Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415381687> ?p ?o ?g. }
- W2415381687 endingPage "457" @default.
- W2415381687 startingPage "444" @default.
- W2415381687 abstract "Conserved DNA-damage responses (DDRs) sense genome damage and prevent mitosis of broken chromosomes. How cells lacking DDRs cope with broken chromosomes during mitosis is poorly understood. DDRs are frequently inactivated in cells with extra genomes (polyploidy), suggesting that study of polyploidy can reveal how cells with impaired DDRs/genome damage continue dividing. Here, we show that continued division and normal organ development occurs in polyploid, DDR-impaired Drosophila papillar cells. As papillar cells become polyploid, they naturally accumulate broken acentric chromosomes but do not apoptose/arrest the cell cycle. To survive mitosis with acentric chromosomes, papillar cells require Fanconi anemia proteins FANCD2 and FANCI, as well as Blm helicase, but not canonical DDR signaling. FANCD2 acts independently of previous S phases to promote alignment and segregation of acentric DNA produced by double-strand breaks, thus avoiding micronuclei and organ malformation. Because polyploidy and impaired DDRs can promote cancer, our findings provide insight into disease-relevant DNA-damage tolerance mechanisms." @default.
- W2415381687 created "2016-06-24" @default.
- W2415381687 creator A5017026058 @default.
- W2415381687 creator A5045916438 @default.
- W2415381687 date "2016-06-01" @default.
- W2415381687 modified "2023-10-12" @default.
- W2415381687 title "Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2" @default.
- W2415381687 cites W1507334568 @default.
- W2415381687 cites W1548202728 @default.
- W2415381687 cites W1567713924 @default.
- W2415381687 cites W1601755300 @default.
- W2415381687 cites W1926771384 @default.
- W2415381687 cites W1965749659 @default.
- W2415381687 cites W1969127943 @default.
- W2415381687 cites W1970442105 @default.
- W2415381687 cites W1972154635 @default.
- W2415381687 cites W1973965906 @default.
- W2415381687 cites W1981339480 @default.
- W2415381687 cites W1985683054 @default.
- W2415381687 cites W1989892906 @default.
- W2415381687 cites W2004174191 @default.
- W2415381687 cites W2018530807 @default.
- W2415381687 cites W2019086038 @default.
- W2415381687 cites W2024605898 @default.
- W2415381687 cites W2025088179 @default.
- W2415381687 cites W2027966589 @default.
- W2415381687 cites W2029468690 @default.
- W2415381687 cites W2032414669 @default.
- W2415381687 cites W2036643322 @default.
- W2415381687 cites W2038850847 @default.
- W2415381687 cites W2047292328 @default.
- W2415381687 cites W2053779322 @default.
- W2415381687 cites W2065422258 @default.
- W2415381687 cites W2070397708 @default.
- W2415381687 cites W2079418641 @default.
- W2415381687 cites W2086333179 @default.
- W2415381687 cites W2087505934 @default.
- W2415381687 cites W2094783662 @default.
- W2415381687 cites W2095617425 @default.
- W2415381687 cites W2101185225 @default.
- W2415381687 cites W2102941656 @default.
- W2415381687 cites W2103921650 @default.
- W2415381687 cites W2105284425 @default.
- W2415381687 cites W2110938265 @default.
- W2415381687 cites W2114535878 @default.
- W2415381687 cites W2117692326 @default.
- W2415381687 cites W2119626690 @default.
- W2415381687 cites W2120881348 @default.
- W2415381687 cites W2121212012 @default.
- W2415381687 cites W2121436458 @default.
- W2415381687 cites W2123802255 @default.
- W2415381687 cites W2130060141 @default.
- W2415381687 cites W2131229657 @default.
- W2415381687 cites W2131247747 @default.
- W2415381687 cites W2134498862 @default.
- W2415381687 cites W2135830250 @default.
- W2415381687 cites W2142111793 @default.
- W2415381687 cites W2142544392 @default.
- W2415381687 cites W2144454035 @default.
- W2415381687 cites W2146993368 @default.
- W2415381687 cites W2148076560 @default.
- W2415381687 cites W2149304739 @default.
- W2415381687 cites W2150152073 @default.
- W2415381687 cites W2155261738 @default.
- W2415381687 cites W2155362972 @default.
- W2415381687 cites W2155995453 @default.
- W2415381687 cites W2157310482 @default.
- W2415381687 cites W2164963347 @default.
- W2415381687 cites W2166642585 @default.
- W2415381687 cites W2166834621 @default.
- W2415381687 cites W2167783541 @default.
- W2415381687 cites W2167844213 @default.
- W2415381687 cites W2187574279 @default.
- W2415381687 cites W2267929441 @default.
- W2415381687 cites W2419566688 @default.
- W2415381687 doi "https://doi.org/10.1016/j.devcel.2016.05.004" @default.
- W2415381687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4901310" @default.
- W2415381687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27270041" @default.
- W2415381687 hasPublicationYear "2016" @default.
- W2415381687 type Work @default.
- W2415381687 sameAs 2415381687 @default.
- W2415381687 citedByCount "36" @default.
- W2415381687 countsByYear W24153816872016 @default.
- W2415381687 countsByYear W24153816872017 @default.
- W2415381687 countsByYear W24153816872018 @default.
- W2415381687 countsByYear W24153816872019 @default.
- W2415381687 countsByYear W24153816872020 @default.
- W2415381687 countsByYear W24153816872021 @default.
- W2415381687 countsByYear W24153816872022 @default.
- W2415381687 countsByYear W24153816872023 @default.
- W2415381687 crossrefType "journal-article" @default.
- W2415381687 hasAuthorship W2415381687A5017026058 @default.
- W2415381687 hasAuthorship W2415381687A5045916438 @default.
- W2415381687 hasBestOaLocation W24153816871 @default.
- W2415381687 hasConcept C134935766 @default.
- W2415381687 hasConcept C143425029 @default.
- W2415381687 hasConcept C178169997 @default.
- W2415381687 hasConcept C2776653068 @default.