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- W2415850696 endingPage "1244" @default.
- W2415850696 startingPage "1235" @default.
- W2415850696 abstract "In pediatric pharmacotherapy, many drugs are still used off-label, and their efficacy and safety is not well characterized. Different efficacy and safety profiles in children of varying ages may be anticipated, due to developmental changes occurring across pediatric life.Beside pharmacokinetic (PK) studies, pharmacodynamic (PD) studies are urgently needed. Validated PKPD models can be used to derive optimal dosing regimens for children of different ages, which can be evaluated in a prospective study before implementation in clinical practice. Strategies should be developed to ensure that formularies update their drug dosing guidelines regularly according to the most recent advances in research, allowing for clinicians to integrate these guidelines in daily practice. Expert commentary: We anticipate a trend towards a systems-level approach in pediatric modeling to optimally use the information gained in pediatric trials. For this approach, properly designed clinical PKPD studies will remain the backbone of pediatric research." @default.
- W2415850696 created "2016-06-24" @default.
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- W2415850696 date "2016-06-27" @default.
- W2415850696 modified "2023-10-16" @default.
- W2415850696 title "Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling" @default.
- W2415850696 cites W1255114565 @default.
- W2415850696 cites W135147496 @default.
- W2415850696 cites W1492009410 @default.
- W2415850696 cites W1496317234 @default.
- W2415850696 cites W1512575153 @default.
- W2415850696 cites W1542069658 @default.
- W2415850696 cites W1586007261 @default.
- W2415850696 cites W1776260563 @default.
- W2415850696 cites W1785847611 @default.
- W2415850696 cites W1831893120 @default.
- W2415850696 cites W1869003428 @default.
- W2415850696 cites W1884274622 @default.
- W2415850696 cites W1949023840 @default.
- W2415850696 cites W1957349123 @default.
- W2415850696 cites W1960114065 @default.
- W2415850696 cites W1965800076 @default.
- W2415850696 cites W1966210201 @default.
- W2415850696 cites W1970580273 @default.
- W2415850696 cites W1976959601 @default.
- W2415850696 cites W1978867369 @default.
- W2415850696 cites W1983033150 @default.
- W2415850696 cites W1986267161 @default.
- W2415850696 cites W1990647320 @default.
- W2415850696 cites W1991510925 @default.
- W2415850696 cites W2002576711 @default.
- W2415850696 cites W2007429051 @default.
- W2415850696 cites W2008138572 @default.
- W2415850696 cites W2010272667 @default.
- W2415850696 cites W2014341375 @default.
- W2415850696 cites W2015796769 @default.
- W2415850696 cites W2020365240 @default.
- W2415850696 cites W2021872392 @default.
- W2415850696 cites W2026243710 @default.
- W2415850696 cites W2030872971 @default.
- W2415850696 cites W2031426306 @default.
- W2415850696 cites W2045883317 @default.
- W2415850696 cites W2047820725 @default.
- W2415850696 cites W2048973207 @default.
- W2415850696 cites W2050005887 @default.
- W2415850696 cites W2055371712 @default.
- W2415850696 cites W2056455169 @default.
- W2415850696 cites W2056461987 @default.
- W2415850696 cites W2058734479 @default.
- W2415850696 cites W2061444633 @default.
- W2415850696 cites W2065308091 @default.
- W2415850696 cites W2066543180 @default.
- W2415850696 cites W2070013574 @default.
- W2415850696 cites W2073909589 @default.
- W2415850696 cites W2074024224 @default.
- W2415850696 cites W2075131386 @default.
- W2415850696 cites W2075435606 @default.
- W2415850696 cites W2075643141 @default.
- W2415850696 cites W2076736267 @default.
- W2415850696 cites W2077053481 @default.
- W2415850696 cites W2080549781 @default.
- W2415850696 cites W2083407969 @default.
- W2415850696 cites W2083668821 @default.
- W2415850696 cites W2085646040 @default.
- W2415850696 cites W2087723398 @default.
- W2415850696 cites W2088379477 @default.
- W2415850696 cites W2088996598 @default.
- W2415850696 cites W2092667376 @default.
- W2415850696 cites W2094019929 @default.
- W2415850696 cites W2098891765 @default.
- W2415850696 cites W2105040789 @default.
- W2415850696 cites W2111615344 @default.
- W2415850696 cites W2115571073 @default.
- W2415850696 cites W2117089529 @default.
- W2415850696 cites W2120725688 @default.
- W2415850696 cites W2122527560 @default.
- W2415850696 cites W2127547864 @default.
- W2415850696 cites W2127907758 @default.
- W2415850696 cites W2133410671 @default.
- W2415850696 cites W2136969177 @default.
- W2415850696 cites W2140160810 @default.
- W2415850696 cites W2140604471 @default.
- W2415850696 cites W2144360986 @default.
- W2415850696 cites W2148148407 @default.
- W2415850696 cites W2151470521 @default.
- W2415850696 cites W2152100394 @default.
- W2415850696 cites W2159764323 @default.
- W2415850696 cites W2163200222 @default.
- W2415850696 cites W2171233963 @default.
- W2415850696 cites W2171642196 @default.
- W2415850696 cites W2218056009 @default.
- W2415850696 cites W2234303651 @default.