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- W2415914319 abstract "A shift of the delicate balance between apoptosis and survival-inducing signals determines the fate of neurons during the development of the central nervous system and its homeostasis throughout adulthood. Both pathways, promoting or protecting from apoptosis, trigger a transcriptional program. We conducted whole-genome expression profiling to decipher the transcriptional regulatory elements controlling the apoptotic/survival switch in cerebellar granule neurons following the induction of apoptosis by serum and potassium deprivation or their rescue by either insulin-like growth factor-1 (Igf1) or pituitary adenylyl cyclase-activating polypeptide (Pacap). Although depending on different upstream signaling pathways, the survival effects of Igf1 and Pacap converged into common transcriptional cascades, thus suggesting the existence of a general transcriptional program underlying neuronal survival." @default.
- W2415914319 created "2016-06-24" @default.
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- W2415914319 date "2015-09-07" @default.
- W2415914319 modified "2023-10-15" @default.
- W2415914319 title "Igf1 and Pacap rescue cerebellar granule neurons from apoptosis via a common transcriptional program" @default.
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- W2415914319 doi "https://doi.org/10.1038/cddiscovery.2015.29" @default.
- W2415914319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773033" @default.
- W2415914319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26941962" @default.
- W2415914319 hasPublicationYear "2015" @default.
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