415294704A5015904916 @default.
- W2415294704 hasAuthorship W2415294704A5018150065 @default.
- W2415294704 hasAuthorship W2415294704A5027884661 @default.
- W2415294704 hasAuthorship W2415294704A5065738888 @default.
- W2415294704 hasAuthorship W2415294704A5090309105 @default.
- W2415294704 hasConcept C126322002 @default.
- W2415294704 hasConcept C134018914 @default.
- W2415294704 hasConcept C150903083 @default.
- W2415294704 hasConcept C170493617 @default.
- W2415294704 hasConcept C185592680 @default.
- W2415294704 hasConcept C202751555 @default.
- W2415294704 hasConcept C207001950 @default.
- W2415294704 hasConcept C2776042228 @default.
- W2415294704 hasConcept C2776452501 @default.
- W2415294704 hasConcept C2776885963 @default.
- W2415294704 hasConcept C2778815084 @default.
- W2415294704 hasConcept C2779907587 @default.
- W2415294704 hasConcept C55493867 @default.
- W2415294704 hasConcept C62231903 @default.
- W2415294704 hasConcept C71924100 @default.
- W2415294704 hasConcept C86803240 @default.
- W2415294704 hasConcept C87644729 @default.
- W2415294704 hasConcept C98274493 @default.
- W2415294704 hasConceptScore W2415294704C126322002 @default.
- W2415294704 hasConceptScore W2415294704C134018914 @default.
- W2415294704 hasConceptScore W2415294704C150903083 @default.
- W2415294704 hasConceptScore W2415294704C170493617 @default.
- W2415294704 hasConceptScore W2415294704C185592680 @default.
- W2415294704 hasConceptScore W2415294704C202751555 @default.
- W2415294704 hasConceptScore W2415294704C207001950 @default.
- W2415294704 hasConceptScore W2415294704C2776042228 @default.
- W2415294704 hasConceptScore W2415294704C2776452501 @default.
- W2415294704 hasConceptScore W2415294704C2776885963 @default.
- W2415294704 hasConceptScore W2415294704C2778815084 @default.
- W2415294704 hasConceptScore W2415294704C2779907587 @default.
- W2415294704 hasConceptScore W2415294704C55493867 @default.
- W2415294704 hasConceptScore W2415294704C62231903 @default.
- W2415294704 hasConceptScore W2415294704C71924100 @default.
- W2415294704 hasConceptScore W2415294704C86803240 @default.
- W2415294704 hasConceptScore W2415294704C87644729 @default.
- W2415294704 hasConceptScore W2415294704C98274493 @default.
- W2415294704 hasIssue "2" @default.
- W2415294704 hasLocation W24152947041 @default.
- W2415294704 hasOpenAccess W2415294704 @default.
- W2415294704 hasPrimaryLocation W24152947041 @default.
- W2415294704 hasRelatedWork W2005558530 @default.
- W2415294704 hasRelatedWork W2013570490 @default.
- W2415294704 hasRelatedWork W2015681684 @default.
- W2415294704 hasRelatedWork W2024049424 @default.
- W2415294704 hasRelatedWork W2034583712 @default.
- W2415294704 hasRelatedWork W2061829983 @default.
- W2415294704 hasRelatedWork W2063619316 @default.
- W2415294704 hasRelatedWork W2169225653 @default.
- W2415294704 hasRelatedWork W2415294704 @default.
- W2415294704 hasRelatedWork W2890097984 @default.
- W2415294704 hasVolume "15" @default.
- W2415294704 isParatext "false" @default.
- W2415294704 isRetracted "false" @default.
- W2415294704 magId "2415294704" @default.
- W2415294704 workType "article" @default.