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• W2415956307 abstract "Muscular dystrophy is a hereditary musculoskeletal disorder caused by a mutation in the dystrophin gene. Duchenne muscular dystrophy (DMD) is one of the most common, and progresses relatively faster than other muscular dystrophies. It is characterized by progressive myofiber degeneration, muscle weakness and ultimately ambulatory loss. Since it is an X-linked recessive inheritance, DMD is mostly expressed in males and rarely expressed or less severe in females. The most effective measurement tool for DMD is magnetic resonance imaging (MRI), which allows non-invasive examination of longitudinal measurement. It can detect progressive decline of skeletal muscle size by measuring a maximal cross-sectional area of skeletal muscle. Additionally, other techniques in MRI, like T2-weighted imaging, assess muscle damage, including inflammation, by detecting changes in T2 relaxation time. Current MRI techniques even allow quantification of metabolic differences between affected and non-affected muscles in DMD. There is no current cure, but physical therapist can improve their quality of life by maintaining muscle strength and function, especially if treatment (and other forms of medical intervention) begins in the early stages of the disease." @default.
• W2415956307 created "2016-06-24" @default.
• W2415956307 creator A5016122341 @default.
• W2415956307 date "2015-09-18" @default.
• W2415956307 modified "2023-09-25" @default.
• W2415956307 title "Magnetic Resonance Imaging as a Biomarker for Duchenne Muscular Dystrophy" @default.
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• W2415956307 doi "https://doi.org/10.12674/ptk.2015.22.3.098" @default.
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