Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415435788> ?p ?o ?g. }
- W2415435788 endingPage "166" @default.
- W2415435788 startingPage "155" @default.
- W2415435788 abstract "The treatment of soft tissue sarcoma (STS) generally involves tumor excision with a wide margin. Although advances in fluorescence imaging make real-time detection of cancer possible, removal is limited by the precision of the human eye and hand. Here, we describe a novel pulsed Nd:YAG laser ablation system that, when used in conjunction with a previously described molecular imaging system, can identify and ablate cancer in vivo. Mice with primary STS were injected with the protease-activatable probe LUM015 to label tumors. Resected tissues from the mice were then imaged and treated with the laser using the paired fluorescence-imaging/ laser ablation device, generating ablation clefts with sub-millimeter precision and minimal underlying tissue damage. Laser ablation was guided by fluorescence to target tumor tissues, avoiding normal structures. The selective ablation of tumor implants in vivo improved recurrence-free survival after tumor resection in a cohort of 14 mice compared to 12 mice that received no ablative therapy. This prototype system has the potential to be modified so that it can be used during surgery to improve recurrence-free survival in patients with cancer." @default.
- W2415435788 created "2016-06-24" @default.
- W2415435788 creator A5005903784 @default.
- W2415435788 creator A5010673147 @default.
- W2415435788 creator A5019817130 @default.
- W2415435788 creator A5026684297 @default.
- W2415435788 creator A5045599896 @default.
- W2415435788 creator A5056480805 @default.
- W2415435788 creator A5056839876 @default.
- W2415435788 creator A5068178694 @default.
- W2415435788 creator A5070216920 @default.
- W2415435788 creator A5072509000 @default.
- W2415435788 creator A5079219278 @default.
- W2415435788 creator A5081989505 @default.
- W2415435788 date "2016-01-01" @default.
- W2415435788 modified "2023-10-17" @default.
- W2415435788 title "A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma" @default.
- W2415435788 cites W1487236078 @default.
- W2415435788 cites W1512285776 @default.
- W2415435788 cites W1558453863 @default.
- W2415435788 cites W1560056785 @default.
- W2415435788 cites W1724512254 @default.
- W2415435788 cites W1878715328 @default.
- W2415435788 cites W1941095565 @default.
- W2415435788 cites W1966409101 @default.
- W2415435788 cites W1967326319 @default.
- W2415435788 cites W1972308429 @default.
- W2415435788 cites W1974958006 @default.
- W2415435788 cites W1980738763 @default.
- W2415435788 cites W1989940649 @default.
- W2415435788 cites W1994772304 @default.
- W2415435788 cites W1995208714 @default.
- W2415435788 cites W1999891600 @default.
- W2415435788 cites W2007179675 @default.
- W2415435788 cites W2019384302 @default.
- W2415435788 cites W2019681593 @default.
- W2415435788 cites W2028187795 @default.
- W2415435788 cites W2028524759 @default.
- W2415435788 cites W2034762861 @default.
- W2415435788 cites W2050358188 @default.
- W2415435788 cites W2053215710 @default.
- W2415435788 cites W2069444182 @default.
- W2415435788 cites W2072765609 @default.
- W2415435788 cites W2084601581 @default.
- W2415435788 cites W2095467773 @default.
- W2415435788 cites W2098384648 @default.
- W2415435788 cites W2102133043 @default.
- W2415435788 cites W2124453937 @default.
- W2415435788 cites W2125372543 @default.
- W2415435788 cites W2142020978 @default.
- W2415435788 cites W2143405185 @default.
- W2415435788 cites W2148279955 @default.
- W2415435788 cites W2156590390 @default.
- W2415435788 cites W2240104466 @default.
- W2415435788 doi "https://doi.org/10.7150/thno.13536" @default.
- W2415435788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4729765" @default.
- W2415435788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26877775" @default.
- W2415435788 hasPublicationYear "2016" @default.
- W2415435788 type Work @default.
- W2415435788 sameAs 2415435788 @default.
- W2415435788 citedByCount "19" @default.
- W2415435788 countsByYear W24154357882016 @default.
- W2415435788 countsByYear W24154357882017 @default.
- W2415435788 countsByYear W24154357882018 @default.
- W2415435788 countsByYear W24154357882019 @default.
- W2415435788 countsByYear W24154357882020 @default.
- W2415435788 countsByYear W24154357882021 @default.
- W2415435788 countsByYear W24154357882022 @default.
- W2415435788 countsByYear W24154357882023 @default.
- W2415435788 crossrefType "journal-article" @default.
- W2415435788 hasAuthorship W2415435788A5005903784 @default.
- W2415435788 hasAuthorship W2415435788A5010673147 @default.
- W2415435788 hasAuthorship W2415435788A5019817130 @default.
- W2415435788 hasAuthorship W2415435788A5026684297 @default.
- W2415435788 hasAuthorship W2415435788A5045599896 @default.
- W2415435788 hasAuthorship W2415435788A5056480805 @default.
- W2415435788 hasAuthorship W2415435788A5056839876 @default.
- W2415435788 hasAuthorship W2415435788A5068178694 @default.
- W2415435788 hasAuthorship W2415435788A5070216920 @default.
- W2415435788 hasAuthorship W2415435788A5072509000 @default.
- W2415435788 hasAuthorship W2415435788A5079219278 @default.
- W2415435788 hasAuthorship W2415435788A5081989505 @default.
- W2415435788 hasBestOaLocation W24154357881 @default.
- W2415435788 hasConcept C120665830 @default.
- W2415435788 hasConcept C121332964 @default.
- W2415435788 hasConcept C121608353 @default.
- W2415435788 hasConcept C126322002 @default.
- W2415435788 hasConcept C136229726 @default.
- W2415435788 hasConcept C136948725 @default.
- W2415435788 hasConcept C142724271 @default.
- W2415435788 hasConcept C150903083 @default.
- W2415435788 hasConcept C192562407 @default.
- W2415435788 hasConcept C207001950 @default.
- W2415435788 hasConcept C2778256501 @default.
- W2415435788 hasConcept C2778629024 @default.
- W2415435788 hasConcept C2778902805 @default.
- W2415435788 hasConcept C2779188808 @default.
- W2415435788 hasConcept C520434653 @default.