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- W2415511556 abstract "Acute myeloid leukemia (AML) accounts for approximately 20% of childhood leukemia, yet is responsible for a majority of the deaths from leukemia. Children present with a wide range of signs and symptoms, ranging from anemia to life-threatening coagulopathy, complications from tumor lysis syndrome or leukemic infiltration. Patients with AML are at an increased risk of infection and should receive prophylactic antimicrobials. Cytarabine, daunorubicin, and etoposide remain the backbone of AML therapy. Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin (FLAG-IDA) are utilized for relapsed/refractory AML. Hematopoietic stem cell transplantation is recommended for high-risk and relapsed patients. Therapies targeting novel molecular and cytogenetic markers are under investigation. Acute promyelocytic leukemia, a unique subtype of AML, is treated with all-trans retinoic acid and arsenic trioxide, with very good response. Myeloid leukemia in Down syndrome is another unique subtype of AML; patients typically have a GATA1 mutation and have an excellent response to reduced intensity regimens. Methods with increased sensitivities are being utilized for the detection of occult disease below the level of morphologic detection, referred to as minimal residual disease (MRD). Treatment protocols utilize MRD to assess response to therapy and guide future therapy." @default.
- W2415511556 created "2016-06-24" @default.
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- W2415511556 date "2016-01-01" @default.
- W2415511556 modified "2023-10-17" @default.
- W2415511556 title "Acute Myeloid Leukemia" @default.
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- W2415511556 doi "https://doi.org/10.1016/b978-0-12-801368-7.00019-3" @default.
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