FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415510977> ?p ?o ?g. }

• W2415510977 endingPage "6774" @default.
• W2415510977 startingPage "6766" @default.
• W2415510977 abstract "Recent advances in nanotechnology bring to the forefront a new class of extrinsic constraints for remodeling lipid bilayers. In this next-generation technology, membranes are supported over nanoporous substrates. The nanometer-sized pores in the substrate are too small for bilayers to follow the substrate topology; consequently, the bilayers hang over the pores. Experiments demonstrate that nanoporous substrates remodel lipid bilayers differently from continuous substrates. The underlying molecular mechanisms, however, remain largely undetermined. Here we use molecular dynamics (MD) simulations to probe the effects of silica-type hydroxylation and charge densities on adsorbed palmitoyl-oleoylphosphatidylcholine (POPC) bilayers. We find that a 50% porous substrate decorated with a surface density of 4.6 hydroxyls/nm2 adsorbs a POPC bilayer at a distance of 4.5 Å, a result consistent with neutron reflectivity experiments conducted on topologically similar silica constructs under highly acidic conditions. Although such an adsorption distance suggests that the interaction between the bilayer and the substrate will be buffered by water molecules, we find that the substrate does interact directly with the bilayer. The substrate modifies several properties of the bilayer—it dampens transverse lipid fluctuations, reduces lipid diffusion rates, and modifies transverse charge densities significantly. Additionally, it affects lipid properties differently in the two leaflets. Compared to substrates functionalized with sparser surface hydroxylation densities, this substrate adheres to bilayers at smaller distances and also remodels POPC more extensively, suggesting a direct correspondence between substrate hydrophilicity and membrane properties. A partial deprotonation of surface hydroxyls, as expected of a silica substrate under mildly acidic conditions, however, produces an inverse effect: it increases the substrate–bilayer distance, which we attribute to the formation of an electric double layer over the negatively charged substrate, and restores, at least partially, leaflet asymmetry and headgroup orientations. Overall, this study highlights the intrinsic complexity of lipid–substrate interactions and suggests the prospect of making two surface attributes—dipole densities and charge densities—work antagonistically toward remodeling lipid bilayer properties." @default.
• W2415510977 created "2016-06-24" @default.
• W2415510977 creator A5004495836 @default.
• W2415510977 creator A5005169856 @default.
• W2415510977 creator A5024658204 @default.
• W2415510977 creator A5027761662 @default.
• W2415510977 creator A5058856579 @default.
• W2415510977 date "2016-06-21" @default.
• W2415510977 modified "2023-09-25" @default.
• W2415510977 title "POPC Bilayers Supported on Nanoporous Substrates: Specific Effects of Silica-Type Surface Hydroxylation and Charge Density" @default.
• W2415510977 cites W1963969470 @default.
• W2415510977 cites W1966078827 @default.
• W2415510977 cites W1967158715 @default.
• W2415510977 cites W1968298368 @default.
• W2415510977 cites W1968620218 @default.
• W2415510977 cites W1975027906 @default.
• W2415510977 cites W1986709960 @default.
• W2415510977 cites W1991261158 @default.
• W2415510977 cites W1991655565 @default.
• W2415510977 cites W1991794210 @default.
• W2415510977 cites W1992079264 @default.
• W2415510977 cites W1992451923 @default.
• W2415510977 cites W1998313054 @default.
• W2415510977 cites W1998634209 @default.
• W2415510977 cites W1998781337 @default.
• W2415510977 cites W2001443424 @default.
• W2415510977 cites W2002827932 @default.
• W2415510977 cites W2007112416 @default.
• W2415510977 cites W2014503023 @default.
• W2415510977 cites W2020785009 @default.
• W2415510977 cites W2023271753 @default.
• W2415510977 cites W2024134244 @default.
• W2415510977 cites W2029015814 @default.
• W2415510977 cites W2029332412 @default.
• W2415510977 cites W2033906450 @default.
• W2415510977 cites W2034430125 @default.
• W2415510977 cites W2035012908 @default.
• W2415510977 cites W2036442531 @default.
• W2415510977 cites W2039200967 @default.
• W2415510977 cites W2041638382 @default.
• W2415510977 cites W2042863472 @default.
• W2415510977 cites W2045696929 @default.
• W2415510977 cites W2049475242 @default.
• W2415510977 cites W2052165970 @default.
• W2415510977 cites W2052959333 @default.
• W2415510977 cites W2053840501 @default.
• W2415510977 cites W2055701049 @default.
• W2415510977 cites W2059013803 @default.
• W2415510977 cites W2067174909 @default.
• W2415510977 cites W2067967441 @default.
• W2415510977 cites W2081693079 @default.
• W2415510977 cites W2083683885 @default.
• W2415510977 cites W2085767196 @default.
• W2415510977 cites W2086293983 @default.
• W2415510977 cites W2089792637 @default.
• W2415510977 cites W2090167009 @default.
• W2415510977 cites W2091119718 @default.
• W2415510977 cites W2094497870 @default.
• W2415510977 cites W2103945336 @default.
• W2415510977 cites W2118596974 @default.
• W2415510977 cites W2124138679 @default.
• W2415510977 cites W2125872855 @default.
• W2415510977 cites W2126901672 @default.
• W2415510977 cites W2132480710 @default.
• W2415510977 cites W2134639427 @default.
• W2415510977 cites W2136558879 @default.
• W2415510977 cites W2141761648 @default.
• W2415510977 cites W2143981217 @default.
• W2415510977 cites W2160679445 @default.
• W2415510977 cites W2162504167 @default.
• W2415510977 cites W2164565944 @default.
• W2415510977 cites W2167956058 @default.
• W2415510977 cites W2321129758 @default.
• W2415510977 cites W2322574668 @default.
• W2415510977 cites W2334153677 @default.
• W2415510977 cites W2992305306 @default.
• W2415510977 cites W3104062667 @default.
• W2415510977 doi "https://doi.org/10.1021/acs.langmuir.6b01155" @default.
• W2415510977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27283467" @default.
• W2415510977 hasPublicationYear "2016" @default.
• W2415510977 type Work @default.
• W2415510977 sameAs 2415510977 @default.
• W2415510977 citedByCount "12" @default.
• W2415510977 countsByYear W24155109772017 @default.
• W2415510977 countsByYear W24155109772018 @default.
• W2415510977 countsByYear W24155109772019 @default.
• W2415510977 countsByYear W24155109772020 @default.
• W2415510977 countsByYear W24155109772021 @default.
• W2415510977 crossrefType "journal-article" @default.
• W2415510977 hasAuthorship W2415510977A5004495836 @default.
• W2415510977 hasAuthorship W2415510977A5005169856 @default.
• W2415510977 hasAuthorship W2415510977A5024658204 @default.
• W2415510977 hasAuthorship W2415510977A5027761662 @default.
• W2415510977 hasAuthorship W2415510977A5058856579 @default.
• W2415510977 hasConcept C111368507 @default.
• W2415510977 hasConcept C127313418 @default.
• W2415510977 hasConcept C127413603 @default.
• W2415510977 hasConcept C150394285 @default.

• next