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• W2415646121 abstract "Myeloma facilitates destruction of bone and marrow. Since physical activity encourages musculoskeletal preservation we evaluated whether low-intensity vibration (LIV), a means to deliver mechanical signals, could protect bone and marrow during myeloma progression. Immunocompromised-mice (n = 25) were injected with human-myeloma cells, while 8 (AC) were saline-injected. Myeloma-injected mice (LIV; n = 13) were subjected to daily-mechanical loading (15 min/d; 0.3 g @ 90 Hz) while 12 (MM) were sham-handled. At 8w, femurs had 86% less trabecular bone volume fraction (BV/TV) in MM than in AC, yet only a 21% decrease in LIV was observed in comparison to AC, reflecting a 76% increase versus MM. Cortical BV was 21% and 15% lower in MM and LIV, respectively, than in AC; LIV showing 30% improvement over MM. Similar outcomes were observed in the axial skeleton, showing a 35% loss in MM with a 27% improved retention of bone in the L5 of LIV-treated mice as compared to MM. Transcortical-perforations in the femur from myeloma-induced osteolysis were 9 × higher in MM versus AC, reduced by 57% in LIV. Serum-TRACP5b, 61% greater in MM versus AC, rose by 33% in LIV compared to AC, a 45% reduction in activity when compared to MM. Histomorphometric analyses of femoral trabecular bone demonstrated a 70% elevation in eroded surfaces of MM versus AC, while measures in LIV were 58% below those in MM. 72% of marrow in the femur of MM mice contained tumor, contrasted by a 31% lower burden in LIV. MM mice (42%) presented advanced-stage necrosis of tibial marrow while present in just 8% of LIV. Myeloma infiltration inversely correlated to measures of bone quality, while LIV slowed the systemic, myeloma-associated decline in bone quality and inhibited tumor progression through the hindlimbs." @default.
• W2415646121 created "2016-06-24" @default.
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• W2415646121 date "2016-09-01" @default.
• W2415646121 modified "2023-10-14" @default.
• W2415646121 title "Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma" @default.
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• W2415646121 doi "https://doi.org/10.1016/j.bone.2016.05.014" @default.
• W2415646121 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4970889" @default.
• W2415646121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27262776" @default.
• W2415646121 hasPublicationYear "2016" @default.
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