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- W2415467107 abstract "Significant improvements in unrelated donor hematopoietic stem cell transplantation (HSCT) in recent years have solidified its therapeutic role in severe aplastic anemia (SAA) and led to the evolution of treatment algorithms, particularly for children.Advances in understanding the genetics of inherited bone marrow failure syndromes (IBMFS) have allowed more confidence in accurately diagnosing SAA and avoiding treatments that could be dangerous and ineffective in individuals with IBMFS, which can be diagnosed in 10-20% of children presenting with a picture of SAA. Additionally long-term survival after matched sibling donor and matched unrelated donor HSCT now exceed 90% in children. Late effects after HSCT for SAA are minimal with current strategies, and compare favorably to late effects after upfront immunosuppressive therapy, except for patients with chronic graft versus host disease.Careful assessment for signs or symptoms of IBMFS, along with genetic screening for these disorders, is of major importance. Matched sibling donor HSCT is already considered the standard of care for upfront therapy and some groups are evaluating matched unrelated donor HSCT as primary therapy. Ongoing studies will continue to challenge treatment algorithms and may lead to an even more expanded role for HSCT in SAA." @default.
- W2415467107 created "2016-06-24" @default.
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- W2415467107 date "2016-02-01" @default.
- W2415467107 modified "2023-09-28" @default.
- W2415467107 title "Evolving hematopoietic stem cell transplantation strategies in severe aplastic anemia" @default.
- W2415467107 cites W131854666 @default.
- W2415467107 cites W134880196 @default.
- W2415467107 cites W1517672097 @default.
- W2415467107 cites W1532949585 @default.
- W2415467107 cites W1600433770 @default.
- W2415467107 cites W1764263346 @default.
- W2415467107 cites W1764338921 @default.
- W2415467107 cites W1820573680 @default.
- W2415467107 cites W1832131714 @default.
- W2415467107 cites W185166649 @default.
- W2415467107 cites W1944989615 @default.
- W2415467107 cites W1968262670 @default.
- W2415467107 cites W1969849446 @default.
- W2415467107 cites W1970974307 @default.
- W2415467107 cites W1978782366 @default.
- W2415467107 cites W1988693031 @default.
- W2415467107 cites W1990941789 @default.
- W2415467107 cites W2010484076 @default.
- W2415467107 cites W2010859496 @default.
- W2415467107 cites W2011295270 @default.
- W2415467107 cites W2014549308 @default.
- W2415467107 cites W2018678214 @default.
- W2415467107 cites W2022396757 @default.
- W2415467107 cites W2023640756 @default.
- W2415467107 cites W2024481101 @default.
- W2415467107 cites W2025183952 @default.
- W2415467107 cites W2025416886 @default.
- W2415467107 cites W2028208596 @default.
- W2415467107 cites W2031437236 @default.
- W2415467107 cites W2036245297 @default.
- W2415467107 cites W2041446098 @default.
- W2415467107 cites W2047896708 @default.
- W2415467107 cites W2048147393 @default.
- W2415467107 cites W2048947906 @default.
- W2415467107 cites W2055865422 @default.
- W2415467107 cites W2056235669 @default.
- W2415467107 cites W2059088323 @default.
- W2415467107 cites W2060556025 @default.
- W2415467107 cites W2062443484 @default.
- W2415467107 cites W2068207723 @default.
- W2415467107 cites W2071159074 @default.
- W2415467107 cites W2073410844 @default.
- W2415467107 cites W2076509836 @default.
- W2415467107 cites W2076667162 @default.
- W2415467107 cites W2081316165 @default.
- W2415467107 cites W2082215517 @default.
- W2415467107 cites W2084236195 @default.
- W2415467107 cites W2084853335 @default.
- W2415467107 cites W2086129066 @default.
- W2415467107 cites W2090924602 @default.
- W2415467107 cites W2100809121 @default.
- W2415467107 cites W2100946177 @default.
- W2415467107 cites W2102953128 @default.
- W2415467107 cites W2106456757 @default.
- W2415467107 cites W2107947615 @default.
- W2415467107 cites W2119566322 @default.
- W2415467107 cites W2119591903 @default.
- W2415467107 cites W2127660435 @default.
- W2415467107 cites W2131799119 @default.
- W2415467107 cites W2133348027 @default.
- W2415467107 cites W2135819411 @default.
- W2415467107 cites W2142353478 @default.
- W2415467107 cites W2144377312 @default.
- W2415467107 cites W2149753414 @default.
- W2415467107 cites W2158837255 @default.
- W2415467107 cites W2160025789 @default.
- W2415467107 cites W2168731523 @default.
- W2415467107 cites W2171228629 @default.
- W2415467107 cites W2319873259 @default.
- W2415467107 cites W2403765098 @default.
- W2415467107 cites W2407798613 @default.
- W2415467107 cites W2460273409 @default.
- W2415467107 cites W2478483272 @default.
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- W2415467107 doi "https://doi.org/10.1097/mop.0000000000000299" @default.
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