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• W2415314774 abstract "No AccessJournal of Urology1 Aug 1994Differential Release of Prostaglandins and Leukotrienes by Sensitized Guinea Pig Urinary Bladder Layers Upon Antigen Challenge Ricardo Saban, Brad J. Undem, Ingegerd M. Keith, Marcia R. Saban, Mark W. Tengowski, Frank M. Graziano, and Dale E. Bjorling Ricardo SabanRicardo Saban More articles by this author , Brad J. UndemBrad J. Undem More articles by this author , Ingegerd M. KeithIngegerd M. Keith More articles by this author , Marcia R. SabanMarcia R. Saban More articles by this author , Mark W. TengowskiMark W. Tengowski More articles by this author , Frank M. GrazianoFrank M. Graziano More articles by this author , and Dale E. BjorlingDale E. Bjorling More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)32790-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The relative contributions of mucosal/submucosal and detrusor layers to the release of inflammatory mediators were investigated in isolated, ovalbumin (OVA) sensitized guinea pig urinary bladders. Ovalbumin challenge of sensitized mucosa induced release of prostaglandins (PG): PGE2, PGD2 and PGF2α, in that order of magnitude. The total release of PGs was significantly higher from the mucosa/submucosa than from the detrusor/serosa. Under the same conditions, net release of leukotriene (LT) was observed predominantly from the detrusor. The total amount of histamine released from the mucosa was greater than that from the muscle layer. These results indicate differential production and release of inflammatory mediators from the mucosal/submucosal and detrusor smooth muscle layers. These results may have serious implications in disorders, such as interstitial cystitis, involving bladder mucosal damage. The cytoprotective effect of PGE2 is likely to be lost when the mucosa is damaged, and LT release from deeper layers may contribute significantly to symptoms of bladder inflammation. © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byTarcan T, Özdemir İ and Önol F (2018) The Role of α1-Adrenoceptor and Arachidonate Pathways in Increased Tone of Demucosalized Bladder TissueJournal of Urology, VOL. 181, NO. 6, (2780-2789), Online publication date: 1-Jun-2009.Saban R (2018) Dual Contribution of Cyclooxygenase and Lipoxygenase Pathways in Bladder ContractilityJournal of Urology, VOL. 181, NO. 6, (2416-2417), Online publication date: 1-Jun-2009.BOUCHELOUCHE K, ALVAREZ S, ANDERSEN L, NORDLING J, HORN T and BOUCHELOUCHE P (2018) Monocyte Chemoattractant Protein-1 Production by Human Detrusor Smooth Muscle CellsJournal of Urology, VOL. 171, NO. 1, (462-466), Online publication date: 1-Jan-2004.WANG X, SABAN R, KAYSEN J, SABAN M, ALLEN P, BENES E and HAMMOND T (2018) NUCLEAR FACTOR KAPPA B MEDIATES LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION IN THE URINARY BLADDERJournal of Urology, VOL. 163, NO. 3, (993-998), Online publication date: 1-Mar-2000.Lee J, Levin R, Krasnopolsky L, Wein A and Longhurst P (2018) Effects of the Peptide Leukotriene Receptor Antagonist ICI 198,615 on the In Vivo and In Vitro Changes in Guinea Pig Bladder Function Which Occur After Sensitization with OvalbuminJournal of Urology, VOL. 154, NO. 3, (1217-1221), Online publication date: 1-Sep-1995. Volume 152Issue 2 Part 1August 1994Page: 544-549 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.KeywordscystitisprostaglandinshistamineeicosanoidsleukotrienesMetricsAuthor Information Ricardo Saban More articles by this author Brad J. Undem More articles by this author Ingegerd M. Keith More articles by this author Marcia R. Saban More articles by this author Mark W. Tengowski More articles by this author Frank M. Graziano More articles by this author Dale E. Bjorling More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2415314774 title "Differential Release of Prostaglandins and Leukotrienes by Sensitized Guinea Pig Urinary Bladder Layers Upon Antigen Challenge" @default.
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