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- W2415396529 abstract "Micro RNA regulation of transcript expression has been reported in patients with Alzheimer's disease ( AD ). Here, we investigate the role of micro RNA ‐146a (mi RNA ‐146a), a brain‐enriched mi RNA , which is upregulated in AD patients. Through analysis of predicted targets of mi RNA ‐146a, low‐density lipoprotein receptor‐related protein‐2 (Lrp2), a member of the LDLR family that is known to play a protective role in AD , was identified. Overexpression of mi RNA ‐146a in SH ‐ SY 5Y cells significantly decreased Lrp2 expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase‐3, thereby increasing cell apoptosis. Thus, specific mi RNA ‐146a regulation may contribute to AD by downregulating the Lrp2/Akt pathway." @default.
- W2415396529 created "2016-06-24" @default.
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- W2415396529 date "2016-07-01" @default.
- W2415396529 modified "2023-10-15" @default.
- W2415396529 title "MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease" @default.
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- W2415396529 doi "https://doi.org/10.1002/1873-3468.12229" @default.
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