Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415348569> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2415348569 endingPage "84" @default.
- W2415348569 startingPage "270" @default.
- W2415348569 abstract "Although hypoxia has been known for decades to play an important role in the outcome of radiotherapy in oncology, and inspite of the contribution of hypoxia to a myriad of pathologies that involve vascular disease, the selective imaging of hypoxic tissue has attained prominence only within the past decade. Contemporary research in the hypoxia imaging field is based largely on radiosensitizer research of the 1960's and 1970's. Early sensitizer research identified a family of nitro-organic compounds, the N-1 substituted 2-nitroimidazoles as candidate drugs. The early champion, and still the reference standard for therapeutic radiosensitization of hypoxic tumor cells is misonidazole (MISO). Its peripheral neurotoxicity led to failure in clinical studies, but its biological, biophysical and biochemical properties have been investigated in detail and serve as a basis for further design, not only of sensitizers, but of diagnostic radiopharmaceuticals for imaging tissue hypoxia. Pharmacokinetic characterization of radiopharmaceuticals, specifically radiopharmaceuticals for imaging tissue hypoxia, has not been a central theme in their development. The advent of PET, through which quantitative determinations first became possible, opened the field for both descriptive and analytical radiopharmacokinetic studies. In SPECT, however, this approach is still undergoing refinement. This paper addresses some of the underlying issues in radiopharmaceutical pharmacokinetics. There is a paucity of published radiopharmacokinetic data for SPECT hypoxia imaging agents. Consequently, the pharmacokinetic issues for MISO are presented as a basis for development of pharmacokinetics for the chemically-related imaging agents. Properties of an hypoxia marker are described from a pharmacokinetic viewpoint, a theoretical model for descriptive pharmacokinetics is introduced and finally, recent pharmacokinetic studies from our laboratory are described." @default.
- W2415348569 created "2016-06-24" @default.
- W2415348569 creator A5035258562 @default.
- W2415348569 creator A5088597633 @default.
- W2415348569 date "1996-09-01" @default.
- W2415348569 modified "2023-09-23" @default.
- W2415348569 title "Pharmacokinetics of SPECT radiopharmaceuticals for imaging hypoxic tissues." @default.
- W2415348569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8961804" @default.
- W2415348569 hasPublicationYear "1996" @default.
- W2415348569 type Work @default.
- W2415348569 sameAs 2415348569 @default.
- W2415348569 citedByCount "7" @default.
- W2415348569 crossrefType "journal-article" @default.
- W2415348569 hasAuthorship W2415348569A5035258562 @default.
- W2415348569 hasAuthorship W2415348569A5088597633 @default.
- W2415348569 hasConcept C112705442 @default.
- W2415348569 hasConcept C126322002 @default.
- W2415348569 hasConcept C178790620 @default.
- W2415348569 hasConcept C185592680 @default.
- W2415348569 hasConcept C202751555 @default.
- W2415348569 hasConcept C2776428644 @default.
- W2415348569 hasConcept C2779081379 @default.
- W2415348569 hasConcept C2781305896 @default.
- W2415348569 hasConcept C2984398910 @default.
- W2415348569 hasConcept C2989005 @default.
- W2415348569 hasConcept C509974204 @default.
- W2415348569 hasConcept C540031477 @default.
- W2415348569 hasConcept C55493867 @default.
- W2415348569 hasConcept C71924100 @default.
- W2415348569 hasConcept C7836513 @default.
- W2415348569 hasConcept C98274493 @default.
- W2415348569 hasConceptScore W2415348569C112705442 @default.
- W2415348569 hasConceptScore W2415348569C126322002 @default.
- W2415348569 hasConceptScore W2415348569C178790620 @default.
- W2415348569 hasConceptScore W2415348569C185592680 @default.
- W2415348569 hasConceptScore W2415348569C202751555 @default.
- W2415348569 hasConceptScore W2415348569C2776428644 @default.
- W2415348569 hasConceptScore W2415348569C2779081379 @default.
- W2415348569 hasConceptScore W2415348569C2781305896 @default.
- W2415348569 hasConceptScore W2415348569C2984398910 @default.
- W2415348569 hasConceptScore W2415348569C2989005 @default.
- W2415348569 hasConceptScore W2415348569C509974204 @default.
- W2415348569 hasConceptScore W2415348569C540031477 @default.
- W2415348569 hasConceptScore W2415348569C55493867 @default.
- W2415348569 hasConceptScore W2415348569C71924100 @default.
- W2415348569 hasConceptScore W2415348569C7836513 @default.
- W2415348569 hasConceptScore W2415348569C98274493 @default.
- W2415348569 hasIssue "3" @default.
- W2415348569 hasLocation W24153485691 @default.
- W2415348569 hasOpenAccess W2415348569 @default.
- W2415348569 hasPrimaryLocation W24153485691 @default.
- W2415348569 hasRelatedWork W1972529932 @default.
- W2415348569 hasRelatedWork W1985011289 @default.
- W2415348569 hasRelatedWork W1997112823 @default.
- W2415348569 hasRelatedWork W2015463545 @default.
- W2415348569 hasRelatedWork W2022234082 @default.
- W2415348569 hasRelatedWork W2028652202 @default.
- W2415348569 hasRelatedWork W2110122875 @default.
- W2415348569 hasRelatedWork W2415348569 @default.
- W2415348569 hasRelatedWork W284737299 @default.
- W2415348569 hasRelatedWork W4212936799 @default.
- W2415348569 hasVolume "40" @default.
- W2415348569 isParatext "false" @default.
- W2415348569 isRetracted "false" @default.
- W2415348569 magId "2415348569" @default.
- W2415348569 workType "article" @default.