Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415882309> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2415882309 endingPage "8" @default.
- W2415882309 startingPage "761" @default.
- W2415882309 abstract "In order to estimate the effects of methylprednisolone pulse therapy on progressive IgA nephropathy, clinical parameters in eight patients with the disease were compared between before and after the therapy. In this study progressive IgA nephropathy was defined as follows; 24 hour urinary protein excretion was (++) or more and renal biopsy carried out just before the therapy revealed crescents, inevitably including cellular crescents, in 10% or more glomeruli observed. Methylprednisolone 1000 mg a day was intravenously administered for three consecutive days and the therapy was repeated with an interval of 4 days. The additional third course was given in two patients, in whom significant decrease in urinary protein had not been obtained after the original two courses of the therapy. Oral prednisolone 20 mg a day started simultaneously was tapered one month later to maintenance daily doses of 5-10 mg. After the pulse therapy urinary protein excretion was significantly decreased in every patient with a mean decrease from 2.3 +/- 0.5 (0.8-5.5)g to 1.1 +/- 0.3 (0-2.8)g (p less than 0.05). Glomerular filtration rate (GFR) was increased from 83 +/- 11 (31-115) ml/min to 96 +/- 10 (44-130) ml/min (p less than 0.05). In the initial biopsy crescents were observed in 25 +/- 7 (19-57)% of glomeruli observed and 20-100% of these were composed of cellular crescents. Complete loss of cellular crescents in 6 patients and a marked decrease from 73% to 33% in another were demonstrated by the second biopsies performed after the pulse therapy. These results suggested that the methylprednisolone pulse therapy significantly reduced urinary protein excretion and improved renal function through suppression of new crescent formation as well as transformation of cellular crescents to fibrocellular or fibrous crescents." @default.
- W2415882309 created "2016-06-24" @default.
- W2415882309 creator A5004036017 @default.
- W2415882309 creator A5010496747 @default.
- W2415882309 creator A5049595202 @default.
- W2415882309 creator A5066956159 @default.
- W2415882309 creator A5083314150 @default.
- W2415882309 date "1991-08-01" @default.
- W2415882309 modified "2023-09-24" @default.
- W2415882309 title "[Effects of methylprednisolone pulse therapy on progressive IgA nephropathy]." @default.
- W2415882309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1770636" @default.
- W2415882309 hasPublicationYear "1991" @default.
- W2415882309 type Work @default.
- W2415882309 sameAs 2415882309 @default.
- W2415882309 citedByCount "2" @default.
- W2415882309 crossrefType "journal-article" @default.
- W2415882309 hasAuthorship W2415882309A5004036017 @default.
- W2415882309 hasAuthorship W2415882309A5010496747 @default.
- W2415882309 hasAuthorship W2415882309A5049595202 @default.
- W2415882309 hasAuthorship W2415882309A5066956159 @default.
- W2415882309 hasAuthorship W2415882309A5083314150 @default.
- W2415882309 hasConcept C10146269 @default.
- W2415882309 hasConcept C126322002 @default.
- W2415882309 hasConcept C126894567 @default.
- W2415882309 hasConcept C134018914 @default.
- W2415882309 hasConcept C159641895 @default.
- W2415882309 hasConcept C2775934546 @default.
- W2415882309 hasConcept C2775998817 @default.
- W2415882309 hasConcept C2776715498 @default.
- W2415882309 hasConcept C2779561371 @default.
- W2415882309 hasConcept C2780091579 @default.
- W2415882309 hasConcept C2780306776 @default.
- W2415882309 hasConcept C2780368995 @default.
- W2415882309 hasConcept C2780372218 @default.
- W2415882309 hasConcept C2781087799 @default.
- W2415882309 hasConcept C2781184683 @default.
- W2415882309 hasConcept C555293320 @default.
- W2415882309 hasConcept C71924100 @default.
- W2415882309 hasConcept C77411442 @default.
- W2415882309 hasConcept C90924648 @default.
- W2415882309 hasConceptScore W2415882309C10146269 @default.
- W2415882309 hasConceptScore W2415882309C126322002 @default.
- W2415882309 hasConceptScore W2415882309C126894567 @default.
- W2415882309 hasConceptScore W2415882309C134018914 @default.
- W2415882309 hasConceptScore W2415882309C159641895 @default.
- W2415882309 hasConceptScore W2415882309C2775934546 @default.
- W2415882309 hasConceptScore W2415882309C2775998817 @default.
- W2415882309 hasConceptScore W2415882309C2776715498 @default.
- W2415882309 hasConceptScore W2415882309C2779561371 @default.
- W2415882309 hasConceptScore W2415882309C2780091579 @default.
- W2415882309 hasConceptScore W2415882309C2780306776 @default.
- W2415882309 hasConceptScore W2415882309C2780368995 @default.
- W2415882309 hasConceptScore W2415882309C2780372218 @default.
- W2415882309 hasConceptScore W2415882309C2781087799 @default.
- W2415882309 hasConceptScore W2415882309C2781184683 @default.
- W2415882309 hasConceptScore W2415882309C555293320 @default.
- W2415882309 hasConceptScore W2415882309C71924100 @default.
- W2415882309 hasConceptScore W2415882309C77411442 @default.
- W2415882309 hasConceptScore W2415882309C90924648 @default.
- W2415882309 hasIssue "8" @default.
- W2415882309 hasLocation W24158823091 @default.
- W2415882309 hasOpenAccess W2415882309 @default.
- W2415882309 hasPrimaryLocation W24158823091 @default.
- W2415882309 hasRelatedWork W1975166147 @default.
- W2415882309 hasRelatedWork W2034670675 @default.
- W2415882309 hasRelatedWork W2183084692 @default.
- W2415882309 hasRelatedWork W2211317287 @default.
- W2415882309 hasRelatedWork W2380303926 @default.
- W2415882309 hasRelatedWork W2391246432 @default.
- W2415882309 hasRelatedWork W2415882309 @default.
- W2415882309 hasRelatedWork W3160593593 @default.
- W2415882309 hasRelatedWork W4229041314 @default.
- W2415882309 hasRelatedWork W197106387 @default.
- W2415882309 hasVolume "33" @default.
- W2415882309 isParatext "false" @default.
- W2415882309 isRetracted "false" @default.
- W2415882309 magId "2415882309" @default.
- W2415882309 workType "article" @default.