FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415665096> ?p ?o ?g. }

• W2415665096 endingPage "L982" @default.
• W2415665096 startingPage "L974" @default.
• W2415665096 abstract "We previously demonstrated that Rac1 increased cyclin D1 promoter activity in an extracellular signal-regulated kinase (ERK)-independent, antioxidant-sensitive manner. Here, we examined the regulation of cyclin D1 expression by Cdc42 and RhoA. Overexpression of active Cdc42, but not of RhoA, induced transcription from the cyclin D1 promoter. Furthermore, dominant negative Cdc42, but not RhoA, attenuated platelet-derived growth factor-mediated activation of the cyclin D1 promoter. Overexpression of active Cdc42 increased cyclin D1 protein abundance in COS cells. Cdc42-induced cyclin D1 promoter activation was independent of ERK as evidenced by insensitivity to PD-98059, an inhibitor of mitogen-activated protein kinase/ERK kinase (MEK). Furthermore, Cdc42 was neither sufficient nor required for activation of ERK. Similar to Rac1-induced cyclin D1 expression, pretreatment with the antioxidants catalase and ebselen inhibited Cdc42-mediated transcription from the cyclin D1 promoter. Finally, like Rac1, active Cdc42 induced transactivation of the cyclin D1 promoter cAMP response element binding protein/activating transcription factor-2 binding site. Together, these data suggest that in airway smooth muscle cells, Cdc42 and Rac1 share a common signaling pathway to cyclin D1 promoter activation." @default.
• W2415665096 created "2016-06-24" @default.
• W2415665096 creator A5027613904 @default.
• W2415665096 creator A5056413630 @default.
• W2415665096 creator A5086581431 @default.
• W2415665096 date "2001-05-01" @default.
• W2415665096 modified "2023-10-15" @default.
• W2415665096 title "Cdc42, but not RhoA, regulates cyclin D1 expression in bovine tracheal myocytes" @default.
• W2415665096 cites W1541051315 @default.
• W2415665096 cites W1555692789 @default.
• W2415665096 cites W1968697776 @default.
• W2415665096 cites W1985462906 @default.
• W2415665096 cites W1992772703 @default.
• W2415665096 cites W1995209206 @default.
• W2415665096 cites W2000862518 @default.
• W2415665096 cites W2002410732 @default.
• W2415665096 cites W2005900169 @default.
• W2415665096 cites W2026578973 @default.
• W2415665096 cites W2027810531 @default.
• W2415665096 cites W2042584344 @default.
• W2415665096 cites W2047415777 @default.
• W2415665096 cites W2049216745 @default.
• W2415665096 cites W2053257956 @default.
• W2415665096 cites W2055181868 @default.
• W2415665096 cites W2065209133 @default.
• W2415665096 cites W2066689232 @default.
• W2415665096 cites W2084699108 @default.
• W2415665096 cites W2085136839 @default.
• W2415665096 cites W2087172814 @default.
• W2415665096 cites W2088274904 @default.
• W2415665096 cites W2090891207 @default.
• W2415665096 cites W2093226717 @default.
• W2415665096 cites W2096791952 @default.
• W2415665096 cites W2115368090 @default.
• W2415665096 cites W2118145436 @default.
• W2415665096 cites W2118833233 @default.
• W2415665096 cites W2126375358 @default.
• W2415665096 cites W2127150495 @default.
• W2415665096 cites W2139451284 @default.
• W2415665096 cites W2147084019 @default.
• W2415665096 cites W2170906235 @default.
• W2415665096 cites W2188131212 @default.
• W2415665096 cites W2255988667 @default.
• W2415665096 cites W2270329964 @default.
• W2415665096 cites W2472988897 @default.
• W2415665096 cites W4230115649 @default.
• W2415665096 cites W72481024 @default.
• W2415665096 doi "https://doi.org/10.1152/ajplung.2001.280.5.l974" @default.
• W2415665096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11290522" @default.
• W2415665096 hasPublicationYear "2001" @default.
• W2415665096 type Work @default.
• W2415665096 sameAs 2415665096 @default.
• W2415665096 citedByCount "27" @default.
• W2415665096 countsByYear W24156650962012 @default.
• W2415665096 countsByYear W24156650962013 @default.
• W2415665096 countsByYear W24156650962014 @default.
• W2415665096 countsByYear W24156650962015 @default.
• W2415665096 countsByYear W24156650962019 @default.
• W2415665096 countsByYear W24156650962022 @default.
• W2415665096 crossrefType "journal-article" @default.
• W2415665096 hasAuthorship W2415665096A5027613904 @default.
• W2415665096 hasAuthorship W2415665096A5056413630 @default.
• W2415665096 hasAuthorship W2415665096A5086581431 @default.
• W2415665096 hasBestOaLocation W24156650961 @default.
• W2415665096 hasConcept C11882975 @default.
• W2415665096 hasConcept C1491633281 @default.
• W2415665096 hasConcept C153911025 @default.
• W2415665096 hasConcept C16438837 @default.
• W2415665096 hasConcept C184235292 @default.
• W2415665096 hasConcept C185592680 @default.
• W2415665096 hasConcept C199835354 @default.
• W2415665096 hasConcept C2777093181 @default.
• W2415665096 hasConcept C2780040266 @default.
• W2415665096 hasConcept C28179978 @default.
• W2415665096 hasConcept C29537977 @default.
• W2415665096 hasConcept C502942594 @default.
• W2415665096 hasConcept C55493867 @default.
• W2415665096 hasConcept C62478195 @default.
• W2415665096 hasConcept C82495950 @default.
• W2415665096 hasConcept C86803240 @default.
• W2415665096 hasConcept C95444343 @default.
• W2415665096 hasConcept C97029542 @default.
• W2415665096 hasConceptScore W2415665096C11882975 @default.
• W2415665096 hasConceptScore W2415665096C1491633281 @default.
• W2415665096 hasConceptScore W2415665096C153911025 @default.
• W2415665096 hasConceptScore W2415665096C16438837 @default.
• W2415665096 hasConceptScore W2415665096C184235292 @default.
• W2415665096 hasConceptScore W2415665096C185592680 @default.
• W2415665096 hasConceptScore W2415665096C199835354 @default.
• W2415665096 hasConceptScore W2415665096C2777093181 @default.
• W2415665096 hasConceptScore W2415665096C2780040266 @default.
• W2415665096 hasConceptScore W2415665096C28179978 @default.
• W2415665096 hasConceptScore W2415665096C29537977 @default.
• W2415665096 hasConceptScore W2415665096C502942594 @default.
• W2415665096 hasConceptScore W2415665096C55493867 @default.
• W2415665096 hasConceptScore W2415665096C62478195 @default.
• W2415665096 hasConceptScore W2415665096C82495950 @default.
• W2415665096 hasConceptScore W2415665096C86803240 @default.

• next