Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415749439> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2415749439 startingPage "44" @default.
- W2415749439 abstract "AIM To study the ability of recombinant protective antigen (PA) to stimulate adaptive immune response in laboratory animals. MATERIALS AND METHODS Vaccine, recombinant, and reference strains of Bacillus anthracis were used in the study. Laboratory animals were immunized subcutaneously with two doses of antigenic preparation or one dose of B. anthracis strain. After inoculation with reference strain of B. anthracis, measurement of LD50 as well as indexes of immunity was performed by specified methods. RESULTS It was revealed that asporogenic recombinant strain has stable biological characteristics during passages in vitro and is effective producer of PA. Using 2-stage chromatography, highly purified protein was obtained. Experiments on different biomodels--BALB/c mice, guinea pigs, and rabbits--demonstrated high protective activity of PA obtained from asporogenic producer. Increase of immunity index was noted when EA1 protein from S-layer was added to preparation for immunization. CONCLUSION Immunity indexes determined in experiments on laboratory animals point to high protective efficacy of recombinant PA. Further studies of its interaction with macroorganism's innate and adaptive immunity systems are promising." @default.
- W2415749439 created "2016-06-24" @default.
- W2415749439 creator A5000019196 @default.
- W2415749439 creator A5039124148 @default.
- W2415749439 creator A5042282961 @default.
- W2415749439 creator A5044069768 @default.
- W2415749439 creator A5057770375 @default.
- W2415749439 creator A5083354491 @default.
- W2415749439 date "2011-01-01" @default.
- W2415749439 modified "2023-09-24" @default.
- W2415749439 title "Immunogenicity of protective antigen extracted from asporogenic recombinant strain Bacillus anthracis" @default.
- W2415749439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21446166" @default.
- W2415749439 hasPublicationYear "2011" @default.
- W2415749439 type Work @default.
- W2415749439 sameAs 2415749439 @default.
- W2415749439 citedByCount "1" @default.
- W2415749439 countsByYear W24157494392014 @default.
- W2415749439 crossrefType "journal-article" @default.
- W2415749439 hasAuthorship W2415749439A5000019196 @default.
- W2415749439 hasAuthorship W2415749439A5039124148 @default.
- W2415749439 hasAuthorship W2415749439A5042282961 @default.
- W2415749439 hasAuthorship W2415749439A5044069768 @default.
- W2415749439 hasAuthorship W2415749439A5057770375 @default.
- W2415749439 hasAuthorship W2415749439A5083354491 @default.
- W2415749439 hasConcept C104317684 @default.
- W2415749439 hasConcept C105702510 @default.
- W2415749439 hasConcept C136449434 @default.
- W2415749439 hasConcept C147483822 @default.
- W2415749439 hasConcept C159047783 @default.
- W2415749439 hasConcept C167508917 @default.
- W2415749439 hasConcept C193419808 @default.
- W2415749439 hasConcept C203014093 @default.
- W2415749439 hasConcept C2777289321 @default.
- W2415749439 hasConcept C2778022156 @default.
- W2415749439 hasConcept C2779341262 @default.
- W2415749439 hasConcept C2780239966 @default.
- W2415749439 hasConcept C2780801004 @default.
- W2415749439 hasConcept C2780868878 @default.
- W2415749439 hasConcept C40767141 @default.
- W2415749439 hasConcept C523546767 @default.
- W2415749439 hasConcept C54355233 @default.
- W2415749439 hasConcept C55493867 @default.
- W2415749439 hasConcept C86803240 @default.
- W2415749439 hasConcept C8891405 @default.
- W2415749439 hasConcept C89423630 @default.
- W2415749439 hasConceptScore W2415749439C104317684 @default.
- W2415749439 hasConceptScore W2415749439C105702510 @default.
- W2415749439 hasConceptScore W2415749439C136449434 @default.
- W2415749439 hasConceptScore W2415749439C147483822 @default.
- W2415749439 hasConceptScore W2415749439C159047783 @default.
- W2415749439 hasConceptScore W2415749439C167508917 @default.
- W2415749439 hasConceptScore W2415749439C193419808 @default.
- W2415749439 hasConceptScore W2415749439C203014093 @default.
- W2415749439 hasConceptScore W2415749439C2777289321 @default.
- W2415749439 hasConceptScore W2415749439C2778022156 @default.
- W2415749439 hasConceptScore W2415749439C2779341262 @default.
- W2415749439 hasConceptScore W2415749439C2780239966 @default.
- W2415749439 hasConceptScore W2415749439C2780801004 @default.
- W2415749439 hasConceptScore W2415749439C2780868878 @default.
- W2415749439 hasConceptScore W2415749439C40767141 @default.
- W2415749439 hasConceptScore W2415749439C523546767 @default.
- W2415749439 hasConceptScore W2415749439C54355233 @default.
- W2415749439 hasConceptScore W2415749439C55493867 @default.
- W2415749439 hasConceptScore W2415749439C86803240 @default.
- W2415749439 hasConceptScore W2415749439C8891405 @default.
- W2415749439 hasConceptScore W2415749439C89423630 @default.
- W2415749439 hasIssue "1" @default.
- W2415749439 hasLocation W24157494391 @default.
- W2415749439 hasLocation W24157494392 @default.
- W2415749439 hasOpenAccess W2415749439 @default.
- W2415749439 hasPrimaryLocation W24157494391 @default.
- W2415749439 hasRelatedWork W111650244 @default.
- W2415749439 hasRelatedWork W1560132224 @default.
- W2415749439 hasRelatedWork W1942311922 @default.
- W2415749439 hasRelatedWork W1950485857 @default.
- W2415749439 hasRelatedWork W1966924859 @default.
- W2415749439 hasRelatedWork W1996422133 @default.
- W2415749439 hasRelatedWork W1997833744 @default.
- W2415749439 hasRelatedWork W2029821093 @default.
- W2415749439 hasRelatedWork W2064660148 @default.
- W2415749439 hasRelatedWork W2079152401 @default.
- W2415749439 hasRelatedWork W2104865698 @default.
- W2415749439 hasRelatedWork W2128244681 @default.
- W2415749439 hasRelatedWork W2133016843 @default.
- W2415749439 hasRelatedWork W2137372488 @default.
- W2415749439 hasRelatedWork W2143232163 @default.
- W2415749439 hasRelatedWork W2156164994 @default.
- W2415749439 hasRelatedWork W2918020043 @default.
- W2415749439 hasRelatedWork W2969088210 @default.
- W2415749439 hasRelatedWork W3130445001 @default.
- W2415749439 hasRelatedWork W273474840 @default.
- W2415749439 isParatext "false" @default.
- W2415749439 isRetracted "false" @default.
- W2415749439 magId "2415749439" @default.
- W2415749439 workType "article" @default.