FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415408840> ?p ?o ?g. }

• W2415408840 abstract "As the world's population continues to age, it is estimated that degenerative joint disease disorders such as osteoarthritis will impact at least 130 million individuals throughout the globe by the year 2050. Advanced age, obesity, genetics, gender, bone density, trauma, and a poor level of physical activity can lead to the onset and progression of osteoarthritis. However, factors that lead to degenerative joint disease and involve gender, genetics, epigenetic mechanisms, and advanced age are not within the control of an individual. Furthermore, current therapies including pain management, improved nutrition, and regular programs for exercise do not lead to the resolution of osteoarthritis. As a result, new avenues for targeting the treatment of osteoarthritis are desperately needed. Wnt1 inducible signaling pathway protein 1 (WISP1), a matricellular protein and a downstream target of the wingless pathway Wnt1, is one such target to consider that governs cellular protection, stem cell proliferation, and tissue regeneration in a number of disorders including bone degeneration. However, increased WISP1 expression also has been associated with the progression of osteoarthritis. WISP1 has an intricate relationship with a number of proliferative and protective pathways that include phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interleukin -6 (IL-6), transforming growth factor-β, matrix metalloproteinase, small non-coding ribonucleic acids (RNAs), sirtuin silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), and the mechanistic target of rapamycin (mTOR). Taken together, this complex association WISP1 holds with these signaling pathways necessitates a fine biological regulation of WISP1 activity that can offset the progression of degenerative joint disease, but not limit the cellular protective capabilities of the WISP1 pathway." @default.
• W2415408840 created "2016-06-24" @default.
• W2415408840 creator A5000415542 @default.
• W2415408840 date "2016-01-01" @default.
• W2415408840 modified "2023-10-15" @default.
• W2415408840 title "Picking a bone with WISP1 (CCN4): new strategies against degenerative joint disease" @default.
• W2415408840 cites W1580081728 @default.
• W2415408840 cites W1582105160 @default.
• W2415408840 cites W1599253395 @default.
• W2415408840 cites W1836558695 @default.
• W2415408840 cites W1910037588 @default.
• W2415408840 cites W1944215271 @default.
• W2415408840 cites W1963797187 @default.
• W2415408840 cites W1984444346 @default.
• W2415408840 cites W1985260356 @default.
• W2415408840 cites W1985362243 @default.
• W2415408840 cites W1989870864 @default.
• W2415408840 cites W1995111986 @default.
• W2415408840 cites W1999963870 @default.
• W2415408840 cites W2003686137 @default.
• W2415408840 cites W2011400357 @default.
• W2415408840 cites W2033912925 @default.
• W2415408840 cites W2043263334 @default.
• W2415408840 cites W2046575296 @default.
• W2415408840 cites W2055559862 @default.
• W2415408840 cites W2056463155 @default.
• W2415408840 cites W2057826382 @default.
• W2415408840 cites W2072343891 @default.
• W2415408840 cites W2085316373 @default.
• W2415408840 cites W2099032267 @default.
• W2415408840 cites W2099769695 @default.
• W2415408840 cites W2101492172 @default.
• W2415408840 cites W2103530035 @default.
• W2415408840 cites W2115887130 @default.
• W2415408840 cites W2136447800 @default.
• W2415408840 cites W2148749512 @default.
• W2415408840 cites W2149929597 @default.
• W2415408840 cites W2151257384 @default.
• W2415408840 cites W2155738520 @default.
• W2415408840 cites W2162110846 @default.
• W2415408840 cites W2170396987 @default.
• W2415408840 cites W2177415154 @default.
• W2415408840 cites W2210356132 @default.
• W2415408840 cites W2338606193 @default.
• W2415408840 cites W279480694 @default.
• W2415408840 doi "https://doi.org/10.15761/jts.1000120" @default.
• W2415408840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4755495" @default.
• W2415408840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26893943" @default.
• W2415408840 hasPublicationYear "2016" @default.
• W2415408840 type Work @default.
• W2415408840 sameAs 2415408840 @default.
• W2415408840 citedByCount "33" @default.
• W2415408840 countsByYear W24154088402016 @default.
• W2415408840 countsByYear W24154088402017 @default.
• W2415408840 countsByYear W24154088402018 @default.
• W2415408840 countsByYear W24154088402019 @default.
• W2415408840 countsByYear W24154088402020 @default.
• W2415408840 countsByYear W24154088402021 @default.
• W2415408840 countsByYear W24154088402022 @default.
• W2415408840 countsByYear W24154088402023 @default.
• W2415408840 crossrefType "journal-article" @default.
• W2415408840 hasAuthorship W2415408840A5000415542 @default.
• W2415408840 hasBestOaLocation W24154088401 @default.
• W2415408840 hasConcept C104317684 @default.
• W2415408840 hasConcept C142724271 @default.
• W2415408840 hasConcept C204787440 @default.
• W2415408840 hasConcept C2776164576 @default.
• W2415408840 hasConcept C41091548 @default.
• W2415408840 hasConcept C502942594 @default.
• W2415408840 hasConcept C54355233 @default.
• W2415408840 hasConcept C60644358 @default.
• W2415408840 hasConcept C62478195 @default.
• W2415408840 hasConcept C71924100 @default.
• W2415408840 hasConcept C75217442 @default.
• W2415408840 hasConcept C86554907 @default.
• W2415408840 hasConcept C86803240 @default.
• W2415408840 hasConcept C95444343 @default.
• W2415408840 hasConceptScore W2415408840C104317684 @default.
• W2415408840 hasConceptScore W2415408840C142724271 @default.
• W2415408840 hasConceptScore W2415408840C204787440 @default.
• W2415408840 hasConceptScore W2415408840C2776164576 @default.
• W2415408840 hasConceptScore W2415408840C41091548 @default.
• W2415408840 hasConceptScore W2415408840C502942594 @default.
• W2415408840 hasConceptScore W2415408840C54355233 @default.
• W2415408840 hasConceptScore W2415408840C60644358 @default.
• W2415408840 hasConceptScore W2415408840C62478195 @default.
• W2415408840 hasConceptScore W2415408840C71924100 @default.
• W2415408840 hasConceptScore W2415408840C75217442 @default.
• W2415408840 hasConceptScore W2415408840C86554907 @default.
• W2415408840 hasConceptScore W2415408840C86803240 @default.
• W2415408840 hasConceptScore W2415408840C95444343 @default.
• W2415408840 hasIssue "1" @default.
• W2415408840 hasLocation W24154088401 @default.
• W2415408840 hasLocation W24154088402 @default.
• W2415408840 hasOpenAccess W2415408840 @default.
• W2415408840 hasPrimaryLocation W24154088401 @default.
• W2415408840 hasRelatedWork W2024933597 @default.
• W2415408840 hasRelatedWork W2070783513 @default.
• W2415408840 hasRelatedWork W2098584395 @default.
• W2415408840 hasRelatedWork W2422815049 @default.

• next