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- W2416009241 abstract "Thr-Thr-Met-Pro-Leu-Trp, the C-terminal hexapeptide of αsl-casein, inhibited the angiotensin I-converting enzyme (I50 = 16 μM). Z-Pro-Leu-Trp also inhibited the enzyme (I50 = 18 μM). The Pro- Leu-Trp sequence may be important for the inhibitory activity of this hexapeptide. Z-Pro-Val-Trp, which contains Val in place of Leu, inhibited the enzyme more potently (I50 =2.9 μM).The antihypertensive activity of this hexapeptide was also investigated. This peptide, when intravenously administered to anesthetized rats at 31.8 mg/kg, tended to antagonize the rats’ pressor response to angiotensin I." @default.
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- W2416009241 date "1987-09-01" @default.
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- W2416009241 title "Angiotensin I-Converting Enzyme Inhibitory Activity of the C-Terminal Hexapeptide of αs1-Casein" @default.
- W2416009241 doi "https://doi.org/10.1080/00021369.1987.10868415" @default.
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