FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415607102> ?p ?o ?g. }

• W2415607102 endingPage "e92" @default.
• W2415607102 startingPage "e87" @default.
• W2415607102 abstract "Cu-ATSM is a very promising PET radiopharmaceutical for tumor imaging of hypoxia. One of the advantages of this compound compared with other hypoxia-avid tracers is the high tumor-to-background signal offered, which guaranties facilitated tumor delineation. This study analyzes optimal semiquantitative and quantitative parameters obtained by Cu-ATSM PET/CT in the same cohort of patients with special focus on their correlation to disease outcome.A prospective recruitment of 18 consecutive patients (M:F, 13:5; mean age, 60.7 years) with locally advanced non-small cell lung cancer (n = 7) or head and neck cancer (HNC) was performed. Each participant received 105 to 500 MBq of tracer according to body size and was scanned in a 3-dimensional mode PET/CT 60 minutes after tracer injection. PET images were reconstructed and visualized on a GE Advanced 4.6 workstation for the definition of semiquantitative and quantitative parameters: SUVmax, SUVratio-to-muscle, hypoxic tumor volume (HTV), and hypoxic burden (HB = HTV × SUVmean). These data were subsequently correlated to disease outcome, expressed in terms of progression-free survival calculated on a follow-up period with a median of 14.6 months.All patients showed a moderately to highly increased uptake of Cu-ATSM in tumor lesions, with a mean SUVmax of 5.2 (range, 1.9-8.3) and mean SUVratio of 4.4 (range, 1.6-6.8). In addition, a broad range of HTV and HB was defined as mean values of 99.3 cm (range, 2.5-453.7 cm) and 301 (4.2-1134), respectively. Receiver operating characteristic analysis identified as reference cutoffs with respect to disease outcome with the following values: SUVmax >2.5 (AUC, 0.57; sensitivity, 88.9%; specificity, 50%), SUVratio ≤4.4 (AUC, 0.60; sensitivity, 50; specificity, 83.3%), HTV >160.7 cm (AUC, 0.61; sensitivity, 55.6%; specificity, 75%), and HB >160.7 (AUC, 0.67; sensitivity, 58.3%; specificity, 83.3%). In our cohort, HB showed a statistically significant difference in terms of mean values on the analysis of variance test with respect to disease progression (P = 0.04). On univariate analysis, Cox regression confirmed these findings and showed a significant correlation to progression-free survival for HB (P = 0.05) and HTV (P = 0.02).In our cohort, the definition of optimal semiquantitative and quantitative parameters on Cu-ATSM PET/CT seems feasible and in line with previously published data. However, when considering the prognostic role with respect to disease outcome, the more robust parameters are represented by HTV and HB." @default.
• W2415607102 created "2016-06-24" @default.
• W2415607102 creator A5010421937 @default.
• W2415607102 creator A5022316813 @default.
• W2415607102 creator A5023111355 @default.
• W2415607102 creator A5035448176 @default.
• W2415607102 creator A5035543933 @default.
• W2415607102 creator A5040282661 @default.
• W2415607102 creator A5056293658 @default.
• W2415607102 creator A5059462029 @default.
• W2415607102 creator A5060396380 @default.
• W2415607102 creator A5070750504 @default.
• W2415607102 creator A5073260574 @default.
• W2415607102 creator A5085427107 @default.
• W2415607102 date "2016-02-01" @default.
• W2415607102 modified "2023-09-27" @default.
• W2415607102 title "Prognostic Evaluation of Disease Outcome in Solid Tumors Investigated With 64Cu-ATSM PET/CT" @default.
• W2415607102 cites W1981755022 @default.
• W2415607102 cites W1982845574 @default.
• W2415607102 cites W1983489444 @default.
• W2415607102 cites W1995287452 @default.
• W2415607102 cites W2008283713 @default.
• W2415607102 cites W2015438279 @default.
• W2415607102 cites W2016550302 @default.
• W2415607102 cites W2023448884 @default.
• W2415607102 cites W2030892741 @default.
• W2415607102 cites W2044245267 @default.
• W2415607102 cites W2049843142 @default.
• W2415607102 cites W2057343401 @default.
• W2415607102 cites W2073132333 @default.
• W2415607102 cites W2086050544 @default.
• W2415607102 cites W2111176717 @default.
• W2415607102 cites W2157607856 @default.
• W2415607102 cites W2158636665 @default.
• W2415607102 cites W2166071433 @default.
• W2415607102 cites W2322223636 @default.
• W2415607102 doi "https://doi.org/10.1097/rlu.0000000000001017" @default.
• W2415607102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26447388" @default.
• W2415607102 hasPublicationYear "2016" @default.
• W2415607102 type Work @default.
• W2415607102 sameAs 2415607102 @default.
• W2415607102 citedByCount "31" @default.
• W2415607102 countsByYear W24156071022016 @default.
• W2415607102 countsByYear W24156071022017 @default.
• W2415607102 countsByYear W24156071022018 @default.
• W2415607102 countsByYear W24156071022019 @default.
• W2415607102 countsByYear W24156071022020 @default.
• W2415607102 countsByYear W24156071022021 @default.
• W2415607102 countsByYear W24156071022022 @default.
• W2415607102 crossrefType "journal-article" @default.
• W2415607102 hasAuthorship W2415607102A5010421937 @default.
• W2415607102 hasAuthorship W2415607102A5022316813 @default.
• W2415607102 hasAuthorship W2415607102A5023111355 @default.
• W2415607102 hasAuthorship W2415607102A5035448176 @default.
• W2415607102 hasAuthorship W2415607102A5035543933 @default.
• W2415607102 hasAuthorship W2415607102A5040282661 @default.
• W2415607102 hasAuthorship W2415607102A5056293658 @default.
• W2415607102 hasAuthorship W2415607102A5059462029 @default.
• W2415607102 hasAuthorship W2415607102A5060396380 @default.
• W2415607102 hasAuthorship W2415607102A5070750504 @default.
• W2415607102 hasAuthorship W2415607102A5073260574 @default.
• W2415607102 hasAuthorship W2415607102A5085427107 @default.
• W2415607102 hasConcept C126322002 @default.
• W2415607102 hasConcept C126838900 @default.
• W2415607102 hasConcept C188816634 @default.
• W2415607102 hasConcept C2775842073 @default.
• W2415607102 hasConcept C2776256026 @default.
• W2415607102 hasConcept C2779081379 @default.
• W2415607102 hasConcept C2989005 @default.
• W2415607102 hasConcept C509974204 @default.
• W2415607102 hasConcept C71924100 @default.
• W2415607102 hasConcept C72563966 @default.
• W2415607102 hasConceptScore W2415607102C126322002 @default.
• W2415607102 hasConceptScore W2415607102C126838900 @default.
• W2415607102 hasConceptScore W2415607102C188816634 @default.
• W2415607102 hasConceptScore W2415607102C2775842073 @default.
• W2415607102 hasConceptScore W2415607102C2776256026 @default.
• W2415607102 hasConceptScore W2415607102C2779081379 @default.
• W2415607102 hasConceptScore W2415607102C2989005 @default.
• W2415607102 hasConceptScore W2415607102C509974204 @default.
• W2415607102 hasConceptScore W2415607102C71924100 @default.
• W2415607102 hasConceptScore W2415607102C72563966 @default.
• W2415607102 hasIssue "2" @default.
• W2415607102 hasLocation W24156071021 @default.
• W2415607102 hasLocation W24156071022 @default.
• W2415607102 hasOpenAccess W2415607102 @default.
• W2415607102 hasPrimaryLocation W24156071021 @default.
• W2415607102 hasRelatedWork W1967687873 @default.
• W2415607102 hasRelatedWork W2002557350 @default.
• W2415607102 hasRelatedWork W2013568115 @default.
• W2415607102 hasRelatedWork W2074829765 @default.
• W2415607102 hasRelatedWork W2093988815 @default.
• W2415607102 hasRelatedWork W2102954422 @default.
• W2415607102 hasRelatedWork W2746638370 @default.
• W2415607102 hasRelatedWork W2789946190 @default.
• W2415607102 hasRelatedWork W2793642532 @default.
• W2415607102 hasRelatedWork W4297666546 @default.
• W2415607102 hasVolume "41" @default.

• next