Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415889503> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2415889503 endingPage "92" @default.
- W2415889503 startingPage "89" @default.
- W2415889503 abstract "Immune tolerance to the fetus is predetermined mainly by HLA-G expression in trophoblasts, varying the ratio of Th1 / Th2, decrease in the content of cytotoxic T lymphocytes and natural killer cells (NK cells) and fusion tread of antibodies. The aim of the study was to establish the role of the placental hypoxia in regulation of expression of -lymphocytes populations in the blood of rats at different stages of pregnancy. For the purpose of modeling of PE in pregnant rats, at10-th day of gestation the lumen of the abdominal aorta below the renal artery was narrowed by the silk thread a third of its diameter (0.2 mm). In blood serum was defined the relative content of leukocyte subpopulations by indirect immunofluorescence in cytotoxic assay using monoclonal antibodies to CD4, CD8, CD14, CD16 leukocytes («ICN Pharmaceutical», USA). The study found that in the blood of animals of control group (phisiological pregnancy) within the 2nd 3rd trimester of gestation of CD4, CD8 subpopulations of lymphocytes did not change. The animals of the experimental group (pregnancy complicated by placental hypoxia) content of CD8 subpopulations and CD16 (NK cells) in the blood did not change significantly compared with those in the blood of animals in the control group, whereas CD4 T cell subpopulation in the second and in the third trimester statistical significantly decreased compared with those in control group (p<0.001). The ratio of immunoregulatory subpopulations lymphocytes CD4/CD8 decreased, number of CD14 (monocytes) phenotypes leukocytes increased. It is concluded that the placental hypoxia promotes disorder of the regulation of the immune balance of the mother's body during pregnancy, which is manifested in decrease ratio immunoregulatory subpopulations of lymphocyte, increasing the intensity of local expression of monocytes." @default.
- W2415889503 created "2016-06-24" @default.
- W2415889503 creator A5012780965 @default.
- W2415889503 creator A5046220834 @default.
- W2415889503 creator A5067857880 @default.
- W2415889503 date "2015-04-01" @default.
- W2415889503 modified "2023-09-23" @default.
- W2415889503 title "[Alterations in populations of T-lymphocytes in the rats blood during experimental preeclampsia]." @default.
- W2415889503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25953947" @default.
- W2415889503 hasPublicationYear "2015" @default.
- W2415889503 type Work @default.
- W2415889503 sameAs 2415889503 @default.
- W2415889503 citedByCount "0" @default.
- W2415889503 crossrefType "journal-article" @default.
- W2415889503 hasAuthorship W2415889503A5012780965 @default.
- W2415889503 hasAuthorship W2415889503A5046220834 @default.
- W2415889503 hasAuthorship W2415889503A5067857880 @default.
- W2415889503 hasConcept C114684123 @default.
- W2415889503 hasConcept C126322002 @default.
- W2415889503 hasConcept C134018914 @default.
- W2415889503 hasConcept C154317977 @default.
- W2415889503 hasConcept C16685009 @default.
- W2415889503 hasConcept C167672396 @default.
- W2415889503 hasConcept C172680121 @default.
- W2415889503 hasConcept C202751555 @default.
- W2415889503 hasConcept C203014093 @default.
- W2415889503 hasConcept C2777218350 @default.
- W2415889503 hasConcept C2778102761 @default.
- W2415889503 hasConcept C2778513237 @default.
- W2415889503 hasConcept C2779234561 @default.
- W2415889503 hasConcept C2780914630 @default.
- W2415889503 hasConcept C2781462264 @default.
- W2415889503 hasConcept C54355233 @default.
- W2415889503 hasConcept C55493867 @default.
- W2415889503 hasConcept C71924100 @default.
- W2415889503 hasConcept C86803240 @default.
- W2415889503 hasConcept C8891405 @default.
- W2415889503 hasConceptScore W2415889503C114684123 @default.
- W2415889503 hasConceptScore W2415889503C126322002 @default.
- W2415889503 hasConceptScore W2415889503C134018914 @default.
- W2415889503 hasConceptScore W2415889503C154317977 @default.
- W2415889503 hasConceptScore W2415889503C16685009 @default.
- W2415889503 hasConceptScore W2415889503C167672396 @default.
- W2415889503 hasConceptScore W2415889503C172680121 @default.
- W2415889503 hasConceptScore W2415889503C202751555 @default.
- W2415889503 hasConceptScore W2415889503C203014093 @default.
- W2415889503 hasConceptScore W2415889503C2777218350 @default.
- W2415889503 hasConceptScore W2415889503C2778102761 @default.
- W2415889503 hasConceptScore W2415889503C2778513237 @default.
- W2415889503 hasConceptScore W2415889503C2779234561 @default.
- W2415889503 hasConceptScore W2415889503C2780914630 @default.
- W2415889503 hasConceptScore W2415889503C2781462264 @default.
- W2415889503 hasConceptScore W2415889503C54355233 @default.
- W2415889503 hasConceptScore W2415889503C55493867 @default.
- W2415889503 hasConceptScore W2415889503C71924100 @default.
- W2415889503 hasConceptScore W2415889503C86803240 @default.
- W2415889503 hasConceptScore W2415889503C8891405 @default.
- W2415889503 hasIssue "241" @default.
- W2415889503 hasLocation W24158895031 @default.
- W2415889503 hasOpenAccess W2415889503 @default.
- W2415889503 hasPrimaryLocation W24158895031 @default.
- W2415889503 hasRelatedWork W1196912039 @default.
- W2415889503 hasRelatedWork W1981184132 @default.
- W2415889503 hasRelatedWork W2018916009 @default.
- W2415889503 hasRelatedWork W2051727352 @default.
- W2415889503 hasRelatedWork W2065169027 @default.
- W2415889503 hasRelatedWork W2428931658 @default.
- W2415889503 hasRelatedWork W2918373185 @default.
- W2415889503 hasRelatedWork W2946086048 @default.
- W2415889503 hasRelatedWork W3116414021 @default.
- W2415889503 hasRelatedWork W4210497221 @default.
- W2415889503 isParatext "false" @default.
- W2415889503 isRetracted "false" @default.
- W2415889503 magId "2415889503" @default.
- W2415889503 workType "article" @default.