Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415671132> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2415671132 endingPage "19" @default.
- W2415671132 startingPage "14" @default.
- W2415671132 abstract "The opening and closing of chloride (Cl-) channels in the apical membrane of epithelial cells is regulated by hormones, neurotransmitters and enterotoxins (intestine) acting through a variety of intracellular messengers, including cyclic nucleotides (cAMP, cGMP), calcium (Ca) and diacylglycerol (DAG). The chloride impermeability of epithelial membranes observed in cystic fibrosis (CF) patients does not result from a defect in the Cl- conducting properties of the channel or in channel recruitment but stems either from a defect in a key regulator of the channel, presumably a phosphoprotein, or from the hyperactivation of a channel closing mechanism, presumably a protein phosphatase or a down-regulating protein kinase (i.e. protein kinase C). In vitro phosphorylation of isolated intestinal brush border membranes has revealed the existence of a 25,000 molecular weight proteolipid (p25) acting as cosubstrate for both cGMP- and cAMP-dependent protein kinases and cross-reacting with antibodies directed against the cytoplasmic tail of the band 3 anion exchanger from erythrocytes. The putative role of p25 in Cl- channel regulation and its relationship to an unidentified GTP-binding protein recently implicated in Cl- channel activation is discussed on the basis of a regulatory model indicating potential sites of the CF defect at a molecular level." @default.
- W2415671132 created "2016-06-24" @default.
- W2415671132 creator A5043109979 @default.
- W2415671132 date "1989-11-01" @default.
- W2415671132 modified "2023-10-16" @default.
- W2415671132 title "The Molecular Basis of Chloride Channel Dysregulation in Cystic Fibrosis" @default.
- W2415671132 cites W152157807 @default.
- W2415671132 cites W1973868711 @default.
- W2415671132 cites W1979496441 @default.
- W2415671132 cites W198432336 @default.
- W2415671132 cites W2003724450 @default.
- W2415671132 cites W2009006060 @default.
- W2415671132 cites W2020142217 @default.
- W2415671132 cites W2034368055 @default.
- W2415671132 cites W2045269940 @default.
- W2415671132 cites W2057474701 @default.
- W2415671132 cites W2084344048 @default.
- W2415671132 cites W2086211966 @default.
- W2415671132 cites W2126458759 @default.
- W2415671132 cites W2159393409 @default.
- W2415671132 cites W2302567891 @default.
- W2415671132 cites W2407064989 @default.
- W2415671132 cites W2410214285 @default.
- W2415671132 doi "https://doi.org/10.1111/apa.1989.78.s363.14" @default.
- W2415671132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2701919" @default.
- W2415671132 hasPublicationYear "1989" @default.
- W2415671132 type Work @default.
- W2415671132 sameAs 2415671132 @default.
- W2415671132 citedByCount "6" @default.
- W2415671132 countsByYear W24156711322016 @default.
- W2415671132 crossrefType "journal-article" @default.
- W2415671132 hasAuthorship W2415671132A5043109979 @default.
- W2415671132 hasConcept C104317684 @default.
- W2415671132 hasConcept C11960822 @default.
- W2415671132 hasConcept C145822097 @default.
- W2415671132 hasConcept C163235415 @default.
- W2415671132 hasConcept C184235292 @default.
- W2415671132 hasConcept C195794163 @default.
- W2415671132 hasConcept C2777061661 @default.
- W2415671132 hasConcept C2778428886 @default.
- W2415671132 hasConcept C3018436504 @default.
- W2415671132 hasConcept C36020004 @default.
- W2415671132 hasConcept C41625074 @default.
- W2415671132 hasConcept C55493867 @default.
- W2415671132 hasConcept C79879829 @default.
- W2415671132 hasConcept C86803240 @default.
- W2415671132 hasConcept C95444343 @default.
- W2415671132 hasConcept C97029542 @default.
- W2415671132 hasConceptScore W2415671132C104317684 @default.
- W2415671132 hasConceptScore W2415671132C11960822 @default.
- W2415671132 hasConceptScore W2415671132C145822097 @default.
- W2415671132 hasConceptScore W2415671132C163235415 @default.
- W2415671132 hasConceptScore W2415671132C184235292 @default.
- W2415671132 hasConceptScore W2415671132C195794163 @default.
- W2415671132 hasConceptScore W2415671132C2777061661 @default.
- W2415671132 hasConceptScore W2415671132C2778428886 @default.
- W2415671132 hasConceptScore W2415671132C3018436504 @default.
- W2415671132 hasConceptScore W2415671132C36020004 @default.
- W2415671132 hasConceptScore W2415671132C41625074 @default.
- W2415671132 hasConceptScore W2415671132C55493867 @default.
- W2415671132 hasConceptScore W2415671132C79879829 @default.
- W2415671132 hasConceptScore W2415671132C86803240 @default.
- W2415671132 hasConceptScore W2415671132C95444343 @default.
- W2415671132 hasConceptScore W2415671132C97029542 @default.
- W2415671132 hasIssue "S363" @default.
- W2415671132 hasLocation W24156711321 @default.
- W2415671132 hasLocation W24156711322 @default.
- W2415671132 hasOpenAccess W2415671132 @default.
- W2415671132 hasPrimaryLocation W24156711321 @default.
- W2415671132 hasRelatedWork W1975617042 @default.
- W2415671132 hasRelatedWork W1989009320 @default.
- W2415671132 hasRelatedWork W1996890418 @default.
- W2415671132 hasRelatedWork W2003724450 @default.
- W2415671132 hasRelatedWork W2045759164 @default.
- W2415671132 hasRelatedWork W2083363920 @default.
- W2415671132 hasRelatedWork W2165627203 @default.
- W2415671132 hasRelatedWork W2415671132 @default.
- W2415671132 hasRelatedWork W69507883 @default.
- W2415671132 hasRelatedWork W2410017321 @default.
- W2415671132 hasVolume "78" @default.
- W2415671132 isParatext "false" @default.
- W2415671132 isRetracted "false" @default.
- W2415671132 magId "2415671132" @default.
- W2415671132 workType "article" @default.