Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415672814> ?p ?o ?g. }
- W2415672814 endingPage "40" @default.
- W2415672814 startingPage "28" @default.
- W2415672814 abstract "The aim of the present study was to test the hypothesis that immobilisation of bone morphogenic proteins on the surface of titanium implants through nano-anchored oligonucleotides can enhance peri-implant bone formation. Non-coding 60-mer DNA oligonucleotides (ODN) were anchored to the surface of custom made sandblasted acid etched (SAE) titanium screw implants through anodic polarisation, gamma-sterilised with a standard dose of 25 kGy, and were hybridised with complementary 30-mer strands of DNA oligonucleotides conjugated to rhBMP2. Blank SAE implants, SAE implants with nano-anchored ODN and SAE implants with nano-anchored ODN and non-conjugated rhBMP2 served as controls. The implants were inserted into the tibiae of 36 Sprague Dawley rats. Perforations at the head and the tip of the implants allowed for bone ingrowth. Bone ingrowth into perforations and bone implant contact (BIC) as well as bone density (BD) at a distance of 200 µm from the implant surface were assessed after 1 , 4 and 13 weeks. Implants with nano-anchored ODN strands hybridised with conjugated rhBMP2 exhibited enhanced bone ingrowth into the perforations and increased BIC after 1 week as well as increased BIC after 4 weeks compared to controls. No difference was seen after 13 weeks. Bone density around the outer implant surface did not differ significantly at any of the intervals. It is concluded that rhBMP2 immobilised on the surface of titanium implants through nano-anchored oligonucleotide strands can enhance bone implant contact. The conditions of sterilisation tested allowed for handling under clinically relevant conditions." @default.
- W2415672814 created "2016-06-24" @default.
- W2415672814 creator A5043322923 @default.
- W2415672814 creator A5045665079 @default.
- W2415672814 creator A5052184805 @default.
- W2415672814 creator A5070068146 @default.
- W2415672814 creator A5079276270 @default.
- W2415672814 creator A5079838664 @default.
- W2415672814 creator A5083909764 @default.
- W2415672814 date "2015-07-27" @default.
- W2415672814 modified "2023-09-28" @default.
- W2415672814 title "In vivo effect of immobilisation of bone morphogenic protein 2 on titanium implants through nano-anchored oligonucleotides" @default.
- W2415672814 cites W1803555116 @default.
- W2415672814 cites W1956900752 @default.
- W2415672814 cites W1963800214 @default.
- W2415672814 cites W1972842432 @default.
- W2415672814 cites W1982479589 @default.
- W2415672814 cites W1990241231 @default.
- W2415672814 cites W1994984182 @default.
- W2415672814 cites W1998602216 @default.
- W2415672814 cites W2011384823 @default.
- W2415672814 cites W2014024885 @default.
- W2415672814 cites W2021527865 @default.
- W2415672814 cites W2022716570 @default.
- W2415672814 cites W2053155134 @default.
- W2415672814 cites W2059151377 @default.
- W2415672814 cites W2071059905 @default.
- W2415672814 cites W2074427206 @default.
- W2415672814 cites W2075019981 @default.
- W2415672814 cites W2081315067 @default.
- W2415672814 cites W2086498142 @default.
- W2415672814 cites W2087460497 @default.
- W2415672814 cites W2089619883 @default.
- W2415672814 cites W2090752650 @default.
- W2415672814 cites W2111497365 @default.
- W2415672814 cites W2111846867 @default.
- W2415672814 cites W2143532808 @default.
- W2415672814 cites W2150456951 @default.
- W2415672814 cites W2154382909 @default.
- W2415672814 cites W2160935121 @default.
- W2415672814 cites W2186105570 @default.
- W2415672814 doi "https://doi.org/10.22203/ecm.v030a03" @default.
- W2415672814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26214288" @default.
- W2415672814 hasPublicationYear "2015" @default.
- W2415672814 type Work @default.
- W2415672814 sameAs 2415672814 @default.
- W2415672814 citedByCount "8" @default.
- W2415672814 countsByYear W24156728142016 @default.
- W2415672814 countsByYear W24156728142017 @default.
- W2415672814 countsByYear W24156728142018 @default.
- W2415672814 countsByYear W24156728142020 @default.
- W2415672814 countsByYear W24156728142021 @default.
- W2415672814 countsByYear W24156728142023 @default.
- W2415672814 crossrefType "journal-article" @default.
- W2415672814 hasAuthorship W2415672814A5043322923 @default.
- W2415672814 hasAuthorship W2415672814A5045665079 @default.
- W2415672814 hasAuthorship W2415672814A5052184805 @default.
- W2415672814 hasAuthorship W2415672814A5070068146 @default.
- W2415672814 hasAuthorship W2415672814A5079276270 @default.
- W2415672814 hasAuthorship W2415672814A5079838664 @default.
- W2415672814 hasAuthorship W2415672814A5083909764 @default.
- W2415672814 hasBestOaLocation W24156728141 @default.
- W2415672814 hasConcept C101414908 @default.
- W2415672814 hasConcept C104317684 @default.
- W2415672814 hasConcept C129312508 @default.
- W2415672814 hasConcept C136229726 @default.
- W2415672814 hasConcept C141071460 @default.
- W2415672814 hasConcept C150903083 @default.
- W2415672814 hasConcept C185592680 @default.
- W2415672814 hasConcept C191897082 @default.
- W2415672814 hasConcept C192562407 @default.
- W2415672814 hasConcept C199343813 @default.
- W2415672814 hasConcept C202751555 @default.
- W2415672814 hasConcept C207001950 @default.
- W2415672814 hasConcept C2781411149 @default.
- W2415672814 hasConcept C30352789 @default.
- W2415672814 hasConcept C31507581 @default.
- W2415672814 hasConcept C506065880 @default.
- W2415672814 hasConcept C552990157 @default.
- W2415672814 hasConcept C55493867 @default.
- W2415672814 hasConcept C71924100 @default.
- W2415672814 hasConcept C86803240 @default.
- W2415672814 hasConceptScore W2415672814C101414908 @default.
- W2415672814 hasConceptScore W2415672814C104317684 @default.
- W2415672814 hasConceptScore W2415672814C129312508 @default.
- W2415672814 hasConceptScore W2415672814C136229726 @default.
- W2415672814 hasConceptScore W2415672814C141071460 @default.
- W2415672814 hasConceptScore W2415672814C150903083 @default.
- W2415672814 hasConceptScore W2415672814C185592680 @default.
- W2415672814 hasConceptScore W2415672814C191897082 @default.
- W2415672814 hasConceptScore W2415672814C192562407 @default.
- W2415672814 hasConceptScore W2415672814C199343813 @default.
- W2415672814 hasConceptScore W2415672814C202751555 @default.
- W2415672814 hasConceptScore W2415672814C207001950 @default.
- W2415672814 hasConceptScore W2415672814C2781411149 @default.
- W2415672814 hasConceptScore W2415672814C30352789 @default.
- W2415672814 hasConceptScore W2415672814C31507581 @default.
- W2415672814 hasConceptScore W2415672814C506065880 @default.