FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415676890> ?p ?o ?g. }

• W2415676890 abstract "Massively parallel sequencing technologies have enabled characterization of genomic alterations across multiple tumor types. Efforts have focused on identifying driver mutations because they represent potential targets for therapy. However, because of the presence of driver and passenger mutations, it is often challenging to assign the clinical relevance of specific mutations observed in patients. Currently, there are multiple databases and tools that provide in silico assessment for potential drivers; however, there is no comprehensive resource for mutations with functional characterization. Therefore, we created an expert-curated database of potentially actionable driver mutations for molecular pathologists to facilitate annotation of cancer genomic testing. We reviewed scientific literature to identify variants that have been functionally characterized in vitro or in vivo as driver mutations. We obtained the chromosome location and all possible nucleotide positions for each amino acid change and uploaded them to the Cancer Driver Log (CanDL) database with associated literature reference indicating functional driver evidence. In addition to a simple interface, the database allows users to download all or selected genes as a comma-separated values file for incorporation into their own analysis pipeline. Furthermore, the database includes a mechanism for third-party contributions to support updates for novel driver mutations. Overall, this freely available database will facilitate rapid annotation of cancer genomic testing in molecular pathology laboratories for mutations. (J Mol Diagn" @default.
• W2415676890 created "2016-06-24" @default.
• W2415676890 creator A5003346438 @default.
• W2415676890 creator A5012759462 @default.
• W2415676890 creator A5015991126 @default.
• W2415676890 creator A5022618072 @default.
• W2415676890 creator A5036692993 @default.
• W2415676890 creator A5062643378 @default.
• W2415676890 creator A5064582385 @default.
• W2415676890 creator A5088856020 @default.
• W2415676890 date "2015-01-01" @default.
• W2415676890 modified "2023-09-23" @default.
• W2415676890 title "Cancer Driver Log (CanDL) Catalog of Potentially Actionable Cancer" @default.
• W2415676890 cites W1976815080 @default.
• W2415676890 cites W1980852206 @default.
• W2415676890 cites W1984068087 @default.
• W2415676890 cites W2009720434 @default.
• W2415676890 cites W2018023891 @default.
• W2415676890 cites W2021341670 @default.
• W2415676890 cites W2022888482 @default.
• W2415676890 cites W2032917923 @default.
• W2415676890 cites W2044060805 @default.
• W2415676890 cites W2053968609 @default.
• W2415676890 cites W2069676201 @default.
• W2415676890 cites W2091383172 @default.
• W2415676890 cites W2102140136 @default.
• W2415676890 cites W2107396506 @default.
• W2415676890 cites W2110139885 @default.
• W2415676890 cites W2114843025 @default.
• W2415676890 cites W2118151336 @default.
• W2415676890 cites W2138044466 @default.
• W2415676890 cites W2141432783 @default.
• W2415676890 cites W2152061559 @default.
• W2415676890 cites W2160981405 @default.
• W2415676890 hasPublicationYear "2015" @default.
• W2415676890 type Work @default.
• W2415676890 sameAs 2415676890 @default.
• W2415676890 citedByCount "0" @default.
• W2415676890 crossrefType "journal-article" @default.
• W2415676890 hasAuthorship W2415676890A5003346438 @default.
• W2415676890 hasAuthorship W2415676890A5012759462 @default.
• W2415676890 hasAuthorship W2415676890A5015991126 @default.
• W2415676890 hasAuthorship W2415676890A5022618072 @default.
• W2415676890 hasAuthorship W2415676890A5036692993 @default.
• W2415676890 hasAuthorship W2415676890A5062643378 @default.
• W2415676890 hasAuthorship W2415676890A5064582385 @default.
• W2415676890 hasAuthorship W2415676890A5088856020 @default.
• W2415676890 hasConcept C104317684 @default.
• W2415676890 hasConcept C121608353 @default.
• W2415676890 hasConcept C136764020 @default.
• W2415676890 hasConcept C141231307 @default.
• W2415676890 hasConcept C189206191 @default.
• W2415676890 hasConcept C192800701 @default.
• W2415676890 hasConcept C2775905019 @default.
• W2415676890 hasConcept C2776321320 @default.
• W2415676890 hasConcept C41008148 @default.
• W2415676890 hasConcept C501734568 @default.
• W2415676890 hasConcept C54355233 @default.
• W2415676890 hasConcept C60644358 @default.
• W2415676890 hasConcept C70721500 @default.
• W2415676890 hasConcept C71901391 @default.
• W2415676890 hasConcept C77088390 @default.
• W2415676890 hasConcept C86803240 @default.
• W2415676890 hasConceptScore W2415676890C104317684 @default.
• W2415676890 hasConceptScore W2415676890C121608353 @default.
• W2415676890 hasConceptScore W2415676890C136764020 @default.
• W2415676890 hasConceptScore W2415676890C141231307 @default.
• W2415676890 hasConceptScore W2415676890C189206191 @default.
• W2415676890 hasConceptScore W2415676890C192800701 @default.
• W2415676890 hasConceptScore W2415676890C2775905019 @default.
• W2415676890 hasConceptScore W2415676890C2776321320 @default.
• W2415676890 hasConceptScore W2415676890C41008148 @default.
• W2415676890 hasConceptScore W2415676890C501734568 @default.
• W2415676890 hasConceptScore W2415676890C54355233 @default.
• W2415676890 hasConceptScore W2415676890C60644358 @default.
• W2415676890 hasConceptScore W2415676890C70721500 @default.
• W2415676890 hasConceptScore W2415676890C71901391 @default.
• W2415676890 hasConceptScore W2415676890C77088390 @default.
• W2415676890 hasConceptScore W2415676890C86803240 @default.
• W2415676890 hasLocation W24156768901 @default.
• W2415676890 hasOpenAccess W2415676890 @default.
• W2415676890 hasPrimaryLocation W24156768901 @default.
• W2415676890 hasRelatedWork W2015934154 @default.
• W2415676890 hasRelatedWork W2035242162 @default.
• W2415676890 hasRelatedWork W2079561996 @default.
• W2415676890 hasRelatedWork W2096460732 @default.
• W2415676890 hasRelatedWork W2108536360 @default.
• W2415676890 hasRelatedWork W2137506169 @default.
• W2415676890 hasRelatedWork W2179763962 @default.
• W2415676890 hasRelatedWork W2204903553 @default.
• W2415676890 hasRelatedWork W2560866543 @default.
• W2415676890 hasRelatedWork W2562536836 @default.
• W2415676890 hasRelatedWork W2904586692 @default.
• W2415676890 hasRelatedWork W2915985943 @default.
• W2415676890 hasRelatedWork W2985613549 @default.
• W2415676890 hasRelatedWork W3011574558 @default.
• W2415676890 hasRelatedWork W3101645555 @default.
• W2415676890 hasRelatedWork W3102511245 @default.
• W2415676890 hasRelatedWork W3129140812 @default.
• W2415676890 hasRelatedWork W3135457246 @default.

• next