Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415616205> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2415616205 endingPage "716" @default.
- W2415616205 startingPage "713" @default.
- W2415616205 abstract "The Southwest Oncology Group undertook a phase II study of teniposide (VM-26) and ifosfamide in refractory adult acute lymphocytic leukemia. The 49 evaluable patients were heavily pretreated; 15 of these had received only one prior induction attempt. Two treatment regimens were used. Eighteen patients received VM-26 (30 mg/m2) on Days 1-5 and ifosfamide (1000 mg/m2) by continuous iv infusion on Days 1-5. When acceptable toxicity was observed, the dose of VM-26 was increased and 30 patients received VM-26 (50 mg/m2) on Days 1-5 in addition to ifosfamide. Complete remission (CR) was observed in two patients who received the lower-dose VM-26 regimen and in six patients who received the higher-dose regimen. Of the eight patients who achieved CR, six were found among the 15 patients who had received only one prior induction therapy. Hematologic toxicity was the major toxic effect observed, with 41 patients (84%) having wbc counts less than 1000/microliter during induction therapy. Nonhematologic toxicity was dose-limiting in seven patients for the following reasons: hematuria (four patients), neurological disturbance (one), and mucositis (two). The combination of VM-26 and ifosfamide is capable of producing CR in refractory acute lymphocytic leukemia in adults with manageable toxicity. Inclusion of the combination in a multidrug consolidation regimen for newly diagnosed patients is an appropriate avenue for further study." @default.
- W2415616205 created "2016-06-24" @default.
- W2415616205 creator A5005996885 @default.
- W2415616205 creator A5033267787 @default.
- W2415616205 creator A5047404272 @default.
- W2415616205 creator A5065968907 @default.
- W2415616205 creator A5071895397 @default.
- W2415616205 creator A5083882513 @default.
- W2415616205 creator A5090228543 @default.
- W2415616205 creator A5091011495 @default.
- W2415616205 date "1987-07-01" @default.
- W2415616205 modified "2023-09-24" @default.
- W2415616205 title "Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study." @default.
- W2415616205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3475171" @default.
- W2415616205 hasPublicationYear "1987" @default.
- W2415616205 type Work @default.
- W2415616205 sameAs 2415616205 @default.
- W2415616205 citedByCount "3" @default.
- W2415616205 crossrefType "journal-article" @default.
- W2415616205 hasAuthorship W2415616205A5005996885 @default.
- W2415616205 hasAuthorship W2415616205A5033267787 @default.
- W2415616205 hasAuthorship W2415616205A5047404272 @default.
- W2415616205 hasAuthorship W2415616205A5065968907 @default.
- W2415616205 hasAuthorship W2415616205A5071895397 @default.
- W2415616205 hasAuthorship W2415616205A5083882513 @default.
- W2415616205 hasAuthorship W2415616205A5090228543 @default.
- W2415616205 hasAuthorship W2415616205A5091011495 @default.
- W2415616205 hasConcept C121332964 @default.
- W2415616205 hasConcept C126322002 @default.
- W2415616205 hasConcept C141071460 @default.
- W2415616205 hasConcept C142424586 @default.
- W2415616205 hasConcept C2776611710 @default.
- W2415616205 hasConcept C2776694085 @default.
- W2415616205 hasConcept C2776755627 @default.
- W2415616205 hasConcept C2777506904 @default.
- W2415616205 hasConcept C2778119113 @default.
- W2415616205 hasConcept C2778461978 @default.
- W2415616205 hasConcept C2778496288 @default.
- W2415616205 hasConcept C2778670039 @default.
- W2415616205 hasConcept C2778707968 @default.
- W2415616205 hasConcept C2780376820 @default.
- W2415616205 hasConcept C2781107101 @default.
- W2415616205 hasConcept C2781413609 @default.
- W2415616205 hasConcept C2909962599 @default.
- W2415616205 hasConcept C29730261 @default.
- W2415616205 hasConcept C71924100 @default.
- W2415616205 hasConcept C87355193 @default.
- W2415616205 hasConcept C90924648 @default.
- W2415616205 hasConceptScore W2415616205C121332964 @default.
- W2415616205 hasConceptScore W2415616205C126322002 @default.
- W2415616205 hasConceptScore W2415616205C141071460 @default.
- W2415616205 hasConceptScore W2415616205C142424586 @default.
- W2415616205 hasConceptScore W2415616205C2776611710 @default.
- W2415616205 hasConceptScore W2415616205C2776694085 @default.
- W2415616205 hasConceptScore W2415616205C2776755627 @default.
- W2415616205 hasConceptScore W2415616205C2777506904 @default.
- W2415616205 hasConceptScore W2415616205C2778119113 @default.
- W2415616205 hasConceptScore W2415616205C2778461978 @default.
- W2415616205 hasConceptScore W2415616205C2778496288 @default.
- W2415616205 hasConceptScore W2415616205C2778670039 @default.
- W2415616205 hasConceptScore W2415616205C2778707968 @default.
- W2415616205 hasConceptScore W2415616205C2780376820 @default.
- W2415616205 hasConceptScore W2415616205C2781107101 @default.
- W2415616205 hasConceptScore W2415616205C2781413609 @default.
- W2415616205 hasConceptScore W2415616205C2909962599 @default.
- W2415616205 hasConceptScore W2415616205C29730261 @default.
- W2415616205 hasConceptScore W2415616205C71924100 @default.
- W2415616205 hasConceptScore W2415616205C87355193 @default.
- W2415616205 hasConceptScore W2415616205C90924648 @default.
- W2415616205 hasLocation W24156162051 @default.
- W2415616205 hasOpenAccess W2415616205 @default.
- W2415616205 hasPrimaryLocation W24156162051 @default.
- W2415616205 hasRelatedWork W133083830 @default.
- W2415616205 hasRelatedWork W1761088866 @default.
- W2415616205 hasRelatedWork W1970522488 @default.
- W2415616205 hasRelatedWork W1971100415 @default.
- W2415616205 hasRelatedWork W1977488916 @default.
- W2415616205 hasRelatedWork W1988746054 @default.
- W2415616205 hasRelatedWork W1991058838 @default.
- W2415616205 hasRelatedWork W2006022537 @default.
- W2415616205 hasRelatedWork W2060598942 @default.
- W2415616205 hasRelatedWork W2074680528 @default.
- W2415616205 hasRelatedWork W2089287910 @default.
- W2415616205 hasRelatedWork W2106491226 @default.
- W2415616205 hasRelatedWork W2133736488 @default.
- W2415616205 hasRelatedWork W2316930251 @default.
- W2415616205 hasRelatedWork W2401306704 @default.
- W2415616205 hasRelatedWork W2412757765 @default.
- W2415616205 hasRelatedWork W2415350532 @default.
- W2415616205 hasRelatedWork W2416846145 @default.
- W2415616205 hasRelatedWork W2429116449 @default.
- W2415616205 hasRelatedWork W2479958022 @default.
- W2415616205 hasVolume "71" @default.
- W2415616205 isParatext "false" @default.
- W2415616205 isRetracted "false" @default.
- W2415616205 magId "2415616205" @default.
- W2415616205 workType "article" @default.