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- W2415707983 abstract "Aim: We examined the association of COMT haplotypes and plasma metabolites of catecholamines in relation to the clinical response to antipsychotics in schizophrenic and bipolar patients. Patients & methods: We studied 165 patients before and after four weeks of treatment, and 163 healthy controls. We assessed four COMT haplotypes and the plasma concentrations of HVA, DOPAC and MHPG. Results: Bipolar patients: haplotypes are associated with age at onset and clinical evolution. In schizophrenic patients, an haplotype previously associated with increased risk, is related to better response of negative symptoms. Conclusion: Haplotypes would be good indicators of the clinical status and the treatment response in bipolar and schizophrenic patients. Larger studies are required to elucidate the clinical usefulness of these findings." @default.
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- W2415707983 date "2016-06-01" @default.
- W2415707983 modified "2023-09-27" @default.
- W2415707983 title "<i>COMT</i> haplotypes, catecholamine metabolites in plasma and clinical response in schizophrenic and bipolar patients" @default.
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- W2415707983 doi "https://doi.org/10.2217/pgs-2016-0022" @default.
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