Matches in SemOpenAlex for { <https://semopenalex.org/work/W2416016827> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2416016827 endingPage "13" @default.
- W2416016827 startingPage "4409" @default.
- W2416016827 abstract "The antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA), developed in this laboratory as a potent analogue of flavone acetic acid (FAA), has a novel antitumour action involving both immune and vascular components. DMXAA induces the synthesis of tumour necrossi factor-alpha (TNF) and it has been hypothesised that this mediates its selective reduction of tumour blood flow and consequent induction of tumour necrosis. Unexpectedly, the drug thalidomide, while reducing the serum TNF response to DMXAA, potentiates its antitumour effect. We have investigated this in the MDAH-MCa-4 mammary carcinoma model, comparing it to previous data with the Colon 38 adenocarcinoma. We have related DMXAA-induced blood flow changes in the MCa-4 tumour to tumour growth delay, serum TNF and extractable TNF from tumour tissue. We have also compared the effect of thalidomide (387 mumol/kg) on DMXAA (80 mumol/kg) with that of a monoclonal anti-TNF antibody (50 micrograms/mouse). We find that tumour blood flow reduction is strongly correlated with tumour growth delay. Coadministration of anti-TNF antibody abolishes serum TNF levels and slightly reduces the antitumour effects of DMXAA. While tumour growth delay is not correlated with serum induced TNF levels, it is related to tumour TNF levels. We conclude that while the data are consistent with TNF being the principal mediator of the action of DMXAA, serum TNF levels do not reflect the antitumour response." @default.
- W2416016827 created "2016-06-24" @default.
- W2416016827 creator A5061684371 @default.
- W2416016827 creator A5063519038 @default.
- W2416016827 creator A5070553149 @default.
- W2416016827 creator A5076724733 @default.
- W2416016827 date "1999-01-19" @default.
- W2416016827 modified "2023-09-26" @default.
- W2416016827 title "Suppression of serum tumour necrosis factor-alpha by thalidomide does not lead to reversal of tumour vascular collapse and anti-tumour activity of 5,6-dimethylxanthenone-4-acetic acid." @default.
- W2416016827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9891501" @default.
- W2416016827 hasPublicationYear "1999" @default.
- W2416016827 type Work @default.
- W2416016827 sameAs 2416016827 @default.
- W2416016827 citedByCount "10" @default.
- W2416016827 crossrefType "journal-article" @default.
- W2416016827 hasAuthorship W2416016827A5061684371 @default.
- W2416016827 hasAuthorship W2416016827A5063519038 @default.
- W2416016827 hasAuthorship W2416016827A5070553149 @default.
- W2416016827 hasAuthorship W2416016827A5076724733 @default.
- W2416016827 hasConcept C126322002 @default.
- W2416016827 hasConcept C159654299 @default.
- W2416016827 hasConcept C17991360 @default.
- W2416016827 hasConcept C203014093 @default.
- W2416016827 hasConcept C2776364478 @default.
- W2416016827 hasConcept C2778690821 @default.
- W2416016827 hasConcept C2779609412 @default.
- W2416016827 hasConcept C503630168 @default.
- W2416016827 hasConcept C542903549 @default.
- W2416016827 hasConcept C71924100 @default.
- W2416016827 hasConcept C98274493 @default.
- W2416016827 hasConceptScore W2416016827C126322002 @default.
- W2416016827 hasConceptScore W2416016827C159654299 @default.
- W2416016827 hasConceptScore W2416016827C17991360 @default.
- W2416016827 hasConceptScore W2416016827C203014093 @default.
- W2416016827 hasConceptScore W2416016827C2776364478 @default.
- W2416016827 hasConceptScore W2416016827C2778690821 @default.
- W2416016827 hasConceptScore W2416016827C2779609412 @default.
- W2416016827 hasConceptScore W2416016827C503630168 @default.
- W2416016827 hasConceptScore W2416016827C542903549 @default.
- W2416016827 hasConceptScore W2416016827C71924100 @default.
- W2416016827 hasConceptScore W2416016827C98274493 @default.
- W2416016827 hasIssue "6A" @default.
- W2416016827 hasLocation W24160168271 @default.
- W2416016827 hasOpenAccess W2416016827 @default.
- W2416016827 hasPrimaryLocation W24160168271 @default.
- W2416016827 hasRelatedWork W1976181892 @default.
- W2416016827 hasRelatedWork W1977918131 @default.
- W2416016827 hasRelatedWork W2017924932 @default.
- W2416016827 hasRelatedWork W2033078812 @default.
- W2416016827 hasRelatedWork W2049714321 @default.
- W2416016827 hasRelatedWork W2054766380 @default.
- W2416016827 hasRelatedWork W2056732812 @default.
- W2416016827 hasRelatedWork W2093278568 @default.
- W2416016827 hasRelatedWork W2111796536 @default.
- W2416016827 hasRelatedWork W2151614054 @default.
- W2416016827 hasVolume "18" @default.
- W2416016827 isParatext "false" @default.
- W2416016827 isRetracted "false" @default.
- W2416016827 magId "2416016827" @default.
- W2416016827 workType "article" @default.