FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415513304> ?p ?o ?g. }

• W2415513304 abstract "Anti-citrullinated-peptide antibodies (ACPA) have been detected in individuals with developing rheumatoid arthritis (RA) before the onset of symptom, with an initially limited spectrum of reactivities that gradually broadens. The aim was to analyze the evolution of ACPA response pre-dating symptom onset, using four selected citrullinated exogenous and endogenous antigens. A cohort of 521 individuals sampled before symptoms of RA appeared and 272 population controls were identified from the Biobank of Northern Sweden; 241 samples from patients with early RA were also collected. ACPA were detected by ELISA on viral citrullinated peptides (VCP) derived from Epstein-Barr-virus nuclear antigen (EBNA)1 and EBNA2 (VCP1 and VCP2) and histone-4-derived citrullinated peptides (HCP1 and HCP2). In pre-symptomatic individuals vs. patients with early RA, anti-VCP1 antibodies were detected in 10.4 % vs. 36.1 %, anti-VCP2 in 17.1 % vs. 52.3 %, anti-HCP1 in 10.2 % vs. 37.3 %, and anti-HCP2 in 16.3 % vs. 48.5 %, respectively. Anti-VCP and anti-HCP concentrations were significantly increased in pre-symptomatic individuals vs. controls (p < 0.001) and were increased approaching symptom onset. Anti-VCP and anti-HCP appeared simultaneously (median (IQR) 5.3 (6) years before symptom onset) and in combination yielded a high-risk ratio for disease development (OR = 8.0–18.9). Anti-VCP2 and anti-HCP2 antibodies were associated with HLA-DRB1*0401 in pre-symptomatic individuals. Three peptidylarginine deiminase (PAD)I3/PADI4 single nucleotide polymorphisms (SNPs) were significantly associated with anti-HCP1. Anti-VCP and anti-HCP antibodies pre-date symptom onset and predict disease development, but no hierarchy of citrullinated epitopes can be identified. These results suggest that no inciting citrullinated antigen so far described is common to all patients with RA. The association between PADI3/PADI4 polymorphism and anti-HCP1 antibodies suggests a novel link between deimination and production of ACPA." @default.
• W2415513304 created "2016-06-24" @default.
• W2415513304 creator A5005179796 @default.
• W2415513304 creator A5018558637 @default.
• W2415513304 creator A5024513740 @default.
• W2415513304 creator A5024559961 @default.
• W2415513304 creator A5062556190 @default.
• W2415513304 creator A5077474262 @default.
• W2415513304 creator A5084836838 @default.
• W2415513304 creator A5087811228 @default.
• W2415513304 date "2016-06-03" @default.
• W2415513304 modified "2023-10-10" @default.
• W2415513304 title "Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis" @default.
• W2415513304 cites W1532952219 @default.
• W2415513304 cites W1566049124 @default.
• W2415513304 cites W1901640178 @default.
• W2415513304 cites W1913865297 @default.
• W2415513304 cites W1988789861 @default.
• W2415513304 cites W1991965941 @default.
• W2415513304 cites W2005250923 @default.
• W2415513304 cites W2006560462 @default.
• W2415513304 cites W2016382347 @default.
• W2415513304 cites W2024988150 @default.
• W2415513304 cites W2048669633 @default.
• W2415513304 cites W2087064951 @default.
• W2415513304 cites W2087540611 @default.
• W2415513304 cites W2088329414 @default.
• W2415513304 cites W2088961262 @default.
• W2415513304 cites W2096965824 @default.
• W2415513304 cites W2096966555 @default.
• W2415513304 cites W2100068629 @default.
• W2415513304 cites W2104669609 @default.
• W2415513304 cites W2107005433 @default.
• W2415513304 cites W2111561164 @default.
• W2415513304 cites W2129827067 @default.
• W2415513304 cites W2130357582 @default.
• W2415513304 cites W2132576596 @default.
• W2415513304 cites W2141521401 @default.
• W2415513304 cites W2141522272 @default.
• W2415513304 cites W2144142375 @default.
• W2415513304 cites W2144712056 @default.
• W2415513304 cites W2152348310 @default.
• W2415513304 cites W2152818840 @default.
• W2415513304 cites W2161222221 @default.
• W2415513304 cites W2161633633 @default.
• W2415513304 cites W2195959595 @default.
• W2415513304 cites W4231236597 @default.
• W2415513304 doi "https://doi.org/10.1186/s13075-016-1031-0" @default.
• W2415513304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4891920" @default.
• W2415513304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27255888" @default.
• W2415513304 hasPublicationYear "2016" @default.
• W2415513304 type Work @default.
• W2415513304 sameAs 2415513304 @default.
• W2415513304 citedByCount "43" @default.
• W2415513304 countsByYear W24155133042016 @default.
• W2415513304 countsByYear W24155133042017 @default.
• W2415513304 countsByYear W24155133042018 @default.
• W2415513304 countsByYear W24155133042019 @default.
• W2415513304 countsByYear W24155133042020 @default.
• W2415513304 countsByYear W24155133042021 @default.
• W2415513304 countsByYear W24155133042022 @default.
• W2415513304 countsByYear W24155133042023 @default.
• W2415513304 crossrefType "journal-article" @default.
• W2415513304 hasAuthorship W2415513304A5005179796 @default.
• W2415513304 hasAuthorship W2415513304A5018558637 @default.
• W2415513304 hasAuthorship W2415513304A5024513740 @default.
• W2415513304 hasAuthorship W2415513304A5024559961 @default.
• W2415513304 hasAuthorship W2415513304A5062556190 @default.
• W2415513304 hasAuthorship W2415513304A5077474262 @default.
• W2415513304 hasAuthorship W2415513304A5084836838 @default.
• W2415513304 hasAuthorship W2415513304A5087811228 @default.
• W2415513304 hasBestOaLocation W24155133041 @default.
• W2415513304 hasConcept C126322002 @default.
• W2415513304 hasConcept C147483822 @default.
• W2415513304 hasConcept C159654299 @default.
• W2415513304 hasConcept C163764329 @default.
• W2415513304 hasConcept C198451711 @default.
• W2415513304 hasConcept C203014093 @default.
• W2415513304 hasConcept C2777077863 @default.
• W2415513304 hasConcept C2777468819 @default.
• W2415513304 hasConcept C2777575956 @default.
• W2415513304 hasConcept C2779129087 @default.
• W2415513304 hasConcept C2908647359 @default.
• W2415513304 hasConcept C48632299 @default.
• W2415513304 hasConcept C515207424 @default.
• W2415513304 hasConcept C54355233 @default.
• W2415513304 hasConcept C71924100 @default.
• W2415513304 hasConcept C86803240 @default.
• W2415513304 hasConcept C90924648 @default.
• W2415513304 hasConcept C99454951 @default.
• W2415513304 hasConceptScore W2415513304C126322002 @default.
• W2415513304 hasConceptScore W2415513304C147483822 @default.
• W2415513304 hasConceptScore W2415513304C159654299 @default.
• W2415513304 hasConceptScore W2415513304C163764329 @default.
• W2415513304 hasConceptScore W2415513304C198451711 @default.
• W2415513304 hasConceptScore W2415513304C203014093 @default.
• W2415513304 hasConceptScore W2415513304C2777077863 @default.
• W2415513304 hasConceptScore W2415513304C2777468819 @default.
• W2415513304 hasConceptScore W2415513304C2777575956 @default.
• W2415513304 hasConceptScore W2415513304C2779129087 @default.

• next