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• W2415507798 startingPage "8804" @default.
• W2415507798 abstract "For investigation of the molecular interaction of cranberry extract with adhesins of uropathogenic Escherichia coli (UPEC), urine from four volunteers consuming standardized cranberry extract (proanthocyanidin content = 1.24%) was analyzed within ex vivo experiments, indicating time-dependent significant inhibition of 40–50% of bacterial adhesion of UPEC strain NU14 to human T24 bladder cells. Under in vitro conditions a dose-dependent increase in bacterial adhesion was observed with proanthocyanidin-enriched cranberry Vaccinium macrocarpon extract (proanthocyanidin content = 21%). Confocal laser scanning microscopy and scanning electron microscopy proved that V.m. extract led to the formation of bacterial clusters on the outer plasma membrane of the host cells without subsequent internalization. This agglomerating activity was not observed when a PAC-depleted extract (V.m. extract≠PAC) was used, which showed significant inhibition of bacterial adhesion in cases where type 1 fimbriae dominated and mannose-sensitive UPEC strain NU14 was used. V.m. extract≠PAC had no inhibitory activity against P- and F1C-fimbriae dominated strain 2980. Quantitative gene expression analysis indicated that PAC-containing as well as PAC-depleted cranberry extracts increased the fimH expression in NU14 as part of a feedback mechanism after blocking FimH. For strain 2980 the PAC-containing extract led to up-regulation of P- and F1C-fimbriae, whereas the PAC-depleted extract had no influence on gene expression. V.m. and V.m. extract≠PAC did not influence biofilm and curli formation in UPEC strains NU14 and 2980. These data lead to the conclusion that also proanthocyanidin-free cranberry extracts exert antiadhesive activity by interaction with mannose-sensitive type 1 fimbriae of UPEC." @default.
• W2415507798 created "2016-06-24" @default.
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• W2415507798 date "2015-09-29" @default.
• W2415507798 modified "2023-10-05" @default.
• W2415507798 title "In Vivo Consumption of Cranberry Exerts ex Vivo Antiadhesive Activity against <i>FimH</i>-Dominated Uropathogenic <i>Escherichia coli</i>: A Combined in Vivo, ex Vivo, and in Vitro Study of an Extract from <i>Vaccinium macrocarpon</i>" @default.
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• W2415507798 doi "https://doi.org/10.1021/acs.jafc.5b03030" @default.
• W2415507798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26330108" @default.
• W2415507798 hasPublicationYear "2015" @default.
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