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- W2415820963 abstract "Herein we report an in vitro kinetic evaluation against the most relevant human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms (I, II, IX and XII) of a small series of lactate dehydrogenase (LDH, EC 1.1.1.27) inhibitors. All compounds contain a primary sulfonamide zinc-binding group (ZBG) substituted with the 2-thio-6-oxo-1,6-dihydropyrimidine scaffold. By means of X-ray crystallographic experiments we explored the ligand–enzyme binding modes, thus highlighting the contribution of the 2-thio-6-oxo-1,6-dihydropyrimidine moiety to the stabilization of the complex." @default.
- W2415820963 created "2016-06-24" @default.
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- W2415820963 date "2016-08-01" @default.
- W2415820963 modified "2023-09-26" @default.
- W2415820963 title "Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine–benzenesulfonamides acting as carbonic anhydrase inhibitors" @default.
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- W2415820963 doi "https://doi.org/10.1016/j.bmc.2016.06.005" @default.
- W2415820963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27316543" @default.
- W2415820963 hasPublicationYear "2016" @default.
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