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• W2415439056 endingPage "E680" @default.
• W2415439056 startingPage "E675" @default.
• W2415439056 abstract "Binding of atrial natriuretic peptide (ANP) to rat submandibular gland and its effect on guanosine 3',5'-cyclic monophosphate (cGMP) formation and salivary secretion were investigated. Membranes rapidly and specifically bound 125I-ANP. Binding was inhibited by unlabeled ANP (IC50 approximately 1.6 nM), but not by atriopeptin I, other COOH- and NH2-terminal deleted ANP fragments, or agents such as pilocarpine or substance P. Scatchard analysis revealed a single class of high-affinity sites (dissociation constant 0.74 +/- 0.25 nM; maximal binding capacity 20.5 +/- 6.3 pmol/mg protein). Intravenous infusion of ANP with pilocarpine caused a significant dose-dependent increase in the levels of cGMP detected in plasma and saliva. Because salivary cGMP may have originated in plasma, the effect of ANP on cGMP formation was evaluated in dispersed cells. ANP evoked a concentration-dependent increase in both cGMP synthesis and secretion (EC50 approximately 1.7 x 10(-8) M). The atrial peptide did affect basal or l-isoproterenol-stimulated adenosine 3',5'-cyclic monophosphate synthesis in dispersed cells. When infused by itself and/or with pilocarpine, ANP did not alter the rate of spontaneous or pilocarpine-induced salivary flow, secretion of chloride, or protein release. The data demonstrate the presence of guanylate cyclase-coupled ANP receptors in submandibular gland; the atrial peptide, however, does not exert an effect of the secretory function of the gland." @default.
• W2415439056 created "2016-06-24" @default.
• W2415439056 creator A5007735153 @default.
• W2415439056 creator A5023113978 @default.
• W2415439056 creator A5036564708 @default.
• W2415439056 date "1989-11-01" @default.
• W2415439056 modified "2023-09-28" @default.
• W2415439056 title "Atrial natriuretic peptide stimulates submandibular gland synthesis and secretion of cGMP" @default.
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• W2415439056 doi "https://doi.org/10.1152/ajpendo.1989.257.5.e675" @default.
• W2415439056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2556937" @default.
• W2415439056 hasPublicationYear "1989" @default.
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