FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415669784> ?p ?o ?g. }

• W2415669784 endingPage "178" @default.
• W2415669784 startingPage "169" @default.
• W2415669784 abstract "The aim was to examine the effect of free fatty acids on the regulation of PPARγ-PGC1α pathway, and the effect of PPARγ/PGC1α in NAFLD. The mRNA and protein expression of PGC1α and phospho/total PPARγ were examined in Huh7 cells after the palmitate/oleate treatment with/without the transfection with siRNA against PGC1a. The palmitate content, mRNA and protein expression of PGC1α and PPARγ in the liver were examined in the control and NAFLD mice. Palmitate (500 μM), but not oleate, increased protein expression of PGC1α and phospho PPARγ (PGC1α, 1.42-fold, P=0.038; phospho PPARγ, 1.56-fold, P=0.022). The palmitate-induced PPARγ mRNA expression was reduced after the transfection (0.46‑fold), and the protein expressions of PGC1α (0.52-fold, P=0.019) and phospho PPARγ (0.43-fold, P=0.011) were suppressed in siRNA-transfected cells. The palmitate (12325.8 ± 1758.9 μg/g vs. 6245.6 ± 1182.7 μg/g, p=0.002), and mRNA expression of PGC1α (11.0 vs. 5.5, p=0.03) and PPARγ (4.3 vs. 2.2, p=0.0001) in the liver were higher in high-triglyceride liver mice (>15.2 mg/g) than in low-triglyceride liver mice (<15.2 mg/g). The protein expressions of both PGC1α and PPARγ were higher in the NAFLD group than in the controls (PGC1α, 1.41-fold, P=0.035; PPARγ, 1.39-fold, P=0.042), and were higher in the high-triglyceride liver group (PGC1α, 1.52-fold, p=0.03; PPARγ, 1.22-fold, p=0.05) than in the low-triglyceride liver group. In conclusion, palmitate appear to up-regulate PPARγ via PGC1α in Huh7 cells, and both PGC1α and PPARγ are up-regulated in the NAFLD mice liver, suggesting an effect on lipid metabolism leading to intrahepatic triglyceride accumulation." @default.
• W2415669784 created "2016-06-24" @default.
• W2415669784 creator A5014348565 @default.
• W2415669784 creator A5016770705 @default.
• W2415669784 creator A5019932826 @default.
• W2415669784 creator A5035221784 @default.
• W2415669784 creator A5082785148 @default.
• W2415669784 date "2016-01-01" @default.
• W2415669784 modified "2023-10-16" @default.
• W2415669784 title "Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease" @default.
• W2415669784 cites W1559792721 @default.
• W2415669784 cites W1968243232 @default.
• W2415669784 cites W1968384054 @default.
• W2415669784 cites W1971679612 @default.
• W2415669784 cites W1975418306 @default.
• W2415669784 cites W1984077928 @default.
• W2415669784 cites W1989908272 @default.
• W2415669784 cites W2000065704 @default.
• W2415669784 cites W2001177059 @default.
• W2415669784 cites W2007887164 @default.
• W2415669784 cites W2013281318 @default.
• W2415669784 cites W2018427433 @default.
• W2415669784 cites W2026450587 @default.
• W2415669784 cites W2047257800 @default.
• W2415669784 cites W2047982128 @default.
• W2415669784 cites W2054208989 @default.
• W2415669784 cites W2060906515 @default.
• W2415669784 cites W2073578030 @default.
• W2415669784 cites W2074203821 @default.
• W2415669784 cites W2078176020 @default.
• W2415669784 cites W2086040049 @default.
• W2415669784 cites W2088371362 @default.
• W2415669784 cites W2089714144 @default.
• W2415669784 cites W2091673304 @default.
• W2415669784 cites W2093824918 @default.
• W2415669784 cites W2094879159 @default.
• W2415669784 cites W2098555833 @default.
• W2415669784 cites W2106061083 @default.
• W2415669784 cites W2123476161 @default.
• W2415669784 cites W2129722153 @default.
• W2415669784 cites W2142844314 @default.
• W2415669784 cites W2144535719 @default.
• W2415669784 cites W2148877387 @default.
• W2415669784 cites W2151669289 @default.
• W2415669784 cites W2157199218 @default.
• W2415669784 cites W2159742257 @default.
• W2415669784 cites W2161883681 @default.
• W2415669784 cites W2166948421 @default.
• W2415669784 cites W2168526937 @default.
• W2415669784 cites W2168729166 @default.
• W2415669784 cites W2253667517 @default.
• W2415669784 doi "https://doi.org/10.7150/ijms.13581" @default.
• W2415669784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773281" @default.
• W2415669784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26941577" @default.
• W2415669784 hasPublicationYear "2016" @default.
• W2415669784 type Work @default.
• W2415669784 sameAs 2415669784 @default.
• W2415669784 citedByCount "24" @default.
• W2415669784 countsByYear W24156697842016 @default.
• W2415669784 countsByYear W24156697842017 @default.
• W2415669784 countsByYear W24156697842018 @default.
• W2415669784 countsByYear W24156697842019 @default.
• W2415669784 countsByYear W24156697842020 @default.
• W2415669784 countsByYear W24156697842021 @default.
• W2415669784 countsByYear W24156697842022 @default.
• W2415669784 countsByYear W24156697842023 @default.
• W2415669784 crossrefType "journal-article" @default.
• W2415669784 hasAuthorship W2415669784A5014348565 @default.
• W2415669784 hasAuthorship W2415669784A5016770705 @default.
• W2415669784 hasAuthorship W2415669784A5019932826 @default.
• W2415669784 hasAuthorship W2415669784A5035221784 @default.
• W2415669784 hasAuthorship W2415669784A5082785148 @default.
• W2415669784 hasBestOaLocation W24156697841 @default.
• W2415669784 hasConcept C104317684 @default.
• W2415669784 hasConcept C105580179 @default.
• W2415669784 hasConcept C126322002 @default.
• W2415669784 hasConcept C127078168 @default.
• W2415669784 hasConcept C134018914 @default.
• W2415669784 hasConcept C170493617 @default.
• W2415669784 hasConcept C185592680 @default.
• W2415669784 hasConcept C187345961 @default.
• W2415669784 hasConcept C2776175330 @default.
• W2415669784 hasConcept C2776954865 @default.
• W2415669784 hasConcept C2778163477 @default.
• W2415669784 hasConcept C2778772119 @default.
• W2415669784 hasConcept C2778913445 @default.
• W2415669784 hasConcept C2779134260 @default.
• W2415669784 hasConcept C54009773 @default.
• W2415669784 hasConcept C55493867 @default.
• W2415669784 hasConcept C71924100 @default.
• W2415669784 hasConcept C86803240 @default.
• W2415669784 hasConceptScore W2415669784C104317684 @default.
• W2415669784 hasConceptScore W2415669784C105580179 @default.
• W2415669784 hasConceptScore W2415669784C126322002 @default.
• W2415669784 hasConceptScore W2415669784C127078168 @default.
• W2415669784 hasConceptScore W2415669784C134018914 @default.
• W2415669784 hasConceptScore W2415669784C170493617 @default.
• W2415669784 hasConceptScore W2415669784C185592680 @default.

• next