FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415454851> ?p ?o ?g. }

• W2415454851 endingPage "30" @default.
• W2415454851 startingPage "125" @default.
• W2415454851 abstract "To explore the expression and significance of miRNAs and Th17 related cytokines in patients with multiple myeloma (MM).A total of 27 MM patients and 8 health controls were enrolled in this study. The expression of miR-15a/16,miR-34a,miR-194-2-192 cluster and miR-181a/b in bone marrow were detected by real-time quantitative PCR (qRT-PCR). Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of Th17 related cytokines interleukin-17 (IL-17), IL-21, IL-22, IL-23 and IL-27 in peripheral blood plasma. The role of miRNAs and Th17 related cytokines was analyzed in the development of MM.The expression of miR-15a/16,miR-34a,miR-194-2-192 cluster in MM patients were significantly lower than those of the health controls, while miR-181a/b were exactly the reverse (P<0.05). The levels of IL-17, IL-21 and IL-27 were up-regulated in MM patients compared to health controls while IL-22 was down-regulated (P<0.05). There was no significant difference of IL-23 between the two groups. The levels of miRNAs and Th17 related cytokines had associated with ISS but not with some clinical parameters (such as gender, age, disease classification). Higher expression of IL-17, IL-21, IL-23, IL-27, miR-181a/b and lower expression of miR-15a/16,miR-34a,miR-194 and IL-22 were observed in the end stage than the early stage of MM patients (P<0.05). There was a significant correlation between miRNAs and Th17 related cytokines.Up-regulated IL-17, IL-21 and IL-27 may potentially down-regulate the expression of several miRNAs in MM patients. Establishment of the relationship may be useful for understanding the pathogenesis of MM and for clinical diagnosis of the disease." @default.
• W2415454851 created "2016-06-24" @default.
• W2415454851 creator A5008795836 @default.
• W2415454851 creator A5011591592 @default.
• W2415454851 creator A5020302124 @default.
• W2415454851 creator A5025415458 @default.
• W2415454851 creator A5032808067 @default.
• W2415454851 creator A5037942759 @default.
• W2415454851 creator A5048129965 @default.
• W2415454851 creator A5065859712 @default.
• W2415454851 creator A5073709637 @default.
• W2415454851 creator A5082587315 @default.
• W2415454851 date "2015-02-01" @default.
• W2415454851 modified "2023-10-16" @default.
• W2415454851 title "[Potential relationship and clinical significance of miRNAs and Th17 related cytokines in patients with multiple myeloma]." @default.
• W2415454851 cites W1978431592 @default.
• W2415454851 cites W1992750664 @default.
• W2415454851 cites W1994246752 @default.
• W2415454851 cites W2002409863 @default.
• W2415454851 cites W2010570442 @default.
• W2415454851 cites W2028330103 @default.
• W2415454851 cites W2035263877 @default.
• W2415454851 cites W2055670205 @default.
• W2415454851 cites W2056320810 @default.
• W2415454851 cites W2062903634 @default.
• W2415454851 cites W2098636562 @default.
• W2415454851 cites W2113262521 @default.
• W2415454851 cites W2118720020 @default.
• W2415454851 cites W2121694847 @default.
• W2415454851 cites W2130136872 @default.
• W2415454851 cites W2141507689 @default.
• W2415454851 cites W2146483998 @default.
• W2415454851 cites W2149584454 @default.
• W2415454851 cites W2163433846 @default.
• W2415454851 cites W2165119095 @default.
• W2415454851 cites W2169745891 @default.
• W2415454851 doi "https://doi.org/10.3760/cma.j.issn.0253-2727.2015.02.009" @default.
• W2415454851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7342155" @default.
• W2415454851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25778888" @default.
• W2415454851 hasPublicationYear "2015" @default.
• W2415454851 type Work @default.
• W2415454851 sameAs 2415454851 @default.
• W2415454851 citedByCount "0" @default.
• W2415454851 crossrefType "journal-article" @default.
• W2415454851 hasAuthorship W2415454851A5008795836 @default.
• W2415454851 hasAuthorship W2415454851A5011591592 @default.
• W2415454851 hasAuthorship W2415454851A5020302124 @default.
• W2415454851 hasAuthorship W2415454851A5025415458 @default.
• W2415454851 hasAuthorship W2415454851A5032808067 @default.
• W2415454851 hasAuthorship W2415454851A5037942759 @default.
• W2415454851 hasAuthorship W2415454851A5048129965 @default.
• W2415454851 hasAuthorship W2415454851A5065859712 @default.
• W2415454851 hasAuthorship W2415454851A5073709637 @default.
• W2415454851 hasAuthorship W2415454851A5082587315 @default.
• W2415454851 hasConcept C104317684 @default.
• W2415454851 hasConcept C11988809 @default.
• W2415454851 hasConcept C126322002 @default.
• W2415454851 hasConcept C143998085 @default.
• W2415454851 hasConcept C145059251 @default.
• W2415454851 hasConcept C146357865 @default.
• W2415454851 hasConcept C151730666 @default.
• W2415454851 hasConcept C203014093 @default.
• W2415454851 hasConcept C2776364478 @default.
• W2415454851 hasConcept C2778690821 @default.
• W2415454851 hasConcept C47348012 @default.
• W2415454851 hasConcept C48023723 @default.
• W2415454851 hasConcept C55493867 @default.
• W2415454851 hasConcept C63363279 @default.
• W2415454851 hasConcept C71924100 @default.
• W2415454851 hasConcept C74172505 @default.
• W2415454851 hasConcept C86803240 @default.
• W2415454851 hasConceptScore W2415454851C104317684 @default.
• W2415454851 hasConceptScore W2415454851C11988809 @default.
• W2415454851 hasConceptScore W2415454851C126322002 @default.
• W2415454851 hasConceptScore W2415454851C143998085 @default.
• W2415454851 hasConceptScore W2415454851C145059251 @default.
• W2415454851 hasConceptScore W2415454851C146357865 @default.
• W2415454851 hasConceptScore W2415454851C151730666 @default.
• W2415454851 hasConceptScore W2415454851C203014093 @default.
• W2415454851 hasConceptScore W2415454851C2776364478 @default.
• W2415454851 hasConceptScore W2415454851C2778690821 @default.
• W2415454851 hasConceptScore W2415454851C47348012 @default.
• W2415454851 hasConceptScore W2415454851C48023723 @default.
• W2415454851 hasConceptScore W2415454851C55493867 @default.
• W2415454851 hasConceptScore W2415454851C63363279 @default.
• W2415454851 hasConceptScore W2415454851C71924100 @default.
• W2415454851 hasConceptScore W2415454851C74172505 @default.
• W2415454851 hasConceptScore W2415454851C86803240 @default.
• W2415454851 hasIssue "2" @default.
• W2415454851 hasLocation W24154548511 @default.
• W2415454851 hasOpenAccess W2415454851 @default.
• W2415454851 hasPrimaryLocation W24154548511 @default.
• W2415454851 hasRelatedWork W1978991749 @default.
• W2415454851 hasRelatedWork W2008026482 @default.
• W2415454851 hasRelatedWork W2046257669 @default.
• W2415454851 hasRelatedWork W2060769801 @default.
• W2415454851 hasRelatedWork W2100704659 @default.
• W2415454851 hasRelatedWork W2163202428 @default.

• next