FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415612875> ?p ?o ?g. }

• W2415612875 endingPage "12321" @default.
• W2415612875 startingPage "12310" @default.
• W2415612875 abstract "Parkinson disease (PD) is a neurodegenerative disorder with loss of dopaminergic neurons of the brain, which results in insufficient synthesis and action of dopamine. Metastasis-associated protein 1 (MTA1) is an upstream modulator of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, and hence MTA1 plays a significant role in PD pathogenesis. To impart functional and clinical significance to MTA1, we analyzed MTA1 and TH levels in the substantia nigra region of a large cohort of human brain tissue samples by Western blotting, quantitative PCR, and immunohistochemistry. Our results showed that MTA1 and TH levels were significantly down-regulated in PD samples as compared with normal brain tissue. Correspondingly, immunohistochemistry analysis for MTA1 in substantia nigra sections revealed that 74.1% of the samples had a staining intensity of <6 in the PD samples as compared with controls, 25.9%, with an odds ratio of 8.54. Because of the clinical importance of MTA1 established in PD, we looked at agents to modulate MTA1 expression in neuronal cells, and granulocyte colony-stimulating factor (G-CSF) was chosen, due to its clinically proven neurogenic effects. Treatment of the human neuronal cell line KELLY and acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model with G-CSF showed significant induction of MTA1 and TH with rescue of phenotype in the mouse model. Interestingly, the observed induction of TH was compromised on silencing of MTA1. The underlying molecular mechanism of MTA1 induction by G-CSF was proved to be through induction of c-Fos and its recruitment to the MTA1 promoter." @default.
• W2415612875 created "2016-06-24" @default.
• W2415612875 creator A5001207850 @default.
• W2415612875 creator A5005012399 @default.
• W2415612875 creator A5024025087 @default.
• W2415612875 creator A5027403517 @default.
• W2415612875 creator A5037944535 @default.
• W2415612875 creator A5038499791 @default.
• W2415612875 creator A5045569479 @default.
• W2415612875 creator A5053987450 @default.
• W2415612875 creator A5060883814 @default.
• W2415612875 creator A5065120976 @default.
• W2415612875 creator A5068176154 @default.
• W2415612875 creator A5069640338 @default.
• W2415612875 date "2016-06-01" @default.
• W2415612875 modified "2023-10-10" @default.
• W2415612875 title "Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor" @default.
• W2415612875 cites W1520362442 @default.
• W2415612875 cites W1528334073 @default.
• W2415612875 cites W1541003458 @default.
• W2415612875 cites W1946309633 @default.
• W2415612875 cites W1969735755 @default.
• W2415612875 cites W1974171398 @default.
• W2415612875 cites W1986403211 @default.
• W2415612875 cites W1986458904 @default.
• W2415612875 cites W1998620230 @default.
• W2415612875 cites W2002728772 @default.
• W2415612875 cites W2005917373 @default.
• W2415612875 cites W2009449451 @default.
• W2415612875 cites W2009563843 @default.
• W2415612875 cites W2010737609 @default.
• W2415612875 cites W2028767525 @default.
• W2415612875 cites W2036537291 @default.
• W2415612875 cites W2037661527 @default.
• W2415612875 cites W2038924084 @default.
• W2415612875 cites W2047209584 @default.
• W2415612875 cites W2053173069 @default.
• W2415612875 cites W2054087453 @default.
• W2415612875 cites W2072251798 @default.
• W2415612875 cites W2072519067 @default.
• W2415612875 cites W2074142625 @default.
• W2415612875 cites W2079983647 @default.
• W2415612875 cites W2081845158 @default.
• W2415612875 cites W2084138606 @default.
• W2415612875 cites W2089668713 @default.
• W2415612875 cites W2093447454 @default.
• W2415612875 cites W2100632503 @default.
• W2415612875 cites W2106628955 @default.
• W2415612875 cites W2107683010 @default.
• W2415612875 cites W2126336008 @default.
• W2415612875 cites W2128108981 @default.
• W2415612875 cites W2141422001 @default.
• W2415612875 cites W2157535407 @default.
• W2415612875 cites W2171593997 @default.
• W2415612875 cites W2171690942 @default.
• W2415612875 cites W2252961857 @default.
• W2415612875 cites W2331848670 @default.
• W2415612875 cites W4234540090 @default.
• W2415612875 cites W2058183475 @default.
• W2415612875 doi "https://doi.org/10.1074/jbc.m115.707224" @default.
• W2415612875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4933278" @default.
• W2415612875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27044752" @default.
• W2415612875 hasPublicationYear "2016" @default.
• W2415612875 type Work @default.
• W2415612875 sameAs 2415612875 @default.
• W2415612875 citedByCount "8" @default.
• W2415612875 countsByYear W24156128752018 @default.
• W2415612875 countsByYear W24156128752019 @default.
• W2415612875 countsByYear W24156128752021 @default.
• W2415612875 countsByYear W24156128752022 @default.
• W2415612875 crossrefType "journal-article" @default.
• W2415612875 hasAuthorship W2415612875A5001207850 @default.
• W2415612875 hasAuthorship W2415612875A5005012399 @default.
• W2415612875 hasAuthorship W2415612875A5024025087 @default.
• W2415612875 hasAuthorship W2415612875A5027403517 @default.
• W2415612875 hasAuthorship W2415612875A5037944535 @default.
• W2415612875 hasAuthorship W2415612875A5038499791 @default.
• W2415612875 hasAuthorship W2415612875A5045569479 @default.
• W2415612875 hasAuthorship W2415612875A5053987450 @default.
• W2415612875 hasAuthorship W2415612875A5060883814 @default.
• W2415612875 hasAuthorship W2415612875A5065120976 @default.
• W2415612875 hasAuthorship W2415612875A5068176154 @default.
• W2415612875 hasAuthorship W2415612875A5069640338 @default.
• W2415612875 hasBestOaLocation W24156128751 @default.
• W2415612875 hasConcept C109159458 @default.
• W2415612875 hasConcept C121332964 @default.
• W2415612875 hasConcept C185592680 @default.
• W2415612875 hasConcept C199360897 @default.
• W2415612875 hasConcept C203014093 @default.
• W2415612875 hasConcept C2776694085 @default.
• W2415612875 hasConcept C2777767877 @default.
• W2415612875 hasConcept C2777983669 @default.
• W2415612875 hasConcept C28328180 @default.
• W2415612875 hasConcept C41008148 @default.
• W2415612875 hasConcept C54355233 @default.
• W2415612875 hasConcept C62520636 @default.
• W2415612875 hasConcept C86803240 @default.
• W2415612875 hasConcept C880424 @default.

• next