Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415692417> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2415692417 endingPage "366" @default.
- W2415692417 startingPage "355" @default.
- W2415692417 abstract "RNA interference mediated by small interfering RNAs (siRNAs) is a powerful tool for evaluating gene function in vivo. In particular it should be able to provide tissue-specific and developmental stage-specific knockdown of target genes in physiological contexts. However, there are few demonstrations of its use on neuronal specific genes in vivo. We recently developed a cationic lipid-based approach to study gene function in a neuronal context. In particular, we applied it to study how the novel partner for TR $beta$ 1, hepatitis virus B X-associated protein 2 (XAP2), a protein first identified as a co-chaperone protein, affects T3-transcriptional repression of the hypothalamic gene, TRH. The cationic lipid-based technique used, JetSI/DOPE, was previously shown to efficiently knockdown reporter gene mRNA in vivo. Using JetSI/DOPE to vectorize siRNA against XAP2 mRNA, we show that XAP2 is needed specifically for TR $beta$ 1-mediated (but not TR $beta$ 2) activation of hypothalamic TRH transcription. Thus, this cationic lipid-based siRNA strategy can effectively be used to reveal fine, tissue-specific and isoform-specific effects on neuronal gene transcription in vivo." @default.
- W2415692417 created "2016-06-24" @default.
- W2415692417 creator A5003494511 @default.
- W2415692417 creator A5010387241 @default.
- W2415692417 creator A5014766406 @default.
- W2415692417 date "2008-01-01" @default.
- W2415692417 modified "2023-10-15" @default.
- W2415692417 title "In Vivo siRNA Delivery to the Mouse Hypothalamus Shows a Role of the Co-Chaperone XAP2 in Regulating TRH Transcription" @default.
- W2415692417 cites W1611419331 @default.
- W2415692417 cites W1647075334 @default.
- W2415692417 cites W1751203088 @default.
- W2415692417 cites W1916491745 @default.
- W2415692417 cites W1974303227 @default.
- W2415692417 cites W1996163490 @default.
- W2415692417 cites W2011743410 @default.
- W2415692417 cites W2015751591 @default.
- W2415692417 cites W2046094921 @default.
- W2415692417 cites W2053018567 @default.
- W2415692417 cites W2059457521 @default.
- W2415692417 cites W2062818823 @default.
- W2415692417 cites W2080758920 @default.
- W2415692417 cites W2101083359 @default.
- W2415692417 cites W2102880335 @default.
- W2415692417 cites W2117991391 @default.
- W2415692417 cites W2118270653 @default.
- W2415692417 cites W2118688982 @default.
- W2415692417 cites W2141306531 @default.
- W2415692417 cites W2141738832 @default.
- W2415692417 cites W2145159785 @default.
- W2415692417 cites W2171757104 @default.
- W2415692417 cites W266477159 @default.
- W2415692417 cites W4211039187 @default.
- W2415692417 doi "https://doi.org/10.1007/978-1-59745-237-3_21" @default.
- W2415692417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18679634" @default.
- W2415692417 hasPublicationYear "2008" @default.
- W2415692417 type Work @default.
- W2415692417 sameAs 2415692417 @default.
- W2415692417 citedByCount "3" @default.
- W2415692417 crossrefType "book-chapter" @default.
- W2415692417 hasAuthorship W2415692417A5003494511 @default.
- W2415692417 hasAuthorship W2415692417A5010387241 @default.
- W2415692417 hasAuthorship W2415692417A5014766406 @default.
- W2415692417 hasConcept C104317684 @default.
- W2415692417 hasConcept C105580179 @default.
- W2415692417 hasConcept C138885662 @default.
- W2415692417 hasConcept C150194340 @default.
- W2415692417 hasConcept C153911025 @default.
- W2415692417 hasConcept C161733203 @default.
- W2415692417 hasConcept C166703698 @default.
- W2415692417 hasConcept C173396325 @default.
- W2415692417 hasConcept C179926584 @default.
- W2415692417 hasConcept C207001950 @default.
- W2415692417 hasConcept C22615655 @default.
- W2415692417 hasConcept C41895202 @default.
- W2415692417 hasConcept C53345823 @default.
- W2415692417 hasConcept C54009773 @default.
- W2415692417 hasConcept C54355233 @default.
- W2415692417 hasConcept C55493867 @default.
- W2415692417 hasConcept C67705224 @default.
- W2415692417 hasConcept C86803240 @default.
- W2415692417 hasConcept C95444343 @default.
- W2415692417 hasConceptScore W2415692417C104317684 @default.
- W2415692417 hasConceptScore W2415692417C105580179 @default.
- W2415692417 hasConceptScore W2415692417C138885662 @default.
- W2415692417 hasConceptScore W2415692417C150194340 @default.
- W2415692417 hasConceptScore W2415692417C153911025 @default.
- W2415692417 hasConceptScore W2415692417C161733203 @default.
- W2415692417 hasConceptScore W2415692417C166703698 @default.
- W2415692417 hasConceptScore W2415692417C173396325 @default.
- W2415692417 hasConceptScore W2415692417C179926584 @default.
- W2415692417 hasConceptScore W2415692417C207001950 @default.
- W2415692417 hasConceptScore W2415692417C22615655 @default.
- W2415692417 hasConceptScore W2415692417C41895202 @default.
- W2415692417 hasConceptScore W2415692417C53345823 @default.
- W2415692417 hasConceptScore W2415692417C54009773 @default.
- W2415692417 hasConceptScore W2415692417C54355233 @default.
- W2415692417 hasConceptScore W2415692417C55493867 @default.
- W2415692417 hasConceptScore W2415692417C67705224 @default.
- W2415692417 hasConceptScore W2415692417C86803240 @default.
- W2415692417 hasConceptScore W2415692417C95444343 @default.
- W2415692417 hasLocation W24156924171 @default.
- W2415692417 hasLocation W24156924172 @default.
- W2415692417 hasOpenAccess W2415692417 @default.
- W2415692417 hasPrimaryLocation W24156924171 @default.
- W2415692417 hasRelatedWork W1963563485 @default.
- W2415692417 hasRelatedWork W1974857950 @default.
- W2415692417 hasRelatedWork W2026561311 @default.
- W2415692417 hasRelatedWork W2076785949 @default.
- W2415692417 hasRelatedWork W2093213574 @default.
- W2415692417 hasRelatedWork W2129321041 @default.
- W2415692417 hasRelatedWork W2167306613 @default.
- W2415692417 hasRelatedWork W2471583489 @default.
- W2415692417 hasRelatedWork W2810831330 @default.
- W2415692417 hasRelatedWork W2985805628 @default.
- W2415692417 isParatext "false" @default.
- W2415692417 isRetracted "false" @default.
- W2415692417 magId "2415692417" @default.
- W2415692417 workType "book-chapter" @default.