FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415325853> ?p ?o ?g. }

• W2415325853 endingPage "112" @default.
• W2415325853 startingPage "97" @default.
• W2415325853 abstract "A new clinical classification for Hodgkin's disease is proposed by the Committee for the Study of Malignant Lymphomas of the National Cancer Institute of Milan in cooperation with the Institute of Radiology of the University of Milan. The method of treatment of Hodgkin's disease adopted in these Institutes is also outlined. The histologic classification includes paragranuloma, nodular sclerosis, granuloma and sarcoma. Stage I: disease limited to a single peripheric lymphatic region. Within this stage two groups can be recognized: a) involvement of one single lymph node or few nodes limited to a small area of the region (unifocal lesions); b) involvement of many nodes spread throughout the region (uniregional lesions). Stage II: disease limited to two contiguous lymphatic regions, or to few deep nodes (mediastinal, retroperitoneal). Stage III: disease limited to two non contiguous peripheric lymphatic regions, or to many peripheric and/or deep (mediastinal, retroperitoneal) regions, provided the involvement is either above or below the diaphragm. Stage IV: generalized disease with involvement of lymph nodes above and below the diaphragm, or involvement of one or more lymphatic regions with concomitant involvement of visceral organs, bones, marrow, nervous system and skin. Systemic symptoms and signs, fatigue, fever, night sweats, loss of weight, itching, anemia, lymphocytopenia, high erythrosedimentation rate) must be recorded in each case to evaluate prognosis and proper treatment, bu are not considered in this classification for lymph node staging. Primary visceral, bone, nervous and cutaneous involvement is exceptional; therefore staging for such lesions is not considered in this classification. In all stages endolymphatic radiotherapy with Lipiodol F 131 I is indicated (10 ml in each foot with 2.5 mc/ml, corresponding to a tumor-dose of 15 - 20,000 rads). This is considered as a radical as well as a prophylactic treatment for those lymph nodes adequally filled with the contrast material; in case of non filling or incomplete filling of part of the lymph node chain, treatment will be completed with external radiation therapy. Stage I and II are treated with radical and prophylactic radiotherapy. If systemic symptoms and signs are still present after radiotheraphy, a course with anticancer drugs will be administered. Radiation therapy is given with high voltage or Co 60 units. In radical treatments tumor doses of at least 3,000 r within 3–4 weeks are administered to all involved lymphatic regions. Prophylactic radiotherapy is indicated for regions clinically free of disease but contiguous to the involved areas, with tumor doses not less than 3,000 r in 3–4 weeks. In stage II radical radiotherapy follows a course with chemotherapy. In stage IV chemotherapy is the treatment of choice; palliative radiotherapy is given to any bulk of tumors, wherever the location, when specific symptoms can be attributed to the masses. The anticancer drug of choice is methyl-bis-(β-chloro-ethyl)-amine HCl(HN2) 0.4 mg/kg i.v., for those patients who did not receive any previous course of chemotherapy. Otherwise, as well as during the course of the disease, other polyfunctional alkylating agents, vinblastine (alone or in combination with chlorambucil), methylhydrazine, and corticosteroids will be administered according to each clinical situation. Radical surgery followed by radical radiotherapy is reserved for primary lymphatic involvement only in specially selected patients in stage I with unifocal lesions. Primary involvement of the stomach, small bowel or colon is treated by surgical extirpation and radiotherapy. Splenectomy is indicated when this viscus is the only site of involvement. During pregnancy radiation therapy is not administered below the diaphragm. Chemotherapy is not given during the first 4 months of pregnancy. The need for one internationally accepted clinical classification of Hodgkin's disease is stressed." @default.
• W2415325853 created "2016-06-24" @default.
• W2415325853 creator A5014056620 @default.
• W2415325853 creator A5058613169 @default.
• W2415325853 creator A5059769118 @default.
• W2415325853 creator A5064460682 @default.
• W2415325853 creator A5065678804 @default.
• W2415325853 creator A5074531578 @default.
• W2415325853 creator A5075598337 @default.
• W2415325853 creator A5077119963 @default.
• W2415325853 creator A5090577710 @default.
• W2415325853 date "1965-03-01" @default.
• W2415325853 modified "2023-09-23" @default.
• W2415325853 title "Classification and Treatment of Hodgkin's Disease" @default.
• W2415325853 cites W1970077465 @default.
• W2415325853 cites W1975709841 @default.
• W2415325853 cites W1983295517 @default.
• W2415325853 cites W1983627189 @default.
• W2415325853 cites W1988472202 @default.
• W2415325853 cites W1992760728 @default.
• W2415325853 cites W2005163893 @default.
• W2415325853 cites W2007193560 @default.
• W2415325853 cites W2009800894 @default.
• W2415325853 cites W2012305037 @default.
• W2415325853 cites W2016530652 @default.
• W2415325853 cites W2041091586 @default.
• W2415325853 cites W2063487658 @default.
• W2415325853 cites W2066289919 @default.
• W2415325853 cites W2068742017 @default.
• W2415325853 cites W2078575811 @default.
• W2415325853 cites W2083343046 @default.
• W2415325853 cites W2083763825 @default.
• W2415325853 cites W2090937785 @default.
• W2415325853 cites W2107988590 @default.
• W2415325853 cites W2125550266 @default.
• W2415325853 cites W2169628489 @default.
• W2415325853 cites W2324832779 @default.
• W2415325853 cites W2341939530 @default.
• W2415325853 cites W2420099508 @default.
• W2415325853 cites W2983619348 @default.
• W2415325853 doi "https://doi.org/10.1177/030089166505100203" @default.
• W2415325853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14337661" @default.
• W2415325853 hasPublicationYear "1965" @default.
• W2415325853 type Work @default.
• W2415325853 sameAs 2415325853 @default.
• W2415325853 citedByCount "16" @default.
• W2415325853 countsByYear W24153258532014 @default.
• W2415325853 countsByYear W24153258532020 @default.
• W2415325853 crossrefType "journal-article" @default.
• W2415325853 hasAuthorship W2415325853A5014056620 @default.
• W2415325853 hasAuthorship W2415325853A5058613169 @default.
• W2415325853 hasAuthorship W2415325853A5059769118 @default.
• W2415325853 hasAuthorship W2415325853A5064460682 @default.
• W2415325853 hasAuthorship W2415325853A5065678804 @default.
• W2415325853 hasAuthorship W2415325853A5074531578 @default.
• W2415325853 hasAuthorship W2415325853A5075598337 @default.
• W2415325853 hasAuthorship W2415325853A5077119963 @default.
• W2415325853 hasAuthorship W2415325853A5090577710 @default.
• W2415325853 hasConcept C142724271 @default.
• W2415325853 hasConcept C146357865 @default.
• W2415325853 hasConcept C151730666 @default.
• W2415325853 hasConcept C181152851 @default.
• W2415325853 hasConcept C2779134260 @default.
• W2415325853 hasConcept C2779720271 @default.
• W2415325853 hasConcept C2780849966 @default.
• W2415325853 hasConcept C71924100 @default.
• W2415325853 hasConcept C86803240 @default.
• W2415325853 hasConceptScore W2415325853C142724271 @default.
• W2415325853 hasConceptScore W2415325853C146357865 @default.
• W2415325853 hasConceptScore W2415325853C151730666 @default.
• W2415325853 hasConceptScore W2415325853C181152851 @default.
• W2415325853 hasConceptScore W2415325853C2779134260 @default.
• W2415325853 hasConceptScore W2415325853C2779720271 @default.
• W2415325853 hasConceptScore W2415325853C2780849966 @default.
• W2415325853 hasConceptScore W2415325853C71924100 @default.
• W2415325853 hasConceptScore W2415325853C86803240 @default.
• W2415325853 hasIssue "2" @default.
• W2415325853 hasLocation W24153258531 @default.
• W2415325853 hasLocation W24153258532 @default.
• W2415325853 hasOpenAccess W2415325853 @default.
• W2415325853 hasPrimaryLocation W24153258531 @default.
• W2415325853 hasRelatedWork W1966798989 @default.
• W2415325853 hasRelatedWork W2004851132 @default.
• W2415325853 hasRelatedWork W2087036068 @default.
• W2415325853 hasRelatedWork W2333468506 @default.
• W2415325853 hasRelatedWork W2406011238 @default.
• W2415325853 hasRelatedWork W2757620043 @default.
• W2415325853 hasRelatedWork W3033878527 @default.
• W2415325853 hasRelatedWork W4213295501 @default.
• W2415325853 hasRelatedWork W4312841609 @default.
• W2415325853 hasRelatedWork W73074270 @default.
• W2415325853 hasVolume "51" @default.
• W2415325853 isParatext "false" @default.
• W2415325853 isRetracted "false" @default.
• W2415325853 magId "2415325853" @default.
• W2415325853 workType "article" @default.