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- W2415785838 startingPage "748" @default.
- W2415785838 abstract "Pancreatic ductal adenocarcinoma (PDAC) is an almost uniformly lethal disease with less than 5% survival at five years. This is largely due to metastatic disease, which is already present in the majority of patients when diagnosed. Even when the primary cancer can be removed by radical surgery, local recurrence occurs within one year in 50%-80% of cases. Therefore, it is imperative to develop new approaches for the treatment of advanced cancer and the prevention of recurrence after surgery. Tumour-targeted oncolytic viruses (TOVs) have become an attractive therapeutic agent as TOVs can kill cancer cells through multiple mechanisms of action, especially via virus-induced engagement of the immune response specifically against tumour cells. To attack tumour cells effectively, tumour-specific T cells need to overcome negative regulatory signals that suppress their activation or that induce tolerance programmes such as anergy or exhaustion in the tumour microenvironment. In this regard, the recent breakthrough in immunotherapy achieved with immune checkpoint blockade agents, such as anti-cytotoxic T-lymphocyte-associate protein 4, programmed death 1 (PD-1) or PD-L1 antibodies, has demonstrated the possibility of relieving immune suppression in PDAC. Therefore, the combination of oncolytic virotherapy and immune checkpoint blockade agents may synergistically function to enhance the antitumour response, lending the opportunity to be the future for treatment of pancreatic cancer." @default.
- W2415785838 created "2016-06-24" @default.
- W2415785838 creator A5051547964 @default.
- W2415785838 creator A5079279782 @default.
- W2415785838 date "2016-01-01" @default.
- W2415785838 modified "2023-10-16" @default.
- W2415785838 title "Viro-immune therapy: A new strategy for treatment of pancreatic cancer" @default.
- W2415785838 cites W109492528 @default.
- W2415785838 cites W1491631791 @default.
- W2415785838 cites W1504049064 @default.
- W2415785838 cites W1549566105 @default.
- W2415785838 cites W1565005755 @default.
- W2415785838 cites W1616217811 @default.
- W2415785838 cites W1727989948 @default.
- W2415785838 cites W1730409572 @default.
- W2415785838 cites W1730695993 @default.
- W2415785838 cites W1875592451 @default.
- W2415785838 cites W1931508686 @default.
- W2415785838 cites W1966263947 @default.
- W2415785838 cites W1966648901 @default.
- W2415785838 cites W1970060539 @default.
- W2415785838 cites W1972399933 @default.
- W2415785838 cites W1974922522 @default.
- W2415785838 cites W1979183610 @default.
- W2415785838 cites W1980351032 @default.
- W2415785838 cites W1980973208 @default.
- W2415785838 cites W1988065950 @default.
- W2415785838 cites W1989525286 @default.
- W2415785838 cites W1991148746 @default.
- W2415785838 cites W1991189369 @default.
- W2415785838 cites W1994177577 @default.
- W2415785838 cites W1999102084 @default.
- W2415785838 cites W2000114190 @default.
- W2415785838 cites W2000138369 @default.
- W2415785838 cites W2001248362 @default.
- W2415785838 cites W2002250199 @default.
- W2415785838 cites W2004630197 @default.
- W2415785838 cites W2004832984 @default.
- W2415785838 cites W2005067757 @default.
- W2415785838 cites W2009048972 @default.
- W2415785838 cites W2009801072 @default.
- W2415785838 cites W2010121426 @default.
- W2415785838 cites W2010340952 @default.
- W2415785838 cites W2011513757 @default.
- W2415785838 cites W2011982648 @default.
- W2415785838 cites W2012055729 @default.
- W2415785838 cites W2013090484 @default.
- W2415785838 cites W2015118124 @default.
- W2415785838 cites W2016356298 @default.
- W2415785838 cites W2016732129 @default.
- W2415785838 cites W2016789384 @default.
- W2415785838 cites W2016983859 @default.
- W2415785838 cites W2020189113 @default.
- W2415785838 cites W2022299158 @default.
- W2415785838 cites W2024411676 @default.
- W2415785838 cites W2025163778 @default.
- W2415785838 cites W2029484718 @default.
- W2415785838 cites W2029765161 @default.
- W2415785838 cites W2030494738 @default.
- W2415785838 cites W2031960993 @default.
- W2415785838 cites W2032229065 @default.
- W2415785838 cites W2033299041 @default.
- W2415785838 cites W2038914273 @default.
- W2415785838 cites W2043991982 @default.
- W2415785838 cites W2044363258 @default.
- W2415785838 cites W2044567178 @default.
- W2415785838 cites W2044835625 @default.
- W2415785838 cites W2047318784 @default.
- W2415785838 cites W2047847988 @default.
- W2415785838 cites W2049078823 @default.
- W2415785838 cites W2051745673 @default.
- W2415785838 cites W2052705131 @default.
- W2415785838 cites W2054373401 @default.
- W2415785838 cites W2054797383 @default.
- W2415785838 cites W2056221241 @default.
- W2415785838 cites W2056459029 @default.
- W2415785838 cites W2057893793 @default.
- W2415785838 cites W2062994475 @default.
- W2415785838 cites W2063264144 @default.
- W2415785838 cites W2063512646 @default.
- W2415785838 cites W2066671159 @default.
- W2415785838 cites W2070248644 @default.
- W2415785838 cites W2071260213 @default.
- W2415785838 cites W2071462987 @default.
- W2415785838 cites W2071758752 @default.
- W2415785838 cites W2073134590 @default.
- W2415785838 cites W2073525113 @default.
- W2415785838 cites W2073768319 @default.
- W2415785838 cites W2076067786 @default.
- W2415785838 cites W2078854426 @default.
- W2415785838 cites W2079018735 @default.
- W2415785838 cites W2079548788 @default.
- W2415785838 cites W2079647238 @default.
- W2415785838 cites W2080862712 @default.
- W2415785838 cites W2080878900 @default.
- W2415785838 cites W2080954686 @default.
- W2415785838 cites W2081183739 @default.
- W2415785838 cites W2081188511 @default.