FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415909923> ?p ?o ?g. }

• W2415909923 endingPage "C277" @default.
• W2415909923 startingPage "C271" @default.
• W2415909923 abstract "The rate of decline of free intracellular Ca concentration ([Ca]i) is a potentially useful index of the function of Ca transport systems. However, interpretations of these results may depend on multiple Ca transport systems and interaction with intracellular Ca binding sites. We measured [Ca]i in voltage-clamped ventricular myocytes isolated from rat hearts using indo 1 fluorescence. Conditions were chosen where [Ca]i decline was expected to depend almost exclusively on the sarcoplasmic reticulum Ca pump. The half time of [Ca]i decline (t1/2) decreased as the amplitude of the intracellular Ca (Cai) transient increased. This is not the result that would be expected from a transport system where the transport rate is a linear function of free [Ca]i. In this case the time constant of [Ca]i decline (tau) should be independent of the peak value of [Ca]i. This is also true if linear buffering of Cai is included. We develop a simple but more realistic theoretical framework where Ca transport rate and Ca binding both depend on free [Ca]i with Michaelis-Menten type functions. We demonstrate that the observed decline in apparent tau with increasing peak [Ca]i is entirely expected on theoretical grounds and over a wide range of characteristics for Ca transport and binding. We conclude that one cannot draw inferences about the intrinsic Ca transport function based on tau values unless the Cai transient has a comparable size." @default.
• W2415909923 created "2016-06-24" @default.
• W2415909923 creator A5020824899 @default.
• W2415909923 creator A5084889241 @default.
• W2415909923 date "1995-01-01" @default.
• W2415909923 modified "2023-09-30" @default.
• W2415909923 title "Kinetics of [Ca]i decline in cardiac myocytes depend on peak [Ca]i" @default.
• W2415909923 cites W1997189849 @default.
• W2415909923 cites W1999132987 @default.
• W2415909923 cites W2015122100 @default.
• W2415909923 cites W2020232993 @default.
• W2415909923 cites W2042646075 @default.
• W2415909923 cites W2045191889 @default.
• W2415909923 cites W2050551491 @default.
• W2415909923 cites W2066324356 @default.
• W2415909923 cites W2070441180 @default.
• W2415909923 cites W2072642864 @default.
• W2415909923 cites W2082408192 @default.
• W2415909923 cites W2091923659 @default.
• W2415909923 cites W2093330924 @default.
• W2415909923 cites W2101489177 @default.
• W2415909923 cites W2141260882 @default.
• W2415909923 cites W2158600536 @default.
• W2415909923 cites W2164931274 @default.
• W2415909923 cites W2165286550 @default.
• W2415909923 doi "https://doi.org/10.1152/ajpcell.1995.268.1.c271" @default.
• W2415909923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7840156" @default.
• W2415909923 hasPublicationYear "1995" @default.
• W2415909923 type Work @default.
• W2415909923 sameAs 2415909923 @default.
• W2415909923 citedByCount "119" @default.
• W2415909923 countsByYear W24159099232012 @default.
• W2415909923 countsByYear W24159099232013 @default.
• W2415909923 countsByYear W24159099232014 @default.
• W2415909923 countsByYear W24159099232015 @default.
• W2415909923 countsByYear W24159099232016 @default.
• W2415909923 countsByYear W24159099232018 @default.
• W2415909923 countsByYear W24159099232020 @default.
• W2415909923 countsByYear W24159099232021 @default.
• W2415909923 countsByYear W24159099232022 @default.
• W2415909923 countsByYear W24159099232023 @default.
• W2415909923 crossrefType "journal-article" @default.
• W2415909923 hasAuthorship W2415909923A5020824899 @default.
• W2415909923 hasAuthorship W2415909923A5084889241 @default.
• W2415909923 hasConcept C113196181 @default.
• W2415909923 hasConcept C121332964 @default.
• W2415909923 hasConcept C12554922 @default.
• W2415909923 hasConcept C134018914 @default.
• W2415909923 hasConcept C14036430 @default.
• W2415909923 hasConcept C145148216 @default.
• W2415909923 hasConcept C148898269 @default.
• W2415909923 hasConcept C158617107 @default.
• W2415909923 hasConcept C178790620 @default.
• W2415909923 hasConcept C185592680 @default.
• W2415909923 hasConcept C207200792 @default.
• W2415909923 hasConcept C43617362 @default.
• W2415909923 hasConcept C519063684 @default.
• W2415909923 hasConcept C55493867 @default.
• W2415909923 hasConcept C62520636 @default.
• W2415909923 hasConcept C79879829 @default.
• W2415909923 hasConcept C86803240 @default.
• W2415909923 hasConcept C95444343 @default.
• W2415909923 hasConcept C99975950 @default.
• W2415909923 hasConceptScore W2415909923C113196181 @default.
• W2415909923 hasConceptScore W2415909923C121332964 @default.
• W2415909923 hasConceptScore W2415909923C12554922 @default.
• W2415909923 hasConceptScore W2415909923C134018914 @default.
• W2415909923 hasConceptScore W2415909923C14036430 @default.
• W2415909923 hasConceptScore W2415909923C145148216 @default.
• W2415909923 hasConceptScore W2415909923C148898269 @default.
• W2415909923 hasConceptScore W2415909923C158617107 @default.
• W2415909923 hasConceptScore W2415909923C178790620 @default.
• W2415909923 hasConceptScore W2415909923C185592680 @default.
• W2415909923 hasConceptScore W2415909923C207200792 @default.
• W2415909923 hasConceptScore W2415909923C43617362 @default.
• W2415909923 hasConceptScore W2415909923C519063684 @default.
• W2415909923 hasConceptScore W2415909923C55493867 @default.
• W2415909923 hasConceptScore W2415909923C62520636 @default.
• W2415909923 hasConceptScore W2415909923C79879829 @default.
• W2415909923 hasConceptScore W2415909923C86803240 @default.
• W2415909923 hasConceptScore W2415909923C95444343 @default.
• W2415909923 hasConceptScore W2415909923C99975950 @default.
• W2415909923 hasIssue "1" @default.
• W2415909923 hasLocation W24159099231 @default.
• W2415909923 hasLocation W24159099232 @default.
• W2415909923 hasOpenAccess W2415909923 @default.
• W2415909923 hasPrimaryLocation W24159099231 @default.
• W2415909923 hasRelatedWork W1125192232 @default.
• W2415909923 hasRelatedWork W154292401 @default.
• W2415909923 hasRelatedWork W2010740725 @default.
• W2415909923 hasRelatedWork W2042342600 @default.
• W2415909923 hasRelatedWork W2089232336 @default.
• W2415909923 hasRelatedWork W2092476470 @default.
• W2415909923 hasRelatedWork W2167100798 @default.
• W2415909923 hasRelatedWork W2337785167 @default.
• W2415909923 hasRelatedWork W2384457103 @default.
• W2415909923 hasRelatedWork W3151887034 @default.
• W2415909923 hasVolume "268" @default.

• next