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- W2415665499 abstract "Series of methyl esters of stereoisomeric dipeptides of the sequences Tyr-Arg and Arg-Tyr has been synthesized by classic methods of the peptide chemistry. The study of their reactivity towards thrombin and trypsin has shown that the kinetic parameters of enzyme-catalyzed hydrolyses of stereoisomeric compounds differ in values essentially. Testing the synthetic peptides on analgic effect, on inhibition of the reaction fibrinogen with thrombin or on influence upon the process of fibrin-monomer polymerization has shown that these biological effects depend on peptide structure and on configuration of amino acid residues forming the peptides." @default.
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- W2415665499 date "1999-12-28" @default.
- W2415665499 modified "2023-09-25" @default.
- W2415665499 title "[Synthesis and study of biological activity of stereoisomeric dipeptides containing tyrosine and arginine residues]." @default.
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