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• W2415580910 abstract "No AccessJournal of Urology1 Dec 1991The Frequency and Morbidity of Local Tumor Recurrence after Definitive Radiotherapy for Stage C Prostate Cancer Madelyn Holzman, C. Eugene Carlton, and Peter T. Scardino Madelyn HolzmanMadelyn Holzman More articles by this author , C. Eugene CarltonC. Eugene Carlton More articles by this author , and Peter T. ScardinoPeter T. Scardino More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38171-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Radiotherapy is reported to provide good control of locally advanced prostate cancer. However, few long-term studies have assessed the morbidity related to local tumor recurrence in patients treated with radiotherapy alone (without hormonal manipulation). To determine the frequency and severity of morbidity related to local recurrence we reviewed the course of all patients with clinical stage C prostate cancer treated at our institution between 1966 and 1979 with bilateral pelvic lymph node dissection, radioactive gold seed implantation and external beam irradiation therapy to the prostate. Of the 121 patients 60% died and the 40% still alive at the time of review were followed for a mean of 8.1 years (range 3.3 to 14.8 years). Over-all, 64 patients (53%) had local recurrence, which was defined as a clinical event causing signs or symptoms and was proved by biopsy. On an actuarial basis the risk of local recurrence was 43 ± 10% (mean ± 2 standard errors) at 5 years and 74 ± 11% at 10 years. Any symptomatic episode requiring active intervention or causing morbidity was denoted an adverse event. There were 162 adverse events among the 73 patients (2.2 adverse events per patient): 69% of these were severe (requiring surgical intervention) and 55% were chronic (more than 3 months in duration). The most common cause of an adverse event was bladder outlet obstruction requiring transurethral resection of the prostate (44 patients); 16 patients (13%) became incontinent. Hydronephrosis developed in 24 patients (20%). Local recurrence after definitive radiotherapy for our patients with stage C prostate cancer was common and was associated with serious morbidity, frequently requiring surgical intervention. Radiotherapy alone may not be sufficient to provide long-term local control of stage C prostate cancer. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByGotto G, Yunis L, Vora K, Eastham J, Scardino P and Rabbani F (2018) Impact of Prior Prostate Radiation on Complications After Radical ProstatectomyJournal of Urology, VOL. 184, NO. 1, (136-142), Online publication date: 1-Jul-2010.Ward J (2018) Editorial CommentJournal of Urology, VOL. 176, NO. 5, (2031-2032), Online publication date: 1-Nov-2006.KOLLMEIER M, STOCK R, CESARETTI J and STONE N (2018) URINARY MORBIDITY AND INCONTINENCE FOLLOWING TRANSURETHRAL RESECTION OF THE PROSTATE AFTER BRACHYTHERAPYJournal of Urology, VOL. 173, NO. 3, (808-812), Online publication date: 1-Mar-2005.STEPHENSON A, SCARDINO P, BIANCO F, DiBLASIO C, FEARN P and EASTHAM J (2018) MORBIDITY AND FUNCTIONAL OUTCOMES OF SALVAGE RADICAL PROSTATECTOMY FOR LOCALLY RECURRENT PROSTATE CANCER AFTER RADIATION THERAPYJournal of Urology, VOL. 172, NO. 6 Part 1, (2239-2243), Online publication date: 1-Dec-2004.STEINER M and GINGRICH J (2018) GENE THERAPY FOR PROSTATE CANCER: WHERE ARE WE NOW?Journal of Urology, VOL. 164, NO. 4, (1121-1136), Online publication date: 1-Oct-2000.Long J, Fallick M, LaRock D and Rand W (2018) PRELIMINARY OUTCOMES FOLLOWING CRYOSURGICAL ABLATION OF THE PROSTATE IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CARCINOMAJournal of Urology, VOL. 159, NO. 2, (477-484), Online publication date: 1-Feb-1998.Lim A, Brandon A, Fiedler J, Brickman A, Boyer C, Raub W and Soloway M (2018) Quality of Life: Radical Prostatectomy Versus Radiation Therapy for Prostate CancerJournal of Urology, VOL. 154, NO. 4, (1420-1425), Online publication date: 1-Oct-1995.Lerner S, Blute M and Zincke H (2018) Extended Experience With Radical Prostatectomy for Clinical Stage T3 Prostate Cancer: Outcome and Contemporary MorbidityJournal of Urology, VOL. 154, NO. 4, (1447-1452), Online publication date: 1-Oct-1995.Stamey T, Ferrari M and Schmid H (2018) In Reply: Re The Value of Serial Prostate Specific Antigen Determinations 5 Years After RadiotherapyJournal of Urology, VOL. 153, NO. 6, (1954-1954), Online publication date: 1-Jun-1995.Rogers E, Ohori M, Kassabian V, Wheeler T and Scardino P (2018) Salvage Radical Prostatectomy: Outcome Measured by Serum Prostate Specific Antigen LevelsJournal of Urology, VOL. 153, NO. 1, (104-110), Online publication date: 1-Jan-1995. (2018) Reply by AuthorsJournal of Urology, VOL. 152, NO. 5 Part 1, (1565-1566), Online publication date: 1-Nov-1994.Stamey T, Ferrari M and Schmid H (2018) The Value of Serial Prostate Specific Antigen Determinations 5 Years after Radiotherapy: Steeply Increasing Values Characterize 80% of PatientsJournal of Urology, VOL. 150, NO. 6, (1856-1859), Online publication date: 1-Dec-1993. Volume 146Issue 6December 1991Page: 1578-1582 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordscarcinomaradiotherapyprostatic neoplasmsMetricsAuthor Information Madelyn Holzman More articles by this author C. Eugene Carlton More articles by this author Peter T. Scardino More articles by this author Expand All Advertisement Loading ..." @default.
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