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• W2415678705 abstract "A STUDY has been undertaken to determine whether or not cortisone will influence bronchial asthma and hay fever resulting from sensitivity to ragweed pollen. A number of general facts have suggested the possible value of such a study. Experimental data have interlinked three systems and mechanisms of the body : the adrenal cortex, lymphoid tissue, and reactions of immunity. A pituitary-adrenal control influences the occurrence and severity of anaphylactic shock by enhancing resistance to this form of trauma.‘, 2 The tolerance to the deleterious effects of histamine is decreased when an animal is deprived of the function of its adrenal cortex.“-F The transport and, likewise, the possible formation of antibodies in lymphoid tissue7-‘0 is significant when considered with the fact that the adrenal hormones can effect a degeneration of lymphoid tissue.‘l, I2 Evidence suggests that the adrenal cortex can influence the titer of circulating immune bodies, and that extracts of this gland can bring about an anamnestic response.13 In this study of the allergic state we have selected for consideration the adrena, cortical fract,ion cortisone (17-hydroxy-11-dehydrocorticosterone) . Among the several hormones of the adrenal cortex cortisone has been demonstrated to be effective in bringing about lymphocytic degeneration in tissue culture experiments,12 in neoplastic lymphoid tumors,14T I5 and possibly in circulating lymphoid tissue.‘” Cortisone, and adrenal cortical extracts containing cortisone, will effect an anamnestic resp0nse.l” Cortisone is in the ll-oxysteroid fraction of adrenal cortical extract which generally has been effective in bringing about lymphocytic degeneration and in evoking an anamnestic resp0nse.l” As diseases for consideration in this study of the allergic state we have selected seasonally occurring bronchial asthma and hay fever. Among allergic disorders these diseases are unique in affording suitable methods of control in such a study. Symptoms may be severe, are of relatively constant occurrence, and afford a means of objective evaluation. The symptoms experienced in pollinosis are of sufficient duration to afford an opportunity for both control and test studies to be made on a single subject. The degree of exposure of a patient to an offending allergen may be estimated with reasonable accuracy by a day-to-day study of the pollen content of the air. Among the allergic dis-" @default.
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• W2415678705 date "1950-08-16" @default.
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• W2415678705 title "Effects of cortisone on bronchial asthma and hay fever occurring in subjects sensitive to ragweed pollen." @default.
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