Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415442265> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2415442265 endingPage "E390" @default.
- W2415442265 startingPage "E380" @default.
- W2415442265 abstract "We performed euglycemic hyperinsulinemic glucose clamps at insulin infusion rates of 1.9, 4.0, 9.3, and 19.3 mU.kg-1 x min-1 in rats with varying severities of iron deficiency anemia (IDA; mean hemoglobin concentrations of 59, 79, 107, and 137 g/l) to assess the effect of IDA on insulin sensitivity and responsiveness. Glucose appearance and disappearance (Rd) rates were determined using a primed continuous infusion of [3-3H]glucose. Basal plasma glucose and insulin concentrations were similar between the IDA and control rats. Basal hepatic glucose production was significantly (P = 0.0001) elevated in the two most anemic groups (13.6 +/- 2.4 and 12.6 +/- 3.1 vs. 10.6 +/- 2.2 and 10.2 +/- 2.0 mg.kg-1 x min-1). A significant upward shift in the insulin dose-response curves for Rd indicated an increase in peripheral insulin responsiveness in the two most anemic groups while a slight leftward shift was suggestive of an increase in insulin sensitivity in all three anemic groups. Hepatic insulin sensitivity and responsiveness were unaffected by IDA. We conclude that increased glucose utilization rates in IDA rats are due primarily to an increase in peripheral insulin responsiveness." @default.
- W2415442265 created "2016-06-24" @default.
- W2415442265 creator A5001773905 @default.
- W2415442265 creator A5044133666 @default.
- W2415442265 creator A5084572698 @default.
- W2415442265 date "1993-03-01" @default.
- W2415442265 modified "2023-09-25" @default.
- W2415442265 title "Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats" @default.
- W2415442265 cites W1482809398 @default.
- W2415442265 cites W1527522123 @default.
- W2415442265 cites W1905245030 @default.
- W2415442265 cites W1958289030 @default.
- W2415442265 cites W2002537454 @default.
- W2415442265 cites W2017888726 @default.
- W2415442265 cites W2023056644 @default.
- W2415442265 cites W2060681981 @default.
- W2415442265 cites W2080944583 @default.
- W2415442265 cites W2111040033 @default.
- W2415442265 cites W2125127617 @default.
- W2415442265 cites W2129694420 @default.
- W2415442265 cites W2135666165 @default.
- W2415442265 cites W2141632259 @default.
- W2415442265 cites W2148841816 @default.
- W2415442265 cites W2164471793 @default.
- W2415442265 cites W2169401893 @default.
- W2415442265 cites W2179432655 @default.
- W2415442265 cites W2313698713 @default.
- W2415442265 cites W2397594219 @default.
- W2415442265 cites W4231523688 @default.
- W2415442265 doi "https://doi.org/10.1152/ajpendo.1993.264.3.e380" @default.
- W2415442265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8460685" @default.
- W2415442265 hasPublicationYear "1993" @default.
- W2415442265 type Work @default.
- W2415442265 sameAs 2415442265 @default.
- W2415442265 citedByCount "22" @default.
- W2415442265 countsByYear W24154422652013 @default.
- W2415442265 countsByYear W24154422652014 @default.
- W2415442265 countsByYear W24154422652015 @default.
- W2415442265 countsByYear W24154422652016 @default.
- W2415442265 countsByYear W24154422652017 @default.
- W2415442265 countsByYear W24154422652018 @default.
- W2415442265 countsByYear W24154422652019 @default.
- W2415442265 countsByYear W24154422652020 @default.
- W2415442265 countsByYear W24154422652021 @default.
- W2415442265 countsByYear W24154422652022 @default.
- W2415442265 countsByYear W24154422652023 @default.
- W2415442265 crossrefType "journal-article" @default.
- W2415442265 hasAuthorship W2415442265A5001773905 @default.
- W2415442265 hasAuthorship W2415442265A5044133666 @default.
- W2415442265 hasAuthorship W2415442265A5084572698 @default.
- W2415442265 hasConcept C126322002 @default.
- W2415442265 hasConcept C134018914 @default.
- W2415442265 hasConcept C2777391703 @default.
- W2415442265 hasConcept C2778024521 @default.
- W2415442265 hasConcept C2778917026 @default.
- W2415442265 hasConcept C2779306644 @default.
- W2415442265 hasConcept C3017594256 @default.
- W2415442265 hasConcept C46762472 @default.
- W2415442265 hasConcept C71924100 @default.
- W2415442265 hasConceptScore W2415442265C126322002 @default.
- W2415442265 hasConceptScore W2415442265C134018914 @default.
- W2415442265 hasConceptScore W2415442265C2777391703 @default.
- W2415442265 hasConceptScore W2415442265C2778024521 @default.
- W2415442265 hasConceptScore W2415442265C2778917026 @default.
- W2415442265 hasConceptScore W2415442265C2779306644 @default.
- W2415442265 hasConceptScore W2415442265C3017594256 @default.
- W2415442265 hasConceptScore W2415442265C46762472 @default.
- W2415442265 hasConceptScore W2415442265C71924100 @default.
- W2415442265 hasIssue "3" @default.
- W2415442265 hasLocation W24154422651 @default.
- W2415442265 hasLocation W24154422652 @default.
- W2415442265 hasOpenAccess W2415442265 @default.
- W2415442265 hasPrimaryLocation W24154422651 @default.
- W2415442265 hasRelatedWork W138803513 @default.
- W2415442265 hasRelatedWork W1986132654 @default.
- W2415442265 hasRelatedWork W2010140898 @default.
- W2415442265 hasRelatedWork W2016328345 @default.
- W2415442265 hasRelatedWork W2048226041 @default.
- W2415442265 hasRelatedWork W2066345847 @default.
- W2415442265 hasRelatedWork W2068166803 @default.
- W2415442265 hasRelatedWork W2082140668 @default.
- W2415442265 hasRelatedWork W2430205611 @default.
- W2415442265 hasRelatedWork W4234612679 @default.
- W2415442265 hasVolume "264" @default.
- W2415442265 isParatext "false" @default.
- W2415442265 isRetracted "false" @default.
- W2415442265 magId "2415442265" @default.
- W2415442265 workType "article" @default.