FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2415915087> ?p ?o ?g. }

• W2415915087 abstract "Papanicolaou testing has been held as the gold standard of screening programs as it is capable of detecting early, curable disease. This is true, as the microscopic evaluation of exfoliated cells or those obtained by a spatula does lead to lives saved; mortality rates from cervical cancer have plummeted where it has been introduced—for example, by 70% in the United States over the past 60 years.However, the age at onset of screening, its frequency, the age at stopping screening, and cotesting with human papillomavirus (HPV) DNA have all come under review as the pathology of cervical cancer has become better understood. The role of HPV as a causative agent when recurrently present has stimulated changes in approaches from primary prevention through vaccination, to various recommendations concerning Papanicolaou and HPV DNA testing. The screening programs of 10 years ago are no longer evidence based and will undoubtedly change as more data about HPV-vaccinated women become available. So what are the current recommendations for screening? The answer is that they vary from country to country, even where resources are plentiful.In the United States, the guidelines have been radically revised in the past 2 years. Despite three authoritative bodies offering different recommendations there is reasonable consensus as follows:Age to start testing: Age 21 years (cf, age 25 years in many European countries) and not at the onset of sexual activity.Frequency of testing: Every 3 years (previously annually).Cotesting with HPV DNA: Cotesting is not uniformly recommended prior to age 30 years and it is not indicated unless specific circumstances are present, such as recurrent cytological abnormalities (reflex testing). Even over age 30 years, routine HPV DNA testing is of dubious value.Age to stop testing: Generally age 65 years, provided the woman has had consistently negative screening.Posthysterectomy: Unnecessary if the histology did not reveal dysplasia or cancer.There are at present no separate recommendations for HPV-vaccinated women.It is clear that routine screening of low-risk women is becoming less intensive as evidence accumulates on the natural history of HPV infections. Testing will become individualized for the vaccinated patient and the highrisk, immunosuppressed patient. The call for clinical judgment and personalized care is clear.1The situation is very different in countries with low resources. Because of limited access to screening of any type, it is important that the test is accurate, cost effective, and detects cervical intraepithelial neoplasia of high grades and cancer. Under these circumstances, self-collection of vaginal samples for HPV DNA testing is a realistic option, as proven by a large trial in Mexico comparing the technique with conventional cytology.2 Although the present cost of HPV testing is relatively high, the high sensitivity of the screening carries advantages where the women may only present a few times for screening in their lives.In the trial, women found self-sampling more acceptable than clinic visits, and once cost and positive-result triaging problems can be resolved, HPV DNA testing could be the screening method of choice in developing countries.In the American literature, there are appeals for a less blanket approach to screening and routine investigations and one wonders when the US annual pelvic examination will come under rigorous investigation." @default.
• W2415915087 created "2016-06-24" @default.
• W2415915087 creator A5047083782 @default.
• W2415915087 date "2012-01-01" @default.
• W2415915087 modified "2023-09-23" @default.
• W2415915087 title "Cervical screening routines." @default.
• W2415915087 cites W2029832908 @default.
• W2415915087 cites W2163852430 @default.
• W2415915087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3349925" @default.
• W2415915087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22582128" @default.
• W2415915087 hasPublicationYear "2012" @default.
• W2415915087 type Work @default.
• W2415915087 sameAs 2415915087 @default.
• W2415915087 citedByCount "0" @default.
• W2415915087 crossrefType "journal-article" @default.
• W2415915087 hasAuthorship W2415915087A5047083782 @default.
• W2415915087 hasConcept C121608353 @default.
• W2415915087 hasConcept C126322002 @default.
• W2415915087 hasConcept C2778220009 @default.
• W2415915087 hasConcept C2780647465 @default.
• W2415915087 hasConcept C29456083 @default.
• W2415915087 hasConcept C2994273702 @default.
• W2415915087 hasConcept C40993552 @default.
• W2415915087 hasConcept C512399662 @default.
• W2415915087 hasConcept C54355233 @default.
• W2415915087 hasConcept C65051434 @default.
• W2415915087 hasConcept C71924100 @default.
• W2415915087 hasConcept C86803240 @default.
• W2415915087 hasConceptScore W2415915087C121608353 @default.
• W2415915087 hasConceptScore W2415915087C126322002 @default.
• W2415915087 hasConceptScore W2415915087C2778220009 @default.
• W2415915087 hasConceptScore W2415915087C2780647465 @default.
• W2415915087 hasConceptScore W2415915087C29456083 @default.
• W2415915087 hasConceptScore W2415915087C2994273702 @default.
• W2415915087 hasConceptScore W2415915087C40993552 @default.
• W2415915087 hasConceptScore W2415915087C512399662 @default.
• W2415915087 hasConceptScore W2415915087C54355233 @default.
• W2415915087 hasConceptScore W2415915087C65051434 @default.
• W2415915087 hasConceptScore W2415915087C71924100 @default.
• W2415915087 hasConceptScore W2415915087C86803240 @default.
• W2415915087 hasLocation W24159150871 @default.
• W2415915087 hasOpenAccess W2415915087 @default.
• W2415915087 hasPrimaryLocation W24159150871 @default.
• W2415915087 hasRelatedWork W121462603 @default.
• W2415915087 hasRelatedWork W1902305135 @default.
• W2415915087 hasRelatedWork W1936727996 @default.
• W2415915087 hasRelatedWork W193692636 @default.
• W2415915087 hasRelatedWork W2045403138 @default.
• W2415915087 hasRelatedWork W2071090305 @default.
• W2415915087 hasRelatedWork W2083286973 @default.
• W2415915087 hasRelatedWork W2144316263 @default.
• W2415915087 hasRelatedWork W2266013275 @default.
• W2415915087 hasRelatedWork W2279861052 @default.
• W2415915087 hasRelatedWork W2314653726 @default.
• W2415915087 hasRelatedWork W2402926005 @default.
• W2415915087 hasRelatedWork W2586654841 @default.
• W2415915087 hasRelatedWork W2587233401 @default.
• W2415915087 hasRelatedWork W2737227109 @default.
• W2415915087 hasRelatedWork W2790868370 @default.
• W2415915087 hasRelatedWork W2991443264 @default.
• W2415915087 hasRelatedWork W3095486834 @default.
• W2415915087 hasRelatedWork W3139634748 @default.
• W2415915087 hasRelatedWork W820373847 @default.
• W2415915087 isParatext "false" @default.
• W2415915087 isRetracted "false" @default.
• W2415915087 magId "2415915087" @default.
• W2415915087 workType "article" @default.