FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415694064> ?p ?o ?g. }

• W2415694064 abstract "Background Renin Angiotensin System plays a complex role in regulating physiopathologic functional and morphological modifications at vascular level. While large information exist about Angiotensin (AT) II roles, namely in the development of vascular damage under early inflammatory conditions, little is known about AT 1-7 functions, supposed to play counteracting actions vs AT II Objectives To evaluate if, in the early phases of an experimental inflammatory systemic condition namely the one induced by streptozotocin (SZ), the treatment with AT 1-7 could prevent inflammatory, pro-oxidative and structural vascular modifications, and further prevent the in vivo leukocyte trafficking activation, induced by local stimulation of well known arthritis-related proinflammatory mediators, such as thrombin (THR) or activated terminal complement complex (aTCC). Methods In compliance with European (86/609/EEC) and the Italian (D.L.116/92) rules for animal experiments, 4 groups each of 10-12 male Wistar rats were randomly grouped and treated respectively with sterile saline, or AT 1-7 (576 μg/kg/day), either in the presence or absence (healthy control group) of a preliminary standardized bolus intra vein infusion of 50mg/kg SZ. Saline and AT 1-7 were daily infused by osmotic sc minipump. After 3 weeks, in 4 anesthesized rats from each group, the occurrence of either basal, or THR or aTCC-induced local inflammatory inflammatory stimulation, stable adherence to the endothelial layer and extravasation of circulating fluorescently-labelled leukocytes were assessed at microvascular level by using an in vivo videomicroscopy technique. In the other rats, the immunohistochemical staining (IHS) and gene expression ex vivo analysis of mesentery vascular content of IL-6, MCP-1, Nitrotyrosine, connective tissue growth factor (CTGF), proliferative cell nuclear antigen (PCNA), together with structural changes, assessed by median wall:total vessel area ratio (W/TV) and extracellular matrix content, were also assessed. Results AT 1-7 did not induce any significant modification in control, healthy animals, differently AT 1-7 partly reduced the overall increase of leukocyte trafficking and extravasation in a time ranging from 15 to 60 minutes after topical exposure to THR and aTCC, while significantly inhibiting these effects (p Conclusions These data suggest that AT 1-7 could play an immune modulating role even in the earlier phases of inflammatory conditions, with prevention of secondary structural tissue alterations. This could be of relevance in the development of arthritis disease, therefore our group has recently been starting new experiments with the aim of demonstrating any AT 1-7 protective effects also in experimental arthritis Disclosure of Interest None declared" @default.
• W2415694064 created "2016-06-24" @default.
• W2415694064 creator A5004683734 @default.
• W2415694064 creator A5006648411 @default.
• W2415694064 creator A5012606835 @default.
• W2415694064 creator A5014980641 @default.
• W2415694064 creator A5040842960 @default.
• W2415694064 creator A5046695297 @default.
• W2415694064 date "2015-06-01" @default.
• W2415694064 modified "2023-09-26" @default.
• W2415694064 title "AB0062 Angiotensin 1-7 Inhibits in Vivo Leukocyte Trafficking Activation, as Well as Vascular Cytokines Expression and Vascular Structural Modifications in an Experimental Model of Chronic Inflammation. Any Potential Preventing Role Against Rheumatoid Arthritis Development?" @default.
• W2415694064 doi "https://doi.org/10.1136/annrheumdis-2015-eular.5572" @default.
• W2415694064 hasPublicationYear "2015" @default.
• W2415694064 type Work @default.
• W2415694064 sameAs 2415694064 @default.
• W2415694064 citedByCount "0" @default.
• W2415694064 crossrefType "journal-article" @default.
• W2415694064 hasAuthorship W2415694064A5004683734 @default.
• W2415694064 hasAuthorship W2415694064A5006648411 @default.
• W2415694064 hasAuthorship W2415694064A5012606835 @default.
• W2415694064 hasAuthorship W2415694064A5014980641 @default.
• W2415694064 hasAuthorship W2415694064A5040842960 @default.
• W2415694064 hasAuthorship W2415694064A5046695297 @default.
• W2415694064 hasConcept C113045295 @default.
• W2415694064 hasConcept C126322002 @default.
• W2415694064 hasConcept C134018914 @default.
• W2415694064 hasConcept C150903083 @default.
• W2415694064 hasConcept C164027704 @default.
• W2415694064 hasConcept C170493617 @default.
• W2415694064 hasConcept C17991360 @default.
• W2415694064 hasConcept C198710026 @default.
• W2415694064 hasConcept C203014093 @default.
• W2415694064 hasConcept C207001950 @default.
• W2415694064 hasConcept C24998067 @default.
• W2415694064 hasConcept C2776914184 @default.
• W2415694064 hasConcept C2777397205 @default.
• W2415694064 hasConcept C2779540182 @default.
• W2415694064 hasConcept C2908929049 @default.
• W2415694064 hasConcept C71924100 @default.
• W2415694064 hasConcept C84393581 @default.
• W2415694064 hasConcept C86803240 @default.
• W2415694064 hasConcept C98274493 @default.
• W2415694064 hasConceptScore W2415694064C113045295 @default.
• W2415694064 hasConceptScore W2415694064C126322002 @default.
• W2415694064 hasConceptScore W2415694064C134018914 @default.
• W2415694064 hasConceptScore W2415694064C150903083 @default.
• W2415694064 hasConceptScore W2415694064C164027704 @default.
• W2415694064 hasConceptScore W2415694064C170493617 @default.
• W2415694064 hasConceptScore W2415694064C17991360 @default.
• W2415694064 hasConceptScore W2415694064C198710026 @default.
• W2415694064 hasConceptScore W2415694064C203014093 @default.
• W2415694064 hasConceptScore W2415694064C207001950 @default.
• W2415694064 hasConceptScore W2415694064C24998067 @default.
• W2415694064 hasConceptScore W2415694064C2776914184 @default.
• W2415694064 hasConceptScore W2415694064C2777397205 @default.
• W2415694064 hasConceptScore W2415694064C2779540182 @default.
• W2415694064 hasConceptScore W2415694064C2908929049 @default.
• W2415694064 hasConceptScore W2415694064C71924100 @default.
• W2415694064 hasConceptScore W2415694064C84393581 @default.
• W2415694064 hasConceptScore W2415694064C86803240 @default.
• W2415694064 hasConceptScore W2415694064C98274493 @default.
• W2415694064 hasLocation W24156940641 @default.
• W2415694064 hasOpenAccess W2415694064 @default.
• W2415694064 hasPrimaryLocation W24156940641 @default.
• W2415694064 hasRelatedWork W1546186664 @default.
• W2415694064 hasRelatedWork W1972860794 @default.
• W2415694064 hasRelatedWork W1989653436 @default.
• W2415694064 hasRelatedWork W1994006394 @default.
• W2415694064 hasRelatedWork W2019057793 @default.
• W2415694064 hasRelatedWork W2022289651 @default.
• W2415694064 hasRelatedWork W2053482254 @default.
• W2415694064 hasRelatedWork W2082170144 @default.
• W2415694064 hasRelatedWork W2166777434 @default.
• W2415694064 hasRelatedWork W2227197844 @default.
• W2415694064 hasRelatedWork W2320444835 @default.
• W2415694064 hasRelatedWork W2417716256 @default.
• W2415694064 hasRelatedWork W2432599931 @default.
• W2415694064 hasRelatedWork W2606269577 @default.
• W2415694064 hasRelatedWork W2777691303 @default.
• W2415694064 hasRelatedWork W2801273031 @default.
• W2415694064 hasRelatedWork W2922395510 @default.
• W2415694064 hasRelatedWork W2944067073 @default.
• W2415694064 hasRelatedWork W2990172830 @default.
• W2415694064 hasRelatedWork W83975417 @default.
• W2415694064 isParatext "false" @default.
• W2415694064 isRetracted "false" @default.
• W2415694064 magId "2415694064" @default.
• W2415694064 workType "article" @default.