Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415516056> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2415516056 endingPage "45" @default.
- W2415516056 startingPage "335" @default.
- W2415516056 abstract "Effects of Ca++-antagonists on the conduction delay observed in the ischemic myocardium were studied in open-chest anesthetized dogs. Complete occlusion of the left anterior descending coronary artery (LAD) for 5 or 10 min under a constant atrial pacing produced conduction delay in the ischemic zone. Lidocaine which was administered prior to the LD occlusion increased the conduction delay, whereas Ca++-antagonists, verapamil and diltiazem, reduced the ischemia-induced conduction delay. To determine whether the coronary vasodilating action of these Ca++-antagonists can play a role in reducing the ischemia-induced conduction delay by means of increasing the collateral blood flow, the effects of these Ca++-antagonists were compared with those of other coronary vasodilating drugs on the coronary circulation and the ischemia-induced conduction delay. Administration of verapamil, diltiazem, nifedipine, nitroglycerin+phenylephrine and dipyridamole increased both the blood flow of the left circumflex coronary artery and the regional myocardial blood flow at LAD area, whereas nitroglycerin alone decreased and isosorbide dinitrate hardly affected them. Nevertheless, only drugs possessing a slow channel blocking action, i.e. verapamil, diltiazem and a large dose of nifedipine, improved the conduction delay. Effects of verapamil on the conduction delay and potassium efflux induced by global myocardial ischemia were evaluated in isolated Langendorff-perfused rabbit hearts. Perfusion with a modified Tyrode solution containing 10-1000 ng/ml of verapamil prior to 7 min of global ischemia significantly prevented the intramyocardial conduction delay. However, the potassium efflux into the coronary effluents during ischemia and 1 min after reperfusion was not significantly reduced by verapamil. These results indicate that the favorable effect of Ca++-antagonists on the ischemia-induced conduction delay is not associated with the improvement of coronary circulation or the reduction of potassium efflux from the ischemic myocardium." @default.
- W2415516056 created "2016-06-24" @default.
- W2415516056 creator A5027768055 @default.
- W2415516056 date "1981-05-01" @default.
- W2415516056 modified "2023-09-23" @default.
- W2415516056 title "[Underlying mechanism of favorable effect of Ca++-antagonists on conduction delay observed in ischemic myocardium (author's transl)]." @default.
- W2415516056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7319455" @default.
- W2415516056 hasPublicationYear "1981" @default.
- W2415516056 type Work @default.
- W2415516056 sameAs 2415516056 @default.
- W2415516056 citedByCount "1" @default.
- W2415516056 crossrefType "journal-article" @default.
- W2415516056 hasAuthorship W2415516056A5027768055 @default.
- W2415516056 hasConcept C120770815 @default.
- W2415516056 hasConcept C126322002 @default.
- W2415516056 hasConcept C146957229 @default.
- W2415516056 hasConcept C158846371 @default.
- W2415516056 hasConcept C164705383 @default.
- W2415516056 hasConcept C2776157398 @default.
- W2415516056 hasConcept C2776741139 @default.
- W2415516056 hasConcept C2777022698 @default.
- W2415516056 hasConcept C2779066535 @default.
- W2415516056 hasConcept C2780393670 @default.
- W2415516056 hasConcept C2909076160 @default.
- W2415516056 hasConcept C42219234 @default.
- W2415516056 hasConcept C519063684 @default.
- W2415516056 hasConcept C541997718 @default.
- W2415516056 hasConcept C71924100 @default.
- W2415516056 hasConceptScore W2415516056C120770815 @default.
- W2415516056 hasConceptScore W2415516056C126322002 @default.
- W2415516056 hasConceptScore W2415516056C146957229 @default.
- W2415516056 hasConceptScore W2415516056C158846371 @default.
- W2415516056 hasConceptScore W2415516056C164705383 @default.
- W2415516056 hasConceptScore W2415516056C2776157398 @default.
- W2415516056 hasConceptScore W2415516056C2776741139 @default.
- W2415516056 hasConceptScore W2415516056C2777022698 @default.
- W2415516056 hasConceptScore W2415516056C2779066535 @default.
- W2415516056 hasConceptScore W2415516056C2780393670 @default.
- W2415516056 hasConceptScore W2415516056C2909076160 @default.
- W2415516056 hasConceptScore W2415516056C42219234 @default.
- W2415516056 hasConceptScore W2415516056C519063684 @default.
- W2415516056 hasConceptScore W2415516056C541997718 @default.
- W2415516056 hasConceptScore W2415516056C71924100 @default.
- W2415516056 hasIssue "3" @default.
- W2415516056 hasLocation W24155160561 @default.
- W2415516056 hasOpenAccess W2415516056 @default.
- W2415516056 hasPrimaryLocation W24155160561 @default.
- W2415516056 hasRelatedWork W1966565494 @default.
- W2415516056 hasRelatedWork W1967780571 @default.
- W2415516056 hasRelatedWork W2051413992 @default.
- W2415516056 hasRelatedWork W2076103635 @default.
- W2415516056 hasRelatedWork W2095154387 @default.
- W2415516056 hasRelatedWork W2171101647 @default.
- W2415516056 hasRelatedWork W2402164523 @default.
- W2415516056 hasRelatedWork W2412014386 @default.
- W2415516056 hasRelatedWork W2415516056 @default.
- W2415516056 hasRelatedWork W2463472921 @default.
- W2415516056 hasVolume "56" @default.
- W2415516056 isParatext "false" @default.
- W2415516056 isRetracted "false" @default.
- W2415516056 magId "2415516056" @default.
- W2415516056 workType "article" @default.